An insight into the synergistic and mechanistic aspects of (IrCl3 + PdCl2) bimetallic and IrCl3, PdCl2 individual catalysts on oxidation-kinetics of kojic acid with alkaline chloramine-T

Oxidation is a prominent degradation route of biological molecules that produces a wide variety of degradation products through complex mechanisms and hence qualifies to be a vital pharmaceutical process. This article presents the kinetic and spectral study of the oxidation of an antimigraine drug rizatriptan benzoate (RTB) in an acid medium with the aid of a mild biocidal oxidant N-chloro-p-toluenesulfonamide, referred to as chloramine-T (CAT). The kinetic experimental studies reported here, such as fractional order dependency on RTB, pseudo-first-order dependency on CAT, negative fractional order dependency on the acid medium, independent of the rate on the ionic concentration and increasing rate with increasing dielectric constant, have led to the evaluation of stoichiometry, thermodynamic properties, and derivation of a rate equation. Effective interpretation of UV–Vis, IR, 1H and 13C NMR investigation was performed to identify and confirm the identity of the oxidation products and discuss the involved plausible mechanism. This study provides an extended insight into the products of oxidation formed during the metabolism of RTB.

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An insight into the synergistic and mechanistic aspects of (IrCl3 + PdCl2) bimetallic and IrCl3, PdCl2 individual catalysts on oxidation-kinetics of kojic acid with alkaline chloramine-T

Cited by 2 publications

References 22 publications

Donepezil oxidation: complementary chemical and spectroscopic exploration of products, mechanism and kinetics

Donepezil oxidation: complementary chemical and spectroscopic exploration of products, mechanism and kinetics

Chloramine-T-induced oxidation of Rizatriptan Benzoate: An integral chemical and spectroscopic study of products, mechanisms and kinetics

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An insight into the synergistic and mechanistic aspects of (IrCl3 + PdCl2) bimetallic and IrCl3, PdCl2 individual catalysts on oxidation-kinetics of kojic acid with alkaline chloramine-T

Cited by 2 publications

References 22 publications

Donepezil oxidation: complementary chemical and spectroscopic exploration of products, mechanism and kinetics

Donepezil oxidation: complementary chemical and spectroscopic exploration of products, mechanism and kinetics

Chloramine-T-induced oxidation of Rizatriptan Benzoate: An integral chemical and spectroscopic study of products, mechanisms and kinetics

Contact Info

Product

Resources

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An insight into the synergistic and mechanistic aspects of (IrCl3 + PdCl2) bimetallic and IrCl3, PdCl2 individual catalysts on oxidation-kinetics of kojic acid with alkaline chloramine-T