Enoxaparine is a thromboembolic drug that should be learned by subcutaneous self-administration in patients who use it regularly. The aim of this study is to examine the most watched videos about the application of enoxaparine on Youtube in terms of quality, reliability, usefulness and comprehensiveness. The reason for examining the videos of the broadcasts on Youtube in the study is that Youtube is a digital information source that people can access easily. In the evaluation of the videos, the video power index was calculated based on both views and likes. The quality of the videos was evaluated according to the Global Quality Score-GQS score, and the reliability was evaluated according to the DISCERN scale scores. A total of 400 videos were watched in the study and analyzes were carried out with the remaining 34 videos after the exclusion criteria. 16 of these videos were uploaded by patients, 13 by healthcare professionals, and 5 by other individuals/institutions. 25 (73.5%) of the videos contain useful information and 9 (26.5%) misleading information. According to the quality scores of the videos calculated by GQS scoring, 15 were low, 6 were medium, and 13 were high quality videos. It was determined that the reliability and comprehensiveness scores of the videos were moderate. The results of the research revealed that Youtube videos are not an adequate instructional resource regarding the quality, safety and comprehensiveness of teaching self-injection of enoxaparine.