An integrated network pharmacology approach reveals that Darutigenol reduces inflammation and cartilage degradation in a mouse collagen-induced arthritis model by inhibiting the JAK-STAT3 pathway

Wang, Yong; Yan, Hui; Zhao, Liang; He, Xuelai; Bao, Te-Ri-Gen; Sun, Xian-Duo; Yang, Yong-Cheng; Zhu, Shu-Yi; Gao, Xueke; Wang, An-Hua; Jia, Jing‐Ming

doi:10.1016/j.jep.2023.116574

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Darutigenol has been shown to possess anti-RA properties by effectively suppressing joint inflammation and inhibiting cartilage degradation through the IL-6/JAK1,3/STAT3 pathway. Furthermore, it effectively downregulates the expression and activity of MMP2 and MMP9, which are key enzymes involved in cartilage degradation ( 54 ). Genkwanin has the ability to suppress the activation of the NF-κB and JAK/STAT signaling pathways, thereby leading to a reduction in the expression of IL-6, NO, and TNF-α.…”

Section: Chinese Herbal Medicine Remission Of Rheumatoid Arthritismentioning

confidence: 99%

Advantages of Chinese herbal medicine in treating rheumatoid arthritis: a focus on its anti-inflammatory and anti-oxidative effects

Wang,

Kong,

2024

Front. Med.

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Oxidative stress is a condition characterized by an imbalance between the oxidative and antioxidant processes within the human body. Rheumatoid arthritis (RA) is significantly influenced by the presence of oxidative stress, which acts as a pivotal factor in its pathogenesis. Elevated levels of mitochondrial reactive oxygen species (ROS) and inflammation have been found to be closely associated in the plasma of patients with RA. The clinical treatment strategies for this disease are mainly chemical drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), glucocorticoids (GCs) and biological agents, but it is difficult for patients to accept long-term drug treatment and its side effects. In the theory of traditional Chinese medicine (TCM), RA is thought to be caused by the attack of “wind, cold, damp humor,” and herbs with the effect of removing wind and dampness are used to relieve pain. Chinese herbal medicine boasts a rich heritage in effectively attenuating the symptoms of RA, and its global recognition continues to ascend. In particular, RA-relevant anti-inflammatory/anti-oxidative effects of TCM herbs/herbal compounds. The main aim of this review is to make a valuable contribution to the expanding pool of evidence that advocates for the incorporation of Chinese herbal medicine in conventional treatment plans for RA.

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Section: Chinese Herbal Medicine Remission Of Rheumatoid Arthritismentioning

confidence: 99%

Advantages of Chinese herbal medicine in treating rheumatoid arthritis: a focus on its anti-inflammatory and anti-oxidative effects

Wang,

Kong,

2024

Front. Med.

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Water extracts of Tibetan medicine Wuweiganlu attenuates experimental arthritis via inducing macrophage polarization towards the M2 type

Wen

Zhang

Meng

et al. 2024

Journal of Ethnopharmacology

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An integrated network pharmacology approach reveals that Darutigenol reduces inflammation and cartilage degradation in a mouse collagen-induced arthritis model by inhibiting the JAK-STAT3 pathway

Cited by 2 publications

References 33 publications

Advantages of Chinese herbal medicine in treating rheumatoid arthritis: a focus on its anti-inflammatory and anti-oxidative effects

Advantages of Chinese herbal medicine in treating rheumatoid arthritis: a focus on its anti-inflammatory and anti-oxidative effects

Water extracts of Tibetan medicine Wuweiganlu attenuates experimental arthritis via inducing macrophage polarization towards the M2 type

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