An Integrated Bidirectional Multi-Channel Opto-Electro Arbitrary Waveform Stimulator for Treating Motor Neurone Disease

Abstract

This paper presents a prototype integrated bidirectional stimulator ASIC capable of mixed opto-electro stimulation and electrophysiological signal recording. The development is part of the research into a fully implantable device for treating motor neurone disease using optogenetics and stem cell technology. The ASIC consists of 4 stimulator units, each featuring 16-channel optical and electrical stimulation using arbitrary current waveforms with an amplitude up to 16 mA and a frequency from 1.5 Hz to 50 kHz, and a recording front-end with a programmable bandwidth of 1 Hz to 4 kHz, and a programmable amplifier gain up to 74 dB. The ASIC was implemented in a 0.18-µm CMOS technology. Simulated performance in stimulation and recording is presented.

Towards a Fully Implantable Closed-Loop Opto-Electro Stimulation Interface for Motor Neuron Disease Treatment

“…The details of ASIC used in this study for generating stimulation pulses were presented in [8]. The bidirectional stimulator ASIC is capable of mixed opto-electro stimulation and electrophysiological signal recording.…”

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

“…This paper presents a fully implantable multi-channel stimulating and recording implant for closed-loop opto-electro stimulation in rodents (rats). Previous papers only briefly introduced the design considerations of the ASIC [23] and the overall system [24]. This paper presents an improved ASIC with an integrated analog to digital converter (ADC), having lower noise and a broad bandwidth.…”