An integrated magneto-opto-fluidic biosensor for rapid on-chip assay of respiratory viruses of livestock

Zhang, Qinming; Rawal, Gaurav; Qian, Jiaru; Ibrahim, Hussam; Zhang, Jianqiang; Dong, Liang; Lu, Meng

doi:10.1039/d2lc00406b

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…For virus detection by PCR, which typically involves samples extraction, nucleic acid purification, and detection, Zhang Q. et al (2022) developed an immunomagnetic virus enrichment method using MNPs and a biosensor system-on-chip (IMOF) based on photonic crystals (PC) ( Figure 4 ). This approach employed antibody-functionalized MNPs to specifically target and concentrate the virus while improving the output efficiency of the PC sensor, enabling automated detection.…”

Section: The Impact Of Magnetic Nanoparticles On Biological Detectionmentioning

confidence: 99%

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Advancements in magnetic nanoparticle-based biosensors for point-of-care testing

Wang,

Jin,

Hang-Mei Leung

et al. 2024

Front. Bioeng. Biotechnol.

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The significance of point-of-care testing (POCT) in early clinical diagnosis and personalized patient care is increasingly recognized as a crucial tool in reducing disease outbreaks and improving patient survival rates. Within the realm of POCT, biosensors utilizing magnetic nanoparticles (MNPs) have emerged as a subject of substantial interest. This review aims to provide a comprehensive evaluation of the current landscape of POCT, emphasizing its growing significance within clinical practice. Subsequently, the current status of the combination of MNPs in the Biological detection has been presented. Furthermore, it delves into the specific domain of MNP-based biosensors, assessing their potential impact on POCT. By combining existing research and spotlighting pivotal discoveries, this review enhances our comprehension of the advancements and promising prospects offered by MNP-based biosensors in the context of POCT. It seeks to facilitate informed decision-making among healthcare professionals and researchers while also promoting further exploration in this promising field of study.

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Section: The Impact Of Magnetic Nanoparticles On Biological Detectionmentioning

confidence: 99%

“…(C) Diagram illustrating the label-free analysis via resonant reflection spectra measured from PC sensors, with MNPs enhancing the shift of the resonant wavelength due to the absorption of target MNP–virus conjugates. Reprinted with permission from Zhang Q. et al (2022) .…”

Section: The Impact Of Magnetic Nanoparticles On Biological Detectionmentioning

confidence: 99%

Advancements in magnetic nanoparticle-based biosensors for point-of-care testing

Wang,

Jin,

Hang-Mei Leung

et al. 2024

Front. Bioeng. Biotechnol.

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“…The purification of samples is also effective [103,194]. The purification often requires large equipment such as centrifuges, but there have been vigorous attempts to integrate a purification unit onto the biosensor chip [195][196][197]. In contrast to passive methods to prevent nonspecific adsorption from occurring as described above, methods to actively remove nonspecifically adsorbed molecules have also been proposed.…”

Section: Attempt To Rationally Extract Signals From Samples With Comp...mentioning

confidence: 99%

Challenges for Field-Effect-Transistor-Based Graphene Biosensors

Ono,

Okuda,

Ushiba

et al. 2024

Materials

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Owing to its outstanding physical properties, graphene has attracted attention as a promising biosensor material. Field-effect-transistor (FET)-based biosensors are particularly promising because of their high sensitivity that is achieved through the high carrier mobility of graphene. However, graphene-FET biosensors have not yet reached widespread practical applications owing to several problems. In this review, the authors focus on graphene-FET biosensors and discuss their advantages, the challenges to their development, and the solutions to the challenges. The problem of Debye screening, in which the surface charges of the detection target are shielded and undetectable, can be solved by using small-molecule receptors and their deformations and by using enzyme reaction products. To address the complexity of sample components and the detection mechanisms of graphene-FET biosensors, the authors outline measures against nonspecific adsorption and the remaining problems related to the detection mechanism itself. The authors also introduce a solution with which the molecular species that can reach the sensor surfaces are limited. Finally, the authors present multifaceted approaches to the sensor surfaces that provide much information to corroborate the results of electrical measurements. The measures and solutions introduced bring us closer to the practical realization of stable biosensors utilizing the superior characteristics of graphene.

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“…The design flexibility and development of novel materials have advanced the 3D printing methods used to manufacture respiratory biosensors for monitoring breathing patterns, respiratory rate, virus detection, and lung function, as illustrated in Figure 12. Wearable biosensors have the capability to collect valuable data and provide crucial insights for the timely detection of respiratory illnesses and the optimization of respiratory remedies [152,[208][209][210][211][212][213][214]. Martins et al demonstrated the fabrication of an immunosensor with fused deposition modeling using a conductive filament of carbon black and polylactic acid (PLA).…”

Section: Respiratory Biosensorsmentioning

confidence: 99%

The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects

Parupelli,

Desai

2023

Bioengineering

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Notably, 3D-printed flexible and wearable biosensors have immense potential to interact with the human body noninvasively for the real-time and continuous health monitoring of physiological parameters. This paper comprehensively reviews the progress in 3D-printed wearable biosensors. The review also explores the incorporation of nanocomposites in 3D printing for biosensors. A detailed analysis of various 3D printing processes for fabricating wearable biosensors is reported. Besides this, recent advances in various 3D-printed wearable biosensors platforms such as sweat sensors, glucose sensors, electrocardiography sensors, electroencephalography sensors, tactile sensors, wearable oximeters, tattoo sensors, and respiratory sensors are discussed. Furthermore, the challenges and prospects associated with 3D-printed wearable biosensors are presented. This review is an invaluable resource for engineers, researchers, and healthcare clinicians, providing insights into the advancements and capabilities of 3D printing in the wearable biosensor domain.

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An integrated magneto-opto-fluidic biosensor for rapid on-chip assay of respiratory viruses of livestock

Abstract: This work demonstrated an on-chip virus analysis technology that can characterize multiple viruses in clinical samples with automated sample processing and detection.

Cited by 5 publications

References 36 publications

Advancements in magnetic nanoparticle-based biosensors for point-of-care testing

Advancements in magnetic nanoparticle-based biosensors for point-of-care testing

Challenges for Field-Effect-Transistor-Based Graphene Biosensors

The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects

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