An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy

Abstract

A kind of inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion, was developed for selective cancer therapy with high efficacy.

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

“…6À reacted by hydrogen peroxide (H 2 O 2 ) in tumor tissues for selective cancer chemotherapy. 34 Due to the high atomic number Z of Te (52), it is easy to transit electrons in the outer layer by forming electron holes and producing ROS under X-ray irradiation, thereby enhancing the sensitivity of tumor cells to X-rays. Thus, we speculate that Te-based nanomaterials can be developed as effective radiosensitizers to enhance the efficacy of RT.…”

In Vivo X‐ray Triggered Catalysis of H2 Generation for Cancer Synergistic Gas Radiotherapy

“…Thus, the primary DNA damage was attributed to the ROS generated during the radiotherapy process. Here, the ROS probe, 2,7‐dichlorodihydrofluorescein diacetate (DCFH‐DA), [19] was used to detect the ROS content, which was proportional to the green fluorescence detected in the cells incubated with different materials after X‐ray irradiation (Figure 3 d). The green fluorescence of the solution corresponding to Au‐TiO 2 @ZnS under X‐ray irradiation was greatly increased compared with that of the control group.…”

“…Thec ell cycler esults indicated that after X-ray irradiation, the G2-M cycle of MC38 cells was blocked to inhibit cell proliferation (Figure S10). Theresults of the TUNEL experiment showed that ag reat number of DNAf ragments appeared in the X-ray group,w hich are represented by bright green FITC fluorescence in Figure 3c,e specially in the Au-TiO 2 @ZnS coincubation group.T hus,t he primary DNAd amage was attributed to the ROSg enerated during the radiotherapy process.H ere,t he ROSp robe,2 ,7-dichlorodihydrofluorescein diacetate (DCFH-DA), [19] was used to detect the ROS content, which was proportional to the green fluorescence detected in the cells incubated with different materials after X-ray irradiation (Figure 3d). Theg reen fluorescence of the solution corresponding to Au-TiO 2 @ZnS under X-ray irradiation was greatly increased compared with that of the control group.T his indicates that under the condition of X-ray irradiation and Au-TiO 2 @ZnS co-incubation, the cells produced al arge amount of ROS.…”

Anisotropic transition metal–based nanomaterials for biomedical applications

“…reported a new kind of inorganic nanoprodrug, tellurium nanowires (TeNWs), which could cause TeO 6 6− for tumor chemotherapy with high selectivity. [ 43 ] The reaction of TeNWs and intracellular H 2 O 2 ‐produced toxic TeO 6 6− thus enhanced the tumor ROS level. In addition, the glutathione (GSH) inside of tumor cells could react with the obtained TeO 6 6− and decrease the level of GSH and in another aspect increase the ROS levels in the tumor.…”