An integrated approach to understand biological stress system dysregulation across depressive and anxiety disorders

Vinkers, Christiaan H.; Kuzminskaite, Erika; Lamers, Femke; Giltay, Erik J.; Penninx, Brenda W. J. H.

doi:10.1016/j.jad.2021.01.051

Cited by 43 publications

(27 citation statements)

References 51 publications

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“…Acute and chronic stress, through mainly the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, play a crucial role in immune system dysregulation and psychiatric disorders, as the last few decades of psychiatric research have unveiled ( Vinkers et al., 2021 ; Belvederi Murri et al., 2014 ; Turner-Cobb, 2005 ; Tsigos and Chrousos, 1994 ). Chronically high levels of cortisol, the “stress hormone”, can induce the production of inflammatory cytokines, leading to the suppression of homeostatic cellular and humoral functions.…”

Section: Introductionmentioning

confidence: 99%

The role of yoga in inflammatory markers

Estevao

2022

Brain, Behavior, & Immunity - Health

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Section: Introductionmentioning

confidence: 99%

The role of yoga in inflammatory markers

Estevao

2022

Brain, Behavior, & Immunity - Health

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“…One hypothesis for metabolic changes in anxiety and depression is the pronounced stimulation and putative hyperactivation of the endogenous stress system by life events [ 13 , 46 ]. In MDD, this has also been related to higher age acceleration determined by epigenetic age markers [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

et al. 2022

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Background Panic disorder (PD) is characterized by recurrent panic attacks and higher affection of women as compared to men. The lifetime prevalence of PD is about 2–3% in the general population leading to tremendous distress and disability. Etiologically, genetic and environmental factors, such as stress, contribute to the onset and relapse of PD. In the present study, we investigated epigenome-wide DNA methylation (DNAm) in respond to a cumulative, stress-weighted life events score (wLE) in patients with PD and its boundary to major depressive disorder (MDD), frequently co-occurring with symptoms of PD. Methods DNAm was assessed by the Illumina HumanMethylation450 BeadChip. In a meta-analytic approach, epigenome-wide DNAm changes in association with wLE were first analyzed in two PD cohorts (with a total sample size of 183 PD patients and 85 healthy controls) and lastly in 102 patients with MDD to identify possible overlapping and opposing effects of wLE on DNAm. Additionally, analysis of differentially methylated regions (DMRs) was conducted to identify regional clusters of association. Results Two CpG-sites presented with p-values below 1 × 10−05 in PD: cg09738429 (p = 6.40 × 10−06, located in an intergenic shore region in next proximity of PYROXD1) and cg03341655 (p = 8.14 × 10−06, located in the exonic region of GFOD2). The association of DNAm at cg03341655 and wLE could be replicated in the independent MDD case sample indicating a diagnosis independent effect. Genes mapping to the top hits were significantly upregulated in brain and top hits have been implicated in the metabolic system. Additionally, two significant DMRs were identified for PD only on chromosome 10 and 18, including CpG-sites which have been reported to be associated with anxiety and other psychiatric phenotypes. Conclusion This first DNAm analysis in PD reveals first evidence of small but significant DNAm changes in PD in association with cumulative stress-weighted life events. Most of the top associated CpG-sites are located in genes implicated in metabolic processes supporting the hypothesis that environmental stress contributes to health damaging changes by affecting a broad spectrum of systems in the body.

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“…51 Anxiety and depressive disorders are associated with increased inflammatory activity, HPA-axis hyperactivity, and an increased tone of the autonomic nervous system. 52 Knowledge about the main roles of bioelements in anxiety disorders increased in the latest years. 53 In more detail, deficiency of some elements can lead to an excessive release of glutamate and to excessive activation of the HPA axis.…”

Section: The Burden Of Mental Health Disorders In General Populationmentioning

confidence: 99%

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

Businaro

2022

F1000Res

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Diet and nutrition play a fundamental role not only in human body composition and in physiology, but have also relevant effects on mood, mental well-being and cognitive performance. In particular, the preservation of mental well-being through a healthy lifestyle, including a well-balanced diet and, in case, through the intake of specific food supplements, is of particular relevance in the perspective of global human ageing, as the brain is affected significantly by a persistent presence of stress factors. Due to the increasing burden of mental and neurological disorders and to the universality of food as a modifiable risk factor, even limited improvements in nutritional habits may translate to a considerable rise of well-being and mental health in the global population. Moreover, the use of targeted, well-balanced food supplements aiming to support the mental health and well-being will probably represent a relevant tool in future decades, together with an increased awareness of the importance of nutrition, also considering the COVID-19 pandemic and the related stressful events and limitations we are still experiencing at global level. The aim of this review is to summarize the experimental and clinical data reported in the literature concerning the beneficial effects of a subset of micro- and macronutrients contained both in food and in supplements, namely magnesium, folic acid, docosahexaenoic acid, eicosapentaenoic acid, and alpha-tocopherol, on a series of disorders, including stress, anxiety, low sleep quality, and low cognitive performance.

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An integrated approach to understand biological stress system dysregulation across depressive and anxiety disorders

Cited by 43 publications

References 51 publications

The role of yoga in inflammatory markers

The role of yoga in inflammatory markers

Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

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