An insight into the sialome of the oriental rat flea, Xenopsylla cheopis (Rots)

Andersen, John F.; Hinnebusch, B. Joseph; Lucas, David A.; Conrads, Thomas P.; Veenstra, Timothy D.; Pham, Van My; Ribeiro, José M. C.

doi:10.1186/1471-2164-8-102

Cited by 69 publications

(79 citation statements)

References 84 publications

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“…aegypti, calreticulins, fibrinogen/fibronectins, serpins, phosphatidylethanolamine-binding proteins, odorant-binding proteins, alkaline phosphatases, lectins, and hydrolases are expressed in both the male AG/ED and the female salivary glands (Valenzuela et al, 2002;. Genes encoding proteins in these classes are also expressed in the salivary glands and digestive tracts of other blood-feeding arthropods (Jaworski et al, 1995;Ribeiro et al, 2004;Arca et al, 2005;Andersen et al, 2007).…”

Section: 5g Novel Proteins-eight Of the Putativementioning

confidence: 99%

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Sirot

Poulson

McKenna

et al. 2008

Insect Biochemistry and Molecular Biology

152

166

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Male reproductive gland proteins (mRGPs) impact the physiology and/or behavior of mated females in a broad range of organisms. We sought to identify mRGPs of the yellow fever mosquito, Aedes aegypti, the primary vector of dengue and yellow fever viruses. Earlier studies with Ae. aegypti demonstrated that "matrone" (a partially purified male reproductive accessory gland substance) or male accessory gland fluid injected into virgin female Ae. aegypti affect female sexual refractoriness, blood feeding and digestion, flight, ovarian development, and oviposition. Using bioinformatic comparisons to Drosophila melanogaster accessory gland proteins and mass spectrometry of proteins from Ae. aegypti male accessory glands and ejaculatory ducts (AG/ED) and female reproductive tracts, we identified 63 new putative Ae. aegypti mRGPs. Twenty-one of these proteins were found in the reproductive tract of mated females, but not of virgin females, suggesting that they are transferred from males to females during mating. Most of the putative mRGPs fall into the same protein classes as mRGPs in other organisms, although some appear to be evolving rapidly and lack identifiable homologs in Culex pipiens, Anopheles gambiae, and D. melanogaster. Our results identify candidate male-derived molecules that may have an important influence on behavior, survival and reproduction of female mosquitoes.

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Section: 5g Novel Proteins-eight Of the Putativementioning

confidence: 99%

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Sirot

Poulson

McKenna

et al. 2008

Insect Biochemistry and Molecular Biology

152

166

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“…Although the wide phylogenetic spread of CSαβ defensins has led some authors to propose a common and very ancient origin of these peptides (53,175), the high sequence variation prevents reliable phylogenetic reconstructions (39). Nonetheless, bona fide CSαβ defensin peptides (i.e., those with immune-related function) have been identified in the hematophagous secretion glands of ticks and insects (e.g., 9,14,150,172). Proteins that show remarkable similarity to tick defensins (more than 80% similarity) have been found in scorpion hemolymph (46), supporting a paralogous relationship between CSαβ defensins and scorpion neurotoxins (37).…”

Section: Figurementioning

confidence: 99%

“…Related proteins have been convergently recruited in the feeding secretion of animals from hematophagous taxa in three distinct insect orders: Diptera [mosquitoes (12), sandflies (75), biting midges (26), tsetse flies (86), and muscid flies (4)], Hemiptera [triatomine bugs (129)], and Siphanoptera [fleas (9)]. Within some of these taxa, multiple isoforms are present, contributing to a complex feeding-secretion protein mixture.…”

Section: Cap [Cysteine-rich Secretory Proteins (Crisp) Antigen 5 (Agmentioning

confidence: 99%

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

Fry

Roelants

Champagne

et al. 2009

Annu. Rev. Genom. Hum. Genet.

712

778

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Throughout evolution, numerous proteins have been convergently recruited into the venoms of various animals, including centipedes, cephalopods, cone snails, fish, insects (several independent venom systems), platypus, scorpions, shrews, spiders, toxicoferan reptiles (lizards and snakes), and sea anemones. The protein scaffolds utilized convergently have included AVIT/colipase/prokineticin, CAP, chitinase, cystatin, defensins, hyaluronidase, Kunitz, lectin, lipocalin, natriuretic peptide, peptidase S1, phospholipase A 2 , sphingomyelinase D, and SPRY. Many of these same venom protein types have also been convergently recruited for use in the hematophagous gland secretions of invertebrates (e.g., fleas, leeches, kissing bugs, mosquitoes, and ticks) and vertebrates (e.g., vampire bats). Here, we discuss a number of overarching structural, functional, and evolutionary generalities of the protein families from which these toxins have been frequently recruited and propose a revised and expanded working definition for venom. Given the large number of striking similarities between the protein compositions of conventional venoms and hematophagous secretions, we argue that the latter should also fall under the same definition. 483

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“…Tsetse flies show a predominance of the endonuclease family [27,28] . Expansion of the acid phosphatase and FS1 antigen families occurred in fleas [21] . The odorant-binding/D7 family expanded in bed bugs, mosquitoes, sand flies, and biting midges .…”

Section: The Same Protein Families Are Prone To Expansion In Closely mentioning

confidence: 99%

Evolution of Vertebrate Hemostatic and Inflammatory Control Mechanisms in Blood-Feeding Arthropods

Mans¹

2010

J Innate Immun

101

103

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Arthropods evolved blood-feeding lifestyles on more than 20 independent occasions. A comparison of sialomes (secretory salivary gland protein family repertoires) corroborates this and indicates that unique protein families are found for different blood-feeding lineages. Closely related lineages considered to have evolved blood-feeding behavior independently might share similar sets of protein families in their sialomes. No orthologous relationships or conserved functional mechanisms have, however, been found for these apparently related protein family members. This implies that sialomes were already defined before the divergence of these related lineages, but that the functions involved in blood feeding evolved at a later stage. Protein families prone to lineage-specific expansion (gene duplication) tend to be abundant with specialized functions associated with various gene duplicates. A central theme that seems to emerge from comparative sialomic analysis is that of the convergent evolution of modulatory strategies that targets host defenses even if the molecular mechanisms differ.

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An insight into the sialome of the oriental rat flea, Xenopsylla cheopis (Rots)

Cited by 69 publications

References 84 publications

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

Evolution of Vertebrate Hemostatic and Inflammatory Control Mechanisms in Blood-Feeding Arthropods

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