Abstract:DNA is a valid drug target for development of target-based therapeutics against cancer. Screening DNA-targeted anticancer drugs is a key process for the research and development of new anticancer drugs. The traditional anticancer drug screening methods, including animal experiments and cell-based screening assays, have unavoidable drawbacks. In this contribution, the new instrument-based screening assay for DNA-targeted anticancer drugs in vitro using resonance light scattering (RLS) technique was proposed. Th… Show more
“…[20][21][22][23][24][25][26][27][28][29] In our laboratory, we have successfully introduced it into the screening of anticancer drugs. [30][31][32][33] In this work, a novel resonance light scattering amplification system was developed to detect trace amounts of BD in surface water. In the presence of CTMAB, small concentration changes of BD would induce an obvious increase of RLS intensity.…”
“…[20][21][22][23][24][25][26][27][28][29] In our laboratory, we have successfully introduced it into the screening of anticancer drugs. [30][31][32][33] In this work, a novel resonance light scattering amplification system was developed to detect trace amounts of BD in surface water. In the presence of CTMAB, small concentration changes of BD would induce an obvious increase of RLS intensity.…”
Anthracyclines are one of the most studied anticancer drugs approved for medical treatment. The equilibrium constant (K) of reaction between those drugs with DNA in both in-vitro and in-vivo experiments...
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