An innovative electrically conductive biopolymer based on poly(β‐cyclodextrin) towards recognition of ascorbic acid in real sample: Utilization of biocompatible advanced materials in biomedical analysis

Abstract

In this study, a sensitive platform was designed for the electrocatalytical oxidation and recognition of ascorbic acid (AA) based on poly(β-cyclodextrin) modified glassy carbon electrode (p(β-CD-GCE). Electropolymerization of β-CD on the surface of GCE was performed on the potential range of À1 to 1.5 V. So, a novel biopolymer was prepared on the surface of GCE towards sensitive recognition of AA in human plasma samples. The developed platform has good sensitivity and accuracy for electrooxidation and detection of AA with lower limit of quantification (LLOQ) of 1 nM and linear range of 1 nM to 100 mM. Moreover, the designed electrochemical sensor was employed for the analysis of AA on human plasma samples with high sensitivity. Based on advantages of p(β-CD) prepared by electropolymerization procedure (green, fast, homogeny, and efficient eletrocatalytical behaviour), this conductive biopolymer showed excellent analytical behaviour towards electrooxidation of AA. It is expected that the prepared polymeric interface is able to use in the analysis of biological species in clinical samples.

Development of Electro-Reduced AgNPs/MnO2/rGO Composite toward a Robust Sensor for the Simultaneous Determination of Piroxicam and Ofloxacin

“…The obtained slope values, 0.537 and 0.532, indicate the adsorption-controlled process on the electrode surface. Such evidence also suggest that AgNPs/MnO 2 /ErGO-GCE electrode-driven electrochemical reactions involve the diffusion and adsorption-controlled process. − …”

Efficient Entrapment of Alpha-Synuclein Biotinylated Antibody in KCC-1-NH-CS2 and Application for the Sensitive Diagnosis of Parkinson’s Using Recognition of Biomarker: An Innovative Electrochemical Label-Free Immunosensor for the Biomedical Analysis of Neurodegenerative Diseases

“…The polymers formed using this approach do not contain any catalysts or oxidant fragments, and their physical and chemical characteristics are determined by the electrochemical conditions used during formation [ 20 ]. Several articles have been published on the development of biosensors based on the electrodeposition of β-CD on the surface of a GCE, which shows the popularity of this method for the construction of biosensors [ 21 , 22 , 23 , 24 , 25 ].…”

An Innovative Sandwich Type Biosensor towards Sensitive and Selective Monitoring of 2-Arachidonoylglycerol in Human Plasma Samples Using P(β-CD)-AuNPs-DDT as Amplificant Agent: A New Immuno-Platform for the Recognition of Endocannabinoids in Real Samples

“…The peak current rose in subsequent cycles, showing the formation of P( β -CD) on the surface of the CGE. In addition, the current grew quickly up until cycle 28 and then gradually lessened in strength in subsequent cycles, suggesting that the film may have achieved its largest thickness [ 32 , 33 , 34 , 35 ].…”