An insight into the sprawling microverse of microRNAs in depression pathophysiology and treatment response

Roy, Bhaskar; Dwivedi, Yogesh K.

doi:10.1016/j.neubiorev.2023.105040

Cited by 7 publications

(3 citation statements)

References 96 publications

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“…To establish conceptual clarity , the definitions of “response” or “predictive” biomarkers were used as per the FDA-NIH criteria [ 48 ]. To establish biological plausibility , only those molecules that had been identified as markers or predictors of treatment response in depression in previous systematic reviews and meta-analyses were included [ 50 , 51 , 52 , 53 , 54 ]. Papers published in English.…”

Section: Review Processmentioning

confidence: 99%

“…Response biomarkers for antidepressant therapies fall broadly into five categories: imaging, electrophysiology, cognition, biochemical, and genetic [ 52 , 53 ]. More recently, novel biomarkers such as levels of specific microRNAs or measures of DNA methylation have also been studied in relation to treatment response in depression [ 54 ]. In terms of the strength of evidence for each of these groups of biomarkers, large effect sizes (combined Hedge’s d > 1) have been noted for imaging, electrophysiology, cognitive and protein/nucleotide markers, and small to moderate effective sizes (combined Hedge’s d = 0.5) for genetic markers.…”

Section: Introductionmentioning

confidence: 99%

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Are There Biological Correlates of Response to Yoga-Based Interventions in Depression? A Critical Scoping Review

Rajkumar

2024

Brain Sciences

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Depression is the most common mental disorder worldwide. Both antidepressants and psychotherapy are effective in treating depression, but the response to these treatments is often incomplete. Yoga-based interventions (YBIs) have been advocated by some researchers as a promising form of alternative treatment for depression. Recent research has attempted to identify the biological mechanisms associated with the antidepressant actions of YBIs. In this scoping review, conducted according to the PRISMA-ScR guidelines, the PubMed and Scopus databases were searched to retrieve research on biomarkers of response to YBIs in patients with depression. These studies were also critically reviewed to evaluate their methodological quality and any sources of bias. Nineteen studies were included in the review. Based on these studies, there is preliminary evidence that YBIs may be associated with increased serum brain-derived neurotrophic factor (BDNF) and reduced serum cortisol and interleukin-6 (IL-6) in patients with depression. However, many of these changes were also observed in the control arms, and the overall quality of the research was low. At present, it cannot be concluded that there are reliable biomarkers of response to YBIs in depression, though there are some potential biological correlates. Further advances in this field will depend critically on improvements in study design, particularly the minimization of sources of bias and the selection of more specific and sensitive biomarkers based on existing evidence from other treatment modalities.

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Section: Review Processmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are There Biological Correlates of Response to Yoga-Based Interventions in Depression? A Critical Scoping Review

Rajkumar

2024

Brain Sciences

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“…Specifically, they serve as biomarkers for diagnosing depression and anxiety and tracking therapeutic responses to these conditions [ 10 ]. A lot of recent research has proved the relationship between ncRNAs and depression [ 11 , 12 ]. For instance, siRNA can be an effective experimental tool to study depression [ 13 ].…”

Section: Introductionmentioning

confidence: 99%