An Integrated Approach to Methicillin-Resistant<i>Staphylococcus aureus</i>Control in a Rural, Regional-Referral Healthcare Setting

Bowler, William A.; Bresnahan, Jeanine; Bradfish, Ann; Fernandez, Christine

doi:10.1086/650445

Cited by 30 publications

(34 citation statements)

References 32 publications

(32 reference statements)

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“…Although decreases in antibiotic susceptibility were transient, this nonetheless raises concerns that tea tree oil hinders the effectiveness of conventional antibiotics by either reducing susceptibility or influencing the development of resistance. This is particularly important if tea tree oil is to become more widely used in hospital environments or in long-term care facilities, such as for the decolonization of MRSA carriers (3,11,30). The purpose of this study therefore was to examine whether tea tree oil or its major component, terpinen-4-ol (T4ol), influ-1,8-cineole (3.6%).…”

mentioning

confidence: 99%

Effects of Melaleuca alternifolia (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility

Hammer

Carson

Riley

2012

Antimicrob Agents Chemother

140

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This study examined the effect of subinhibitory Melaleuca alternifolia (tea tree) essential oil on the development of antibiotic resistance in Staphylococcus aureus and Escherichia coli. Frequencies of single-step antibiotic-resistant mutants were determined by inoculating bacteria cultured with or without subinhibitory tea tree oil onto agar containing 2 to 8 times the MIC of each antibiotic and with or without tea tree oil. Whereas most differences in resistance frequencies were relatively minor, the combination of kanamycin and tea tree oil yielded approximately 10-fold fewer resistant E. coli mutants than kanamycin alone. The development of multistep antibiotic resistance in the presence of tea tree oil or terpinen-4-ol was examined by culturing S. aureus and E. coli isolates daily with antibiotic alone, antibiotic with tea tree oil, and antibiotic with terpinen-4-ol for 6 days. Median MICs for each antibiotic alone increased 4-to 16-fold by day 6. Subinhibitory tea tree oil or terpinen-4-ol did not greatly alter results, with day 6 median MICs being either the same as or one concentration different from those for antibiotic alone. For tea tree oil and terpinen-4-ol alone, day 6 median MICs had increased 4-fold for S. aureus (n ‫؍‬ 18) and 2-fold for E. coli (n ‫؍‬ 18) from baseline values. Lastly, few significant changes in antimicrobial susceptibility were seen for S. aureus and S. epidermidis isolates that had been serially subcultured 14 to 22 times with subinhibitory terpinen-4-ol. Overall, these data indicate that tea tree oil and terpinen-4-ol have little impact on the development of antimicrobial resistance and susceptibility.

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mentioning

confidence: 99%

Effects of Melaleuca alternifolia (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility

Hammer

Carson

Riley

2012

Antimicrob Agents Chemother

140

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“…In a rural setting comprised of 1 hospital, 5 affiliated NHs, and 1 ambulatory center, active surveillance resulted in a dramatic decrease in MRSA colonization in NH residents and MRSA infections in hospital patients. 41 Although these results may not translate as well to highly populated areas with complex health care networks, they serve as proof that facilities should be familiar with guidelines and evidence, and monitor rates of MRSA and VRE, and any recent outbreaks.…”

Section: Infection Prevention Programs In Nursing Homes: Functions Cmentioning

confidence: 99%

Infection Control in Alternative Health Care Settings

Flanagan

Cassone

Montoya

et al. 2016

Infectious Disease Clinics of North America

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“…A number of nonexperimental studies examining the combined impact of topical and systemic therapy on MRSA carriage have been published [71][72][73][74]. Three of these studies were initiated in response to an outbreak and are susceptible to a number of methodological biases [75].…”

Section: Prevention Of Infection In Residents With Known Mrsa Colonizmentioning

confidence: 99%

Impact and Management of MRSA in the Long-Term Care Setting

Crnich

2013

Curr Transl Geriatr Exp Gerontol Rep

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Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality in healthcare facilities. Residents of nursing homes are commonly colonized with MRSA and acquisition within these facilities is common. While treatment of MRSA infection in the NH is more costly than treatment of infections caused by methicillin-susceptible strains, the frequency of serious infections and attributable mortality remains uncommon. Consequently, controlling the spread of MRSA in NHs is primarily a population health concern and interventions to control intrafacility transmissions should be balanced with a concern for resident quality-of-life.

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An Integrated Approach to Methicillin-ResistantStaphylococcus aureusControl in a Rural, Regional-Referral Healthcare Setting

Abstract: Use of active surveillance cultures and decolonization therapy was effective in decreasing the prevalence of asymptomatic carriage, the incidence of nosocomial infection, and the overall prevalence of MRSA in our rural healthcare setting.

Cited by 30 publications

References 32 publications

Effects of Melaleuca alternifolia (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility

Effects of Melaleuca alternifolia (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility

Infection Control in Alternative Health Care Settings

Impact and Management of MRSA in the Long-Term Care Setting

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