An Integrated Framework for Human Neuroimaging Studies of Addiction from a Preclinical Perspective

Ersche, Karen D.; Robbins, Trevor W.

doi:10.1002/9781119998938.ch2

Cited by 3 publications

(1 citation statement)

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“…Reportedly, 5-HTergic neural systems are involved in the drugdependence mechanism (6,7). The nucleus accumbens (NAcc) plays an important role in the psychological effects and reward process of MAP (8). Stimulationelicited neuronal activities in NAcc were inhibited by several neurotransmitters such as dopamine, 5-HT, and adenosine (9,10).…”

Section: Introductionmentioning

confidence: 99%

Serotonergic Modulation of Neuronal Activity in the Nucleus Accumbens Following Repeated Methamphetamine Administration in Rats

et al. 2013

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Abstract. Electrophysiological studies were performed to determine whether serotonergic modulation in the nucleus accumbens (NAcc) was affected after repeated methamphetamine (MAP) administration. NAcc slices (400 mm) from Wistar rats administered MAP (5 mg/kg) or saline once daily for 5 days were prepared 1, 5, or 10 days after the final injection. Population spikes (PS) induced by local stimulation of NAcc were recorded. PS inhibition by serotonin was significantly attenuated in the MAP group at 5 days but did not differ at 1 or 10 days. We next analyzed the effects of serotonin receptor subtype (5-HT 1A,2,3,4,6,7 )-selective agonists of PS. Differences between saline and MAP groups in 5-HT 1A,2,3,4,6 receptor agonist-induced changes of PS were small or not significant. Interestingly, 5-HT 7 receptor agonists significantly enhanced PS in the MAP group. Changes in the secondary messenger system related to 5-HT 7 receptors were also investigated. Adenylate cyclase activator-induced PS enhancements were significantly larger in the MAP group. However, dibutyryl-cAMP-induced PS enhancement was not significantly different. In conclusion, 5-HT-induced inhibition of PS in NAcc was attenuated 5 days after repeated MAP treatment: the change in the effect of 5-HT was probably due to enhancement of the excitatory modulation via the 5-HT 7 receptor with adenylate cyclase signal transduction systems. [Supplementary Figure: available only at http://dx

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