An Integrated Control and Readout Circuit for Implantable Multi-Target Electrochemical Biosensing

et al. 2015

IEEE Sensors J.

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Abstract-This paper represents the extended version of the conference paper "Developing highly-integrated subcutaneous biochips for remote monitoring of human metabolism" presented at the IEEE Sensors Conference 2012, and presents data on assembly, packaging and short term in vitro and in vivo biocompatibility evaluation of a fully implantable biosensor array. The device was realized integrating three building blocks: 1) a multielectrode platform; 2) an inductive coil; and 3) an integrated circuit. The entire system measures 2.2 mm × 2.2 mm × 15 mm. Corrosion of electronic components and leaking of potentially hazardous substances in the body is prevented with a conformal coating of Parylene C, while an outer package of medical grade silicone was employed to create a soft shell suitable for implantation. Biocompatibility experiments did not show in vitro cytotoxicity in the considered period of 7 days, while comparison between 7 and 30 days in vivo implantations showed significant reduction of the inflammatory response in time, suggesting normal host recovery.

Section: Discussionmentioning

confidence: 99%

A Subcutaneous Biochip for Remote Monitoring of Human Metabolism: Packaging and Biocompatibility Assessment

Cavallini

Jost²,

et al. 2015

IEEE Sensors J.

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“…More information about the design of the readout and control IC can be found in [18]. We have also developed another type of CA and CV readout circuit based on current to frequency conversion [19]. A sample timing schedule for the measurements is shown in Fig.…”

Section: B Integrated Circuits and Communication Protocol Designmentioning

confidence: 99%

Full Fabrication and Packaging of an Implantable Multi-Panel Device for Monitoring of Metabolites in Small Animals

Baj-Rossi

Kilinc

IEEE Trans. Biomed. Circuits Syst.

et al. 2014

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Abstract-In this work, we show the realization of a fully-implantable device for monitoring free-moving small animals. The device integrates a microfabricated sensing platform, a coil for power and data transmission and two custom designed integrated circuits. The device is intended to be implanted in mice, free to move in a cage, to monitor the concentration of metabolites. We show the system level design of each block of the device, and we present the fabrication of the passive sensing platform and its employment for the electrochemical detection of endogenous and exogenous metabolites. Moreover, we describe the assembly of the device to test the biocompatibility of the materials used for the microfabrication. To ensure biocompatibility, an epoxy enhanced polyurethane membrane was used to cover the device. We proved through an in-vitro characterization that the membrane was capable to retain enzyme activity up to 35 days. After 30 days of implant in mice, in-vivo experiments proved that the membrane promotes the integration of the sensor with the surrounding tissue, as demonstrated by the low inflammation level at the implant site.

“…6. The generated waveform sweeps the voltage between 200 mV and 1.6 V [13]. The generated waveform goes through a voltage buffer which acts as a low-pass filter.…”

Section: B Control and Readout Electronicsmentioning

confidence: 99%

An implantable bio-micro-system for drug monitoring

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

Kilinc²,

Baj-Rossi

et al. 2013

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Abstract-Multi-target and continuous monitoring by wireless implantable devices is of increasing interest for personalized therapy. In this work an implantable system is presented which is capable of measuring different drugs with Cyclic Voltammetry (CV) method. The wireless microsystem consists of four modules, namely (i) The inductive coil; (ii) Power management IC; (iii) Readout and control IC; (iv) Biosensor array. The power management IC provides 1.8 V with as high as 2 mW power for the readout IC. The configurable readout IC is able to control the biosensor array and measure the sensor current in CV method. CV experiments performed with this microsystem well agree with a commercial equipment for two well known anti-cancer drugs, Etoposide and Mitoxantrone, detection.