An insight into the placental morphology in a case of Edwards syndrome

Abstract

Certain histomorphological features of the placenta can suggest, although not diagnose, the presence of abnormal karyotype in cases of chromosomal anomalies in the fetus. However, data correlating placental histology and abnormal fetal karyotype is scarce. Here, in this article, we wanted to enlighten the readers about the importance of the placental morphology in chromosomal aberrations by presenting a case of a 22-year-old primigravida who at 8 weeks of gestation had a regular prenatal check-up. Over a period of time, the ultrasound study at 21 weeks of gestation revealed a single live intrauterine fetus in a breech position with polyhydramnios, strawberry-shaped skull, and other features. Amniocentesis revealed that the fetus was having Edwards syndrome (trisomy 18). The placental examination showed areas of sclerosis and congestion with a single umbilical artery.