An insight on topically applied formulations for management of various skin disorders

Jain, Amit; Jain, Sakshi; Abourehab, Mohammed A.S.; Mehta, Parul; Kesharwani, Prashant

doi:10.1080/09205063.2022.2103625

Cited by 17 publications

(8 citation statements)

References 129 publications

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“…These treatments manage rosacea symptoms but do not address the underlying immune dysregulation and vascular dysfunction associated with the disease ( 30 ). Therefore, there is a need for novel, macrophage-targeted therapies that can address the root cause of rosacea ( 65 ). A potential macrophage-targeted therapy for rosacea involves using inhibitors that target pro-inflammatory cytokine production ( 66 ), such as IL-1β, by macrophages.…”

Section: Progress and Challenges In Macrophage-targeted Therapies For...mentioning

confidence: 99%

“…In vitro assays and preclinical animal models can assess macrophage-targeted therapies’ efficacy and safety for rosacea ( 78 ), paving the way for the development of new treatments for this chronic skin disorder ( 79 ). Several clinical trials have investigated the efficacy of macrophage-targeted therapies for the treatment of rosacea ( 65 ). Table 3 summarizes trials with anakinra, canakinumab, and an AhR agonist, comparing current rosacea treatments.…”

Section: Progress and Challenges In Macrophage-targeted Therapies For...mentioning

confidence: 99%

“…In addition, the use of preclinical animal models and clinical trials will be critical for evaluating the safety and efficacy of macrophage-targeted therapies and for identifying new molecular targets for therapy ( 150 ). Ultimately, the development of new macrophage-targeted therapies and a deeper understanding of macrophage function in rosacea may lead to improved treatments and outcomes for patients with this chronic skin disorder ( 65 ).…”

Section: Future Directionsmentioning

confidence: 99%

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The role of macrophages in rosacea: implications for targeted therapies

Liu,

Zhou,

Chu

et al. 2023

Front. Immunol.

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IntroductionRosacea, a widespread chronic skin condition, may be influenced by macrophages, key immune cells in the skin, although their exact role is not yet fully understood. This review delves into the function of macrophages, their potential contribution to rosacea pathogenesis, current treatments, and promising macrophage-targeted therapies. It concludes by identifying knowledge gaps and potential areas for future rosacea research.MethodLeveraging systematic and narrative literature review techniques, we conducted a comprehensive search of databases such as PubMed, Embase, and Web of Science. Utilizing keywords like “rosacea” and “macrophages”, we targeted English articles from the last 5 years (2018-2023). We manually checked reference lists of relevant articles for additional studies. We included only articles emphasizing macrophages’ role in rosacea and/or the development of related therapies and published within the specified timeframe.ResultsThe systematic search of electronic databases yielded a total of 4,263 articles. After applying the inclusion and exclusion criteria, 156 articles were selected for inclusion in this review. These articles included original research studies, review articles, and clinical trials that focused on the role of macrophages in rosacea and/or the development of macrophage-targeted therapies for the disease. The selected articles provided a comprehensive and up-to-date overview of the current state of research on macrophages in rosacea, including their function in the skin, the potential mechanisms through which they may contribute to rosacea pathogenesis, and the current treatments and therapies available for the disease. Additionally, the articles identified gaps in knowledge regarding the role of macrophages in rosacea and suggested potential areas for future research.ConclusionThis literature review emphasizes the important role that macrophages, vital immune cells in the skin, may play in the pathogenesis of rosacea, a common chronic inflammatory skin disorder. The selected studies suggest potential mechanisms by which these cells might contribute to rosacea progression, although these mechanisms are not yet fully understood. The studies also spotlight current rosacea treatments and illuminate the promising potential of new macrophage-focused therapies. Despite these insights, significant gaps persist in our understanding of the precise role of macrophages in rosacea. Future research in this area could provide further insights into the pathogenesis of rosacea and contribute to the development of more effective, targeted therapeutic strategies.

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Section: Progress and Challenges In Macrophage-targeted Therapies For...mentioning

confidence: 99%

Section: Progress and Challenges In Macrophage-targeted Therapies For...mentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

The role of macrophages in rosacea: implications for targeted therapies

Liu,

Zhou,

Chu

et al. 2023

Front. Immunol.

