An integrated approach to discriminate the quality markers of Traditional Chinese medicine preparation based on multi-dimensional characteristic network: Shenqi Jiangtang Granule as a case

Zhang, Hui; Chen, Ruoyu; Xu, Cong; Zhang, Guimin; Guan, Yongxia; Feng, Qun; Yao, Jingchun

doi:10.1016/j.jep.2021.114277

Cited by 11 publications

(2 citation statements)

References 23 publications

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“…AR is widely recognized important factor in the process of the occurrence and development of DN [ 9 – 11 ]. To date, a wide range of synthetic and natural AR inhibitors have been developed.…”

Section: Introductionmentioning

confidence: 99%

Rapid identification of chemical components in Xuelian granule by UHPLC-Q-orbitrap-HRMS based on enzyme activity in vitro

Taximaimaiti,

Abdulla,

Xin

et al. 2023

BMC Complement Med Ther

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Background Xuelian granule (XL), a traditional Chinese medicine (TCM) formula, has been used for the treatment of diabetic nephropathy for a long time as a hospital preparation. Because the active ingredients in the XL that can help to treat diabetic nephropathy are still unclear, which limits the interpretation for its pharmacological mechanism, further development and subsequent study on the material basis of its efficacy. Methods In this study, a screening method based on inhibition activity against aldose reductase (AR) was employed for activity-directed chemical analysis of XL using ultra-high performance liquid chromatography combined with quadrupole-orbitrap high resolution mass spectrometry (UHPLC-Q-orbitrap-HRMS) technique. Results A total of 178 compounds, including 46 terpenes, 47 organic acids, 25 flavonoids, 29 phenylethanoid glycosides, and 31 other types, were tentatively identified from XL which might responsible for its AR inhibition activity. Conclusion This is the first study for a systematic, rapid, and accurate qualitative analysis of XL. This research provides a scientific and experimental basis for further researches on pharmacodynamics material basis and quality control of XL.

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Section: Introductionmentioning

confidence: 99%

Rapid identification of chemical components in Xuelian granule by UHPLC-Q-orbitrap-HRMS based on enzyme activity in vitro

Taximaimaiti,

Abdulla,

Xin

et al. 2023

BMC Complement Med Ther

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“…Traditional Chinese patent medicines are a kind of traditional Chinese medicine preparation that has been developed by doctors after many years of clinical research and has achieved certain curative effects as an auxiliary medicine combined with conventional Western medicine therapy to treat DN. These medicines include Huangkui capsules [3] , bailing capsules, Niaoduqing granules, [4] naoxintong capsules, [5] qishao capsules, [6] Tangweikang capsules, [7] Jinshuibao capsules, [8] Shenqi Jiangtang granules, [9] Sanhuang Yishen capsules, [10] and so on [3] . The treatment guidelines [11] also emphasize the important role of Huangkui capsules and Keluoxin capsules in the treatment of the disease.…”

Section: Introductionmentioning

confidence: 99%

Comparison of efficacy and safety of traditional Chinese patent medicines for diabetic nephropathy

Liu

Jiang

et al. 2022

Medicine

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Background: Diabetic nephropathy (DN) is one of the most serious complications of diabetes. It has become a global public health problem among humans. DN is the leading cause of end-stage renal disease. At present, there is no specific medicine or modern medicinal therapy. In recent years, studies have shown that traditional Chinese patent medicines have been effective in treating DN, with few side effects. There is no systematic review on the treatment of DN with Chinese patent medicines. The current systematic review aims to evaluate the efficacy and safety of Chinese patent medicines for the treatment of DN.Methods: We will develop a search strategy to search major Chinese and English databases from inception to February 25, 2022 for randomized controlled trials examining the use of traditional Chinese patent medicine for the treatment of DN. The search will be conducted in accordance with the participants, interventions, comparisons, outcomes (PICOS) framework. Two researchers will use EndnoteX9 software to extract data and independently evaluate the quality of the included trials. Finally, the Bayesian network meta-analysis will be carried out by using software such as ReviewManager, Stata16.0, and WinBUGS1.4.3.Results: The primary outcomes will be urine albumin excretion rate, urea nitrogen, serum creatinine, total effective rate, and adverse events, and the secondary outcomes will be body mass index, fasting blood glucose, and 2-hPG during 75-g OGTT. These outcomes will be examined to provide a reliable basis for the treatment of DN with different traditional Chinese patent medicines.Conclusion: This review will compare the efficacy and safety of different traditional Chinese patent medicines for treating DN. The results of the study will provide a basis for the selection of adjuvant treatment options for DN.

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Network Pharmacology to Clarify the Effective Substances and Their Action Mechanisms of Traditional Chinese Medicines

Du,

Liang,

Chang

2024

Quality Control of Chinese Medicines

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An integrated approach to discriminate the quality markers of Traditional Chinese medicine preparation based on multi-dimensional characteristic network: Shenqi Jiangtang Granule as a case

Cited by 11 publications

References 23 publications

Rapid identification of chemical components in Xuelian granule by UHPLC-Q-orbitrap-HRMS based on enzyme activity in vitro

Rapid identification of chemical components in Xuelian granule by UHPLC-Q-orbitrap-HRMS based on enzyme activity in vitro

Comparison of efficacy and safety of traditional Chinese patent medicines for diabetic nephropathy

Network Pharmacology to Clarify the Effective Substances and Their Action Mechanisms of Traditional Chinese Medicines

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