An integrated microfluidic cell for detection, manipulation, and sorting of single micron-sized magnetic beads

Jiang, Zhe; Llandro, J.; Mitrelias, T.; Bland, J. A. C.

doi:10.1063/1.2176238

Cited by 58 publications

(37 citation statements)

References 18 publications

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“…In this respect, magnetoresistive sensors, especially those relying on the GMR effect represent an efficient solution for the use in fluidic biodetection platforms due to their high sensitivity 195 . Planar 88,196,197 as well as rolled-up 85 magnetic sensors are already incorporated in microfluidic channels enabling detection of magnetic particles. The fabrication of these magnetic sensors requires intensive lithography processing and is therefore expensive and time consuming 187,190 .…”

Section: Gmr Sensors In Circumferential Geometrymentioning

confidence: 99%

Stretchable Magnetoelectronics

et al. 2011

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Abstract:In this work, stretchable magnetic sensorics is successfully established by combining metallic thin films revealing a giant magnetoresistance effect with elastomeric materials. Stretchability of the magnetic nanomembranes is achieved by specific morphologic features (e.g. wrinkles), which accommodate the applied tensile deformation while maintaining the electrical and magnetic integrity of the sensor device. The entire development, from the demonstration of the world-wide first elastically stretchable magnetic sensor to the realization of a technology platform for robust, ready-touse elastic magnetoelectronics with fully strain invariant properties, is described. The prepared soft giant magnetoresistive devices exhibit the same sensing performance as on conventional rigid supports, but can be stretched uniaxially or biaxially reaching strains of up to 270% and endure over 1,000 stretching cycles without fatigue. The comprehensive magnetoelectrical characterization upon tensile deformation is correlated with in-depth structural investigations of the sensor morphology transitions during stretching.With their unique mechanical properties, the elastic magnetoresistive sensor elements readily conform to ubiquitous objects of arbitrary shapes including the human skin. This feature leads electronic skin systems beyond imitating the characteristics of its natural archetype and extends their cognition to static and dynamic magnetic fields that by no means can be perceived by human beings naturally.Various application fields of stretchable magnetoelectronics are proposed and realized throughout this work. The developed sensor platform can equip soft electronic systems with navigation, orientation, motion tracking and touchless control capabilities. A variety of novel technologies, like smart textiles, soft robotics and actuators, active medical implants and soft consumer electronics will benefit from these new magnetic functionalities. Michael Melzer: Stretchable MagnetoelectronicsOutline 4

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Section: Gmr Sensors In Circumferential Geometrymentioning

confidence: 99%

Stretchable Magnetoelectronics

et al. 2011

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“…19 While useful, these investigations do not provide a quantitative particle-tracking model that is applicable regardless of configuration and geometry. Previous simulations of magnetic particle transport in microfluidic contexts 20 have also not focused on individual particle trajectories or detailed parametric analyses.…”

mentioning

confidence: 99%

Single magnetic particle dynamics in a microchannel

Sinha

Ganguly

et al. 2007

Physics of Fluids

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Functionalized magnetic particles are used in micrototal analysis systems since they act as magnetically steered mobile substrates in microfluidic channels, and can be collected for bioanalytical processing. Here, we examine the motion of magnetic microbeads in a microfluidic flow under the influence of a nonuniform external magnetic field and characterize their collection in terms of the magnetic field strength, particle size, magnetic susceptibility, host fluid velocity and viscosity, and the characteristic length scale. We show that the collection efficiency of a magnetic collector depends upon two dimensionless numbers that compare the magnetic and particle drag forces.

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“…The susceptibility of paramagnetic materials can be very small compared to ferromagnetic materials. 35 It was shown that magnetic moment of individual ferromagnetic bead is approximately ten times more than the same size superparamagnetic bead; 36,37 this fact resulted in longer bead chains and faster response to magnetic field in our experiments.…”

mentioning

confidence: 71%

“…The excessive dye was rinsed off with water to complete the standard simple staining procedure. 37,39 To perform magnetic dipole-dipole interaction, ferromagnetic beads (8 μm) suspended in PBS buffer added to stained bacteria and the platform, including permanent magnets, were placed on the two sides of the droplet on the glass slide, as in Figure 7. The anti-E. coli magnetic beads were attracted to ferromagnetic beads as a result of magnetic dipole-dipole interaction forming an accumulation as:…”

Section: Magnetic Accumulation On E Coli Samplesmentioning

confidence: 99%

Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing

Mzava

Taş

İçöz

2016

IJN

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We report a time and cost efficient signal amplification method for biosensors employing magnetic particles. In this method, magnetic particles in an applied external magnetic field form magnetic dipoles, interact with each other, and accumulate along the magnetic field lines. This magnetic interaction does not need any biomolecular coating for binding and can be controlled with the strength of the applied magnetic field. The accumulation can be used to amplify the corresponding pixel area that is obtained from an image of a single magnetic particle. An application of the method to the Escherichia coli 0157:H7 bacteria samples is demonstrated in order to show the potential of the approach. A minimum of threefold to a maximum of 60-fold amplification is reached from a single bacteria cell under a magnetic field of 20 mT.

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An integrated microfluidic cell for detection, manipulation, and sorting of single micron-sized magnetic beads

Cited by 58 publications

References 18 publications

Stretchable Magnetoelectronics

Stretchable Magnetoelectronics

Single magnetic particle dynamics in a microchannel

Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing

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