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“…28,29 Traditional formulations may cause skin irritation due to their composition, occlusive nature, or interactions with the skin barrier. 30 However, SLNs, with their biocompatible lipid matrix, offer a promising avenue to alleviate these concerns. 31,32 Formulation optimization involves navigating a complex landscape of variables, where the interplay of factors can significantly impact the desired outcomes.…”

Section: Introductionmentioning

confidence: 99%

Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model

Aydin,

Sagiroglu,

Ozturk Civelek

et al. 2024

IJN

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Background: Curcuma longa L., commonly known as turmeric, is renowned for its therapeutic benefits attributed to bioactive compounds, namely curcumin (Cur) and aromatic turmerone (Tur), present in its rhizome. These compounds exhibit diverse therapeutic properties, including anti-inflammatory, antioxidant, and anti-tumor effects. However, the topical application of these compounds has a significant potential for inducing skin irritation. This study focuses on formulating solid lipid nanoparticle (SLN) carriers encapsulating both Cur and Tur for reduced irritation and enhanced stability. Methods: SLN formulations were prepared by a method using homogenization followed by ultrasonication procedures and optimized by applying response surface methodology (RSM). Results:The optimized SLN formulation demonstrated entrapment efficiencies, with 77.21 ± 4.28% for Cur and 75.12 ± 2.51% for Tur. A size distribution of 292.11 ± 9.43 nm was obtained, which was confirmed to be a spherical and uniform shape via environmental scanning electron microscopy (ESEM) images. The in vitro release study indicated cumulative releases of 71.32 ± 3.73% for Cur and 67.23 ± 1.64% for Tur after 24 hours under sink conditions. Physical stability tests confirmed the stability of formulation, allowing storage at 4°C for a minimum of 60 days. Notably, in vitro skin irritation studies, utilizing the reconstructed human epidermal model (EPI-200-SIT), revealed a significant reduction in irritation with the SLN containing Cur and Tur compared to nonencapsulated Cur and Tur. Conclusion: These findings collectively endorse the optimized SLN formulation as a favorable delivery system for Cur and Tur in diverse topical uses, offering enhanced stability, controlled release and reduced irritation.

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“…[7][8][9][10] The topical route for the management of skin disorders offers several advantages over the oral route and has tremendous potential for successful drug delivery. Topical dosage forms like ointments and cream have disadvantage like irritant to the skin, low spreadability on the skin and less stability [11][12][13] . Due to some of these drawbacks's preparation of nanoemulsion based gel formulation has taken over pharmaceutical as well as cosmeceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Nanoemulgels for the Topical Drug Delivery of Posaconazole

Priyadarshini

Karwa²,

Syed³

et al. 2023

J. Drug Delivery Ther.

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Objective: Posaconazole(POS) is an antifungal drug widely used in treatment of fungal infections. However, the drug has very low oral bioavailability due to high first-pass metabolism, thereby limiting its therapeutic effectiveness. The present study is aimed to prepare nanoemulsion of posaconazole to increase its solubility and to develop posaconazole-loaded nanoemulsion based gel for single dose topical administration to sustain the release of the drug, improve patient compliance and avoid repeated administration. Method:-FTIR-study was performed to determine compatibility of drug with excipients. Pseudoternary-phase diagram was constructed to optimize the Smix ratio. Optimization of nanoemulsion was done by Box-Behnken Design. The optimized formulation was evaluated for particle-size (nm), polydispersity index (PDI), (%) drug content and in-vitro drug release. POS-nanoemulgel (FNG) was developed using carbopol-934P (1%), which was evaluated for homogeneity, pH, viscosity, spreadability, percentage-yield and in-vitro drug release. The anti-fungal activity of POS-nanoemulgel was evaluated against Candida Albicans. Results: The FTIR-study confirmed that there was no interaction between drug and excipients. The optimized selected nanoemulsion (FN1) exhibited particle size 79.19nm, PDI 0.357, drug content 95.90% and in-vitro release of 79.40% at 24 hour. The prepared nanoemulgel was homogenous, opaque with good spreadability 13.91±1.19, viscosity 3760±0.014, pH 5.6±0.06 and the zeta-potential was -29mV, indicating good stability. The drug release at 24h was 72.01%. Further, the developed nanoemulgel formulation exhibited better antifungal activity in comparison to the pure drug gel. Conclusion: Hence, it can be concluded that nanoemulgel of posaconazole can provide better antifungal activity and improve patient compliance. Keywords: Nanoemulsion, Nanoemulgel, Posaconazole, Anti-fungal, Box-Behnken Design, Pseudoternary phase diagram.

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An insight on topically applied formulations for management of various skin disorders

Cited by 17 publications

References 129 publications

The role of macrophages in rosacea: implications for targeted therapies

The role of macrophages in rosacea: implications for targeted therapies

Development of Curcumin and Turmerone Loaded Solid Lipid Nanoparticle for Topical Delivery: Optimization, Characterization and Skin Irritation Evaluation with 3D Tissue Model

Formulation and Evaluation of Nanoemulgels for the Topical Drug Delivery of Posaconazole

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