An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes

Rosario, Wilfredo; D’Alessio, David

doi:10.2337/db15-0436

Cited by 5 publications

(5 citation statements)

References 23 publications

(27 reference statements)

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“…This supports a cascade of events initiated by GLP-1RA, ultimately providing multifactorial (involving both intrinsic healing as well as supporting a healthy microbiome [12]) mucosal protection and healing.…”

Section: Introductionsupporting

confidence: 59%

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A Novel Use of Liraglutide: Induction of Partial Remission in Ulcerative Colitis and Ankylosing Spondylitis

Jeffrey¹

2019

Clin Med Rev Case Rep

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Ulcerative colitis and ankylosing spondylitis treatment options are limited to a few classes of medications at this time. Those options provide improvement for some patients, but leaves many with ongoing, unremitting symptoms. We report a case of ulcerative colitis (UC) with comorbid ankylosing spondylitis (AS), in which administration of a daily subcutaneous liraglutide, an exogenous Glucagon-like Peptide-1 receptor agonist (GLP-1RA), led to symptomatic remission of UC and significant improvement in AS symptoms.

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Section: Introductionsupporting

confidence: 59%

“…Exogenous GLP-1RA have the primary benefit of a wild-type mice and reduced edema with a more normal gene expression pattern in mice with colitis" [12].…”

Section: Introductionmentioning

confidence: 99%

A Novel Use of Liraglutide: Induction of Partial Remission in Ulcerative Colitis and Ankylosing Spondylitis

Jeffrey¹

2019

Clin Med Rev Case Rep

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“…Exogenous GLP-1RA have the primary benefit of a wild-type mice and reduced edema with a more normal gene expression pattern in mice with colitis" [12]. This supports a cascade of events initiated by GLP-1RA, ultimately providing multifactorial (involving both intrinsic healing as well as supporting a healthy microbiome [12]) mucosal protection and healing.…”

Section: Introductionmentioning

confidