In this era, stress is the main etiological factor behind almost every other disease. In 2020, the COVID-19 pandemic led to a notable increase in anxiety and depressive disorders worldwide. This highlighted the critical need for mental health support during such challenging times. Ageing is a biological process characterized universally by natural degeneration, standing out as a significant risk factor for morbidity and mortality. The Oxidative Stress Theory suggests that mitochondria play a significant role in the ageing process, identifying them as one of the primary organelles involved. In Ayurveda, it is believed that Mana is the integral part of life, which influences the overall health in general. Ayurvedic text describes Rasayana therapy to rejuvenate and nourish the body and mind. According to Classical Ayurvedic texts, Rasayana therapy can bestow longevity, enhanced memory, rejuvenation, etc. Medhya Rasayana herbs are specifically mentioned for power of memory and retention in human beings. Aim and objective of this review study is to establish the role of Guduchyadi Rasayana in mental well-being. Classical texts of Ayurveda, along with the WHO website and approximately 10 other diverse databases, were systematically searched and reviewed. In total 10 studies have been done and registered on Guduchyadi Rasayana till date. Some of them are carried out in reference to mental disorders whereas few others are done on its effect in other systemic diseases viz., Amlapitta, HTN, Gadgada etc. It is effective in enhancement of memory, cognition and overall status of mental health and has anti-stress, anxiolytic, antidepressant, nootropic, tranquilizing, sedative and anti-oxidative properties.