An Inorganic Chick Growth Response

Dannenburg, Warren N.; Reid, B. L.; Rozacky, Eugene Emil; Couch, J. R.

doi:10.3382/ps.0341023

Cited by 19 publications

(4 citation statements)

References 7 publications

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“…The discovery of the practical nutritional importance of zinc for swine was a stimulus for determining the importance of zinc for other agriculturally important animals. In 1955, it was reported that chicks fed a semipurified diet containing soy protein required an unidentified mineral (28,29). O'Dell and Savage (30) suggested that zinc was needed by the growing chick in 1957.…”

Section: Poultrymentioning

confidence: 99%

History of Zinc in Agriculture

Nielsen

2012

Advances in Nutrition

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Zinc was established as essential for green plants in 1926 and for mammals in 1934. However, >20 y would pass before the first descriptions of zinc deficiencies in farm animals appeared. In 1955, it was reported that zinc supplementation would cure parakeratosis in swine. In 1958, it was reported that zinc deficiency induced poor growth, leg abnormalities, poor feathering, and parakeratosis in chicks. In the 1960s, zinc supplementation was found to alleviate parakeratosis in grazing cattle and sheep. Within 35 y, it was established that nearly one half of the soils in the world may be zinc deficient, causing decreased plant zinc content and production that can be prevented by zinc fertilization. In many of these areas, zinc deficiency is prevented in grazing livestock by zinc fertilization of pastures or by providing salt licks. For livestock under more defined conditions, such as poultry, swine, and dairy and finishing cattle, feeds are easily supplemented with zinc salts to prevent deficiency. Today, the causes and consequences of zinc deficiency and methods and effects of overcoming the deficiency are well established for agriculture. The history of zinc in agriculture is an outstanding demonstration of the translation of research into practical application.

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Section: Poultrymentioning

confidence: 99%

History of Zinc in Agriculture

Nielsen

2012

Advances in Nutrition

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“…Wilson & Galton (1971), working with human fat, suggested that fenfluramine may act at the acyl-transfer reaction in the pathway of triglyceride synthesis since it reduced radioactivity in the neutral lipid from labelled palmitate but did not reduce radioactivity in the long chain acyl-CoA fraction. Dannenburg & Kardian (1970) showed that fenfluramine (1 mM) inhibited lipogenesis from [14C I-glucose by reducing fatty acid synthesis from glucose. In my studies, I did not pursue the site of action of norfenfluramine but since glucose uptake is unaffected the effect must be intracellular.…”

Section: Discussionmentioning

confidence: 99%

“…More convincing evidence for the direct action of fenfluramine on adipose tissue is needed and yet very few groups so far have demonstrated the effect of fenfluramine and its derivatives in vitro. Dannenburg & Kardian (1970) have reported metabolic effects of fenfluramine (1 mM) in vitro using rat fat cells, namely the inhibition of hormone-stimulated lipolysis and glyceride-fatty acid and free fatty acid synthesis. Wilson & Galton (1971) showed that fenfluramine at concentrations greater than 1 mM could also inhibit lipogenesis in pieces or homogenates of human adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

A PRELIMINARY STUDY OF THE EFFECT OF NORFENFLURAMINE ON LIPOGENESIS BY HUMAN ADIPOSE TISSUE In vitro

Ashwell¹

1974

Brit J Clinical Pharma

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Norfenfluramine is thought to be the major active metabolite of fenfluramine in man. Therefore its in vitro effect on lipogenesis in human adipose tissue from twelve patients was investigated. Although inhibition of lipogenesis was demonstrated, the concentrations of norfenfluramine necessary (>1 mM) were much higher than normal blood levels of the drug. There was no correlation between the degree of inhibition by norfenfluramine in vitro and fat cell size, age or relative weight of the subject. Greater degrees of inhibition were however associated with samples of tissue from patients with higher blood glycerol concentrations and lower blood triglyceride concentrations.

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“…One example of what appears to be an inadequate salt mixture is that used by Dannenburg et al (1955) who studied an inorganic growth factor present in the ash of distillers' dried solubles. This salt mixture apparently supplied only 0.12% of potassium to the ration (as provided by 0.258% of K 2 HP0 4 and by KI).…”

mentioning

confidence: 99%

Inadequacy of Certain Salt Mixtures Used in Studies of Unidentified Growth Factors for Chicks

Briggs

1956

Poultry Science

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An Inorganic Chick Growth Response

Cited by 19 publications

References 7 publications

History of Zinc in Agriculture

History of Zinc in Agriculture

A PRELIMINARY STUDY OF THE EFFECT OF NORFENFLURAMINE ON LIPOGENESIS BY HUMAN ADIPOSE TISSUE In vitro

Inadequacy of Certain Salt Mixtures Used in Studies of Unidentified Growth Factors for Chicks

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