2010
DOI: 10.1590/s0103-50532010000700026
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An inorganic complex that inhibits Mycobacterium tuberculosis enoyl reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis

Abstract: Descrevemos a atividade inibitória do IQG607, pentaciano(isoniazida)ferrato(II), frente a cepas de Mycobacterium tuberculosis tanto resistentes quanto sensíveis à isoniazida, assim como a toxicidade oral e a adaptação da síntese química do IQG607 para reatores maiores. O IQG607 representa um potencial agente quimioterápico que inibe um alvo molecular definido.Here we describe the inhibitory activity of IQG607, pentacyano(isoniazid)ferrate(II), on isoniazid-sensitive and isoniazid-resistant strains of Mycobacte… Show more

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Cited by 23 publications
(25 citation statements)
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“…These findings challenge its planned usage against INH-resistant strains. Nonetheless, the compound has already been reported to be less toxic than INH in a preclinical study using mice (5,24). This is a remarkable feature, since INH was previously associated with hepatotoxicity in animal and humans due to its toxic metabolites, such as hydrazine (25).…”
mentioning
confidence: 99%
“…These findings challenge its planned usage against INH-resistant strains. Nonetheless, the compound has already been reported to be less toxic than INH in a preclinical study using mice (5,24). This is a remarkable feature, since INH was previously associated with hepatotoxicity in animal and humans due to its toxic metabolites, such as hydrazine (25).…”
mentioning
confidence: 99%
“…Pentacyanoferrate(II)-isonicotinoylhydrazones 4a-e were prepared by a similar procedure used before for the 3-was synthesized from sodium nitroprusside dissolved in ammonium solution followed by NH 3 gas bubbling into the reaction mixture, in accordance with a previously described protocol. 26 The complexes 4a-e were obtained from the reaction between hydrazones 3a-e and aminpentacyanoferrate(II) in water, at room temperature for 10 h, with yields of 76-98% (Scheme 1). The E-stereochemistry of imine-double bond was assigned for both series of compounds based on the magnitude of the imine-proton chemical shifts.…”
Section: Resultsmentioning
confidence: 99%
“…These compounds are not expected to be activated prior to interacting with its cellular target. Within this approach Basso, Moreira, Santos and collaborators [26][27][28][29] have proposed an INH analog, namely pentacyano (isoniazid)ferrate(II) that contains a cyanoferrate moiety, a metal center and the INH ligand [26]. This class of compounds constitutes a suitable model system for new perspectives of novel drug development for the treatment of MDR-TB [27].…”
Section: Introductionmentioning
confidence: 99%