An integrated approach for identifying the efficacy and potential mechanisms of TCM against atherosclerosis—Wu-Zhu-Yu decoction as a case study

Li, Caihong; Chi, Chenglin; Li, Wenjing; Li, Zongchao; Wang, Xinlin; Wang, Minjun; Zhang, Leiming; Lü, Jing; Liu, Rongxia

doi:10.1016/j.jep.2022.115436

Cited by 6 publications

(1 citation statement)

References 38 publications

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“…The adverse effects and high costs of synthetic drugs used in AS treatment have spurred growing interest in Chinese medicine. TCM, cherished as a national treasure, features a mature theoretical system and has proven effective in preventing and treating cardiovascular diseases (Li et al, 2023; Li, Chi, et al, 2022; Liu, Li, et al, 2021). Chinese medicine compounding exemplifies the therapeutic concept of TCM evidence‐based treatment.…”

Section: Introductionmentioning

confidence: 99%

Modulation of atherosclerosis‐related signaling pathways by Chinese herbal extracts: Recent evidence and perspectives

Liu,

Guo,

Zhang

2024

Phytotherapy Research

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Atherosclerotic cardiovascular disease remains a preeminent cause of morbidity and mortality globally. The onset of atherosclerosis underpins the emergence of ischemic cardiovascular diseases, including coronary heart disease (CHD). Its pathogenesis entails multiple factors such as inflammation, oxidative stress, apoptosis, vascular endothelial damage, foam cell formation, and platelet activation. Furthermore, it triggers the activation of diverse signaling pathways including Phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt), NF‐E2‐related factor 2/antioxidant response element (Nrf2/ARE), the Notch signaling pathway, peroxisome proliferator‐activated receptor (PPAR), nucleotide oligo‐structural domain‐like receptor thermoprotein structural domain‐associated protein 3 (NLRP3), silencing information regulator 2‐associated enzyme 1 (Sirt1), nuclear transcription factor‐κB (NF‐κB), Circular RNA (Circ RNA), MicroRNA (mi RNA), Transforming growth factor‐β (TGF‐β), and Janus kinase‐signal transducer and activator of transcription (JAK/STAT). Over recent decades, therapeutic approaches for atherosclerosis have been dominated by the utilization of high‐intensity statins to reduce lipid levels, despite significant adverse effects. Consequently, there is a growing interest in the development of safer and more efficacious drugs and therapeutic modalities. Traditional Chinese medicine (TCM) offers a vital strategy for the prevention and treatment of cardiovascular diseases. Numerous studies have detailed the mechanisms through which TCM active ingredients modulate signaling molecules and influence the atherosclerotic process. This article reviews the signaling pathways implicated in the pathogenesis of atherosclerosis and the advancements in research on TCM extracts for prevention and treatment, drawing on original articles from various databases including Google Scholar, Medline, CNKI, Scopus, and Pubmed. The objective is to furnish a reference for the clinical management of cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%