An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis

Emiralioğlu, Nagehan; Yenicesu, İdil; Sarı, Sinan; Eğritaş, Ödül; Poyraz, Aylar; Paşaoğlu, Özge Tuğçe; Çelik, Bülent; Dalgıç, Buket

doi:10.1007/s00431-014-2482-4

Cited by 15 publications

(15 citation statements)

References 36 publications

(51 reference statements)

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“…Several studies from different countries recently reported a positive association between H. pylori infection and iron deficiency anemia (IDA) [43][44][45], and several factors, including hypochlorhydria, pro-hepcidin, and hepcidin may possibly affect this hematological condition [45,46]. Another recent study also demonstrated a significant improvement of some IDA status indices, including mean corpuscular volume and transferrin, following H. pylori eradication in children from Egypt [47].…”

Section: Hematological Diseases Iron Deficiency Anemiamentioning

confidence: 99%

Extragastric Diseases and Helicobacter pylori

Franceschi¹,

2015

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The extragastric manifestations of Helicobacter pylori infection still remain a very strong topic throughout the H. pylori world. Indeed, H. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that H. pylori may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions. Different pathogenic mechanisms have been hypothesized, including the induction of a low-grade inflammatory state and the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic in the last year.There is a very strong interest of researchers from all over the world in the extragastric manifestations of Helicobacter pylori infection, as demonstrated by the high number of studies published in this field during the last year. Indeed, H. pylori is a very good model for studying host-bacterial interactions and very attractive for those interested in the role of gut microbiota in health and disease [1]. Here, we shall summarize the results of the most relevant studies published on this topic from

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Section: Hematological Diseases Iron Deficiency Anemiamentioning

confidence: 99%

Extragastric Diseases and Helicobacter pylori

Franceschi¹,

2015

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“…On the other hand, the prevalence of H. pylori infection was shown to be significantly higher in children with IDA compared to nonanemic sex‐ and age‐matched patients (81.3% vs 14.3%; P <.0001) . Concerning the possible mechanism of action, Emiralioglu et al . reported a correlation between H. pylori infection, gastric inflammation, and increased levels of prohepcidin and reduced levels of ferritin, while Hacibekiroglu et al .…”

Section: Hematologic Diseasesmentioning

confidence: 99%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro-gynecologic diseases, as well as diabetes mellitus and metabolic syndrome, with very promising results. This review has been aimed at summarizing the results of the most relevant studies published over the last year on this fascinating topic.

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“…These children had increased levels of mucosal IL‐1beta expression and increased fasting intragastric pH compared to the noninfected, their results are limited by the very small number of cases. Similarly, the study by Emiralioglu et al . looking at the relation of prohepcidin, IDA, and IL‐6 is limited by the fact that only 6 of 50 H. pylori ‐infected children were anemic.…”

Section: Clinical Presentationmentioning

confidence: 99%

Helicobacter pylori in children

2016

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Helicobacter pylori infection in early childhood may differ in many aspects compared to infection in adulthood: the immune response in the gut, the type and prevalence of complications within and outside the stomach, and the impact on long-term health. In high prevalence countries, transient infections seem to be common in infants and toddlers, and the consequences of this phenomenon on the short- and long-term immune response are still unclear. Other controversial issues are related to the question of which H. pylori-infected children benefit from treatment and which is the best regimen to eradicate the infection in the presence of a worldwide increasing antibiotic resistance. The first large-scale randomized placebo-controlled vaccination trial in schoolchildren indicates that prevention of the infection may be possible.

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An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis

Abstract: H. pylori-induced gastritis appears to cause an increase in prohepcidin levels and a decrease in ferritin levels, supporting our hypothesis; but this relationship has not been proven.

Cited by 15 publications

References 36 publications

Extragastric Diseases and Helicobacter pylori

Extragastric Diseases and Helicobacter pylori

Helicobacter pylori and extragastric diseases

Helicobacter pylori in children

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