An insight into the determination of size and number concentration of silver nanoparticles in blood using single particle ICP-MS (spICP-MS): feasibility of application to samples relevant to in vivo toxicology studies

Abstract

Toxicological studies concerning nanomaterials in complex biological matrices usually require a carefully designed workflow that involves handling, transportation and preparation of a large number of samples without affecting the nanoparticle...

Method development for speciation analysis of silver nanoparticles and silver ions in green algae and surface waters at environmentally relevant concentrations using single particle ICP-MS

“…The differences in silver recovery values are related to the ICP-MS response for Ag( i ), which was significantly higher for solutions prepared in TMAH + Triton X-100 and TMAH digests + Triton X-100 (by 56% and 51%, respectively) in comparison to the response in Triton X-100. The enhancement of the Ag( i ) sensitivity in the presence of TMAH was also observed by Abad-Alvaro et al 20 Although the silver recovery was dependent on the calibration medium, the sizes of AgNPs extracted from cells were similar in the three calibration methods (the mean size was 74 ± 1 nm for samples spiked with 75 nm AgNPs and 62 ± 1 nm for samples spiked with 60 nm AgNPs) (Table 2S†).…”

“…As can be seen in Table 1, the analytical parameters obtained with both calibration approaches are very similar. The calculated LOD size (20 nm) is comparable to that obtained by Abad-Alvaro et al 20 (19 nm). Limits of quantification for AgNPs (calculated as 3 LOD) were 2.9·10 6 particles per L (1.7·10 5 particles per g) and 0.3 ng L −1 (0.02 ng g −1 ).…”

Living in a transient world: ICP-MS reinvented via time-resolved analysis for monitoring single events

“…Therefore, accurate characterization of real samples should always consider this aspect and make use of suitable strategies to deal with it. That means that, unless some separation is performed, matrix-matching is recommendable, 83 whenever possible.…”

“…Therefore, accurate characterization of real samples should always consider this aspect and make use of suitable strategies to deal with it. That means that, unless some separation is performed, matrix-matching is recommendable, 83 whenever possible. Alternative approaches to counteract the influence of matrix effects on the analytical results, such as calibration via isotope dilution, have also been reported in the literature, but seldom.…”

Single-Molecule Detection of Nucleic Acids via Liposome Signal Amplification in Mass Spectrometry

“…The atomisation efficiency of ICP-MS is limited; typically, it is only 0.5%, with the ICP ionisation process also resulting in the loss of many ions [ 18 ]. However, the flow path of electrospray ionisation mass spectrometry (ESI-MS) is simple [ 19 ].…”