An insight into anti-inflammatory effects of fungal beta-glucans

Du, Bin; Lin, Cheng Yuan; Bian, Zhaoxiang; Xu, Baojun

doi:10.1016/j.tifs.2014.09.002

Cited by 156 publications

(104 citation statements)

References 64 publications

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“…An active wound healing ingredient is beta-glucans (Zykova et al, 2014) which forms a heterogeneous group of polysaccharides build from β-glucose monomers (Figure 1), where the primary structure, molecular weight, branching and polymer charge influence the biological activity and solubility of the β-1,3-glucans (Soltanian et al, 2009). Beta-glucans are currently used in a number of applications ranging from skin care, medicine, and as food supplements due to their immunological (Stier et al, 2014;Novak and Vetvicka, 2008) and anti-inflammatory effects (Du et al, 2015). In this study, we have used a soluble 2.5 % (w/v) beta-glucan (βG), containing β-1,3/1,6 glucan extraction and purification from the cell walls of Baker's yeast (Saccharomyces cerevisiae).…”

Section: Introductionmentioning

confidence: 99%

Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation

Grip

Engstad

Skjæveland

et al. 2017

European Journal of Pharmaceutical Sciences

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Chronic wounds represent a significant health problem worldwide. There is a need for advanced- and cost-efficient wound healing products able to increase patient comfort and reduce the healing time. The aim of this study was to develop a sprayable hydrogel dressing with beta-glucan (βG) as the active ingredient, targeting future application in the treatment of both chronic and burn wounds. The βG was chosen as an active ingredient because of its promising wound healing capabilities, whereas Carbopol 971P NF (Carbopol) was chosen as the thickening agent in the formulation due to several attractive characteristics such as its low viscosity, low toxicity, high transparency and good ion tolerance. Four different hydrogel formulations were prepared with varying Carbopol concentrations. The higher Carbopol concentration, 0.5% (w/w), was used to prepare three formulations comprising the HighCP:NoβG, HighCP:LowβG and the HighCP:MediumβG formulation, respectively. Lower Carbopol concentration, 0.25% (w/w), was used to prepare the LowCP:HighβG formulation. The content of βG varied from 0.25% in the HighCP:LowβG, 0.5% in the HighCP:MediumβG and 1.0% (w/w) in the LowCP:HighβG formulation, respectively. The first part of the study focused on the rheological characterization of the hydrogels and the fluid affinity testing. All formulations were confirmed to be stable gels; the βG was shown to augment the gel strength by increasing the yield strength of the gel in a dose dependent manner. The stability of the formulations containing either Carbopol alone or in a combination with βG did not deteriorate over 26weeks, and the fluid donation and absorption study indicated a fluid donation profile, which favors healing of dry wounds. The in vivo efficacy of the formulations, evaluated in the modified diabetic male mice (db/db mice), showed that Carbopol alone was unable to induce improved healing and caused adverse reactions in some wounds. The inclusion of βG increased the epithelialization and wound contraction in the db/db mice when given at high βG:Carbopol ratio. The positive effect of βG was, however, not sufficient to counteract the adverse effect of Carbopol, thus a more suitable thickening agent should be investigated for further development of a sprayable wound care product.

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Section: Introductionmentioning

confidence: 99%

Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation

Grip

Engstad

Skjæveland

et al. 2017

European Journal of Pharmaceutical Sciences

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“…Heteropolysaccharides also possess biological properties (Datta et al, 2019). Macrofungus-derived β-glucan administration has immunostimulant and antitumor activities (Du, Lin, Bian, & Xu, 2015;Rathore et al, 2017). β-Glucan modulates adaptive and innate immunity ( Figure 3) and has indirect antitumor efficacy (Meng et al, 2016).…”

Section: Macrofungi Active Ingredients and Biological Activitymentioning

confidence: 99%

Macrofungi: A review of cultivation strategies, bioactivity, and application of mushrooms

Lou

et al. 2020

Comp Rev Food Sci Food Safe

112

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The production of macrofungi (mushrooms) as well as their economic value have been steadily increasing globally. The use of functional foods, dietary supplements, and traditional medicines derived from macrofungi is increasing as they have numerous health benefits as well as abundant nutrients. Macrofungi are diverse with complex and highly varied growth conditions and bioactive constituents, most macrofungal resources have not yet been fully explored and applicated, leading to an urgent need for appropriate strategies to address the problem. Increasing attention has been paid to the macrofungal cultivation and application, in particular, potential prebiotics. Herein, the present review comprehensively summarizes recent progress in the cultivation, newly identified bioactive constituents, and their effects on gut microbiota as well as the potential ways in which they affect human health. Moreover, the macrofungal food development is discussed to improve food nutritional value and change the quality characteristics of food. Finally, the review addresses consumer safety concerns and the prospective genetic manipulation of macrofungi. We hope that this review can provide a comprehensive research reference for ensuring the safety and efficacy, along with maximizing the value and profitability of macrofungi production.

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“…It is well reported that β-glucans can be of use in a wide variety of industrial applications including food supplements, pharmaceuticals, cosmetics, chemicals, food and feed industries [5]. Specifically, considering their biomedical attributes, β-glucans provide antioxidant properties [13], radical scavenging, antitumor, anti-inflammatory, antimicrobial, cardiovascular, but also antidiabetic and liver-protecting effects [5,14,15]. Consequently, research efforts are focusing on the elucidation of their biological roles, along with the design of new drugs or dietary supplements based on β-glucan as the active ingredient [16].…”

Section: Glucansmentioning

confidence: 99%

Biocatalytic Synthesis of Fungal β-Glucans

Papaspyridi

Zerva

2018

Catalysts

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Glucans are the dominant polysaccharide constituents of fungal cell walls. Remarkably, these major bioactive polysaccharides account for the beneficial effects that have been observed by many mushrooms of medicinal interest. Accordingly, the prevailing tendency is the use of bioactive mushroom β-glucans mainly in pharmaceutical industries or as food additives, since it seems that they can be involved in meeting the overall growing demand for food in the future, but also in medical and material sectors. β-(1,3)-Glucan synthase (GLS) is the responsible enzyme for the synthesis of these important polysaccharides, which is a member of the glycosyl transferase (GT) family. For optimizing the production of such natural polymers of great interest, the comprehension of the fungal synthetic mechanism, as well as the biochemical and molecular characteristics of the key enzyme GLS and its expression seem to be crucial. Overall, in this review article, the fungal β-glucans biosynthesis by GLS is summarized, while the in vitro synthesis of major polysaccharides is also discussed, catalyzed by glycoside hydrolases (GHs) and GTs. Possible future prospects of GLS in medicine and in developing other potential artificial composite materials with industrial applications are also summarized.

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An insight into anti-inflammatory effects of fungal beta-glucans

Cited by 156 publications

References 64 publications

Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation

Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation

Macrofungi: A review of cultivation strategies, bioactivity, and application of mushrooms

Biocatalytic Synthesis of Fungal β-Glucans

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