An innovative approach to improve the performance of a two separate phase enzyme membrane reactor by immobilizing lipase in presence of emulsion

Giorno, Lidietta; D’Amore, E.; Mazzei, Rosalinda; Piacentini, Emma; Zhang, J.; Drioli, Enrico; Cassano, Roberta; Picci, Nevio

doi:10.1016/j.memsci.2007.02.041

Cited by 40 publications

(11 citation statements)

References 13 publications

(15 reference statements)

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“…A further improvement of the biphasic enzyme reactor concept using lipase for enantioselective transformation has been reported by Giorno and co-workers [92], i.e. an emulsion enzyme membrane reactor.…”

Section: Biphasic Enzyme Membrane Systems With Enantioselective Recogmentioning

confidence: 98%

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Molecular Recognition‐Driven Membrane Processes

Donato¹,

Mazzei²,

Algieri³

et al. 2014

Smart Membranes and Sensors

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High-precision, selective and effi cient systems are strongly demanded in all productive sectors, including chemical manufacturing, pharmaceutical, medical treatment, food, energy, diagnostic, analytical tools. Precision separation, conversion, formulation at molecular level may rely on various mechanisms and properties, such as molecular sieving, electrical charge, chemical solubility, molecular recognition. Membrane operation can promote mass transport, separation, conversion, formulation on the basis of the mentioned mechanisms. Biomimic and biohybrid funtionalised membranes are particularly suitable for separations based on molecular recognition.Membranes can be formed by polymers or monolythes bearing the (biomimic) recognition sites. In alternative, biomimic, biomolecules and recognition sites can be loaded on a previously formed membrane support. In such cases, surface functionalization methods can improve the loading effi ciency. Molecularly imprinted membranes; membranes bearing affi nity ligands (Antigen-Antibody, avidin/-ligand, DNA-protein, sugar-lectin, RNA-ribosome,…); membranes functionalized with zeolite and nanoparticles; membranes with immobilized enantioselective enzyme for kinetic resolutions, are among examples of selective and effi cient operations driven by molecular recognition. Th is is the mechanism by means of which molecules are able to identify each other using non-covalent -(hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, π-π interactions and electrostatic eff ects) and covalent interactions.

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Section: Biphasic Enzyme Membrane Systems With Enantioselective Recogmentioning

confidence: 98%

“…Some interesting examples were reported in which the racemic resolution is obtained in a biphasic enzyme membrane systems [91,92]. In this case lipase was immobilized on polymeric membranes to selectively convert S-naproxen esters from racemic mixtures in S-naproxen acid.…”

Section: Biphasic Enzyme Membrane Systems With Enantioselective Recogmentioning

confidence: 99%

Molecular Recognition‐Driven Membrane Processes

Donato¹,

Mazzei²,

Algieri³

et al. 2014

Smart Membranes and Sensors

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“…The TSP-EMR with emulsion optimized distribution of the immobilized enzyme improved the mass transfer. 21 Although the specific activity of the enzyme with and without the emulsion was same, the enantiomeric excess of the product increased from 74% (TSP-EMR) to 97% (TSP-E-EMR) for (R, S)-naproxen methyl ester, and from 96% (TSP-EMR) to 100% (TSP-E-EMR) for racemic naproxen butyl ester, and the overall mass transfer coefficient of the TSP-E-EMR was larger by 58%. 21 However, formation of the emulsion environment on the membrane surfaces may complicate workup, 113 whereas the classic biphasic EMR offers simple operation.…”

Section: Classic or Emulsion Tsp-emrmentioning

confidence: 99%

“…77 Production of (S)-naproxen acid obtained excellent product enantiomeric excess (74-100%), but low conversion values (<10%). 21,52,60,65,72 Candida rugosa lipase (CRL) immobilized on sponge layers of polyamide membranes was operated to hydrolyse the substrate, (R, S)-naproxen ester, dissolved in isooctane at 30…”

Section: Drugs and Intermediatesmentioning

confidence: 99%

“…18 -20 Enzymatic resolution of racemic compounds in membrane reactors (enzymatic membrane reactors or EMR) give many benefits. Conversion and separation of the enantiomers can take place in a single operation, 21,22 thus selective removal of products from reaction sites increases conversion of productinhibited or thermodynamically unfavourable reactions. 23,24 The EMR overcomes disadvantages of batch stirred tank reactors, 25 -27 consumes low energy and is easy to scale-up.…”

Section: Introductionmentioning

confidence: 99%

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Enzymatic membrane reactors: the determining factors in two separate phase operations

Agustian¹,

Kamaruddin²,

Bhatia³

2011

J of Chemical Tech & Biotech

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A two separate phase-enzymatic membrane reactor is an attractive process since it has a large interfacial area and exchange surfaces, simultaneous reaction and separation and other benefits. Many factors influence its successful operation, and these include characteristics of the enzyme, membrane, circulating fluids and reactor operations. Although the operating conditions are the main factor, other factors must be considered before, during or after its application. At the initial stage of reactor development, the solubility of substrates and products, type of operation, membrane material and size, enzyme preparation and loading procedure, and cleanliness of the recirculated fluids should be specified. The immobilization site, reactor arrangement, dissolved or no-solvent operation, classic or emulsion operation and immobilized or suspended enzyme(s) are determined later. Some factors still need further studies. Utilization of the technology is described for use from multigram-to plant-scale capacity to process racemic and achiral compounds. The racemates were resolved primarily by kinetic resolution, but dynamic kinetic resolution has been exploited. The technology focused on hydrolytic reactions, but esterification processes were also exploited.

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Membrane Reactors

Drioli

Fontananova

2010

Ullmann's Encyclopedia of Industrial Chemistry

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Membrane reactors (MRs) are systems in which a membrane separation process is combined with a chemical (catalytic) reaction. Because there are different ways to combine a catalyst with a membrane in order to have a synergic effect on the entire process, there are numerous possible categorizations of these systems. Some useful classifications are presented to highlight the advantages and still‐existing limitations of MRs in comparison with traditional reactors. Classification can be based on the role of the membrane in the catalytic process (catalytically active or providing only a separation function), the type of transport through the membrane (extractor‐, distributor‐, and contactor‐type MRs), the natures of the membrane material (organic or inorganic) and catalyst (artificial or biological). Applications of MRs in high‐temperature reactions using inorganic membranes and in low‐temperature MRs using polymer membranes are presented, as well as large‐scale applications in membrane bioreactors for wastewater treatment. 1. Introduction 2. Extractor‐, Distributor‐, and Contactor‐Type Membrane Reactors 3. Organic and Inorganic Membrane Reactors 4. Biocatalytic Membrane Reactors 5. Catalytically Active and Catalytically Inert Membranes

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An innovative approach to improve the performance of a two separate phase enzyme membrane reactor by immobilizing lipase in presence of emulsion

Cited by 40 publications

References 13 publications

Molecular Recognition‐Driven Membrane Processes

Molecular Recognition‐Driven Membrane Processes

Enzymatic membrane reactors: the determining factors in two separate phase operations

Membrane Reactors

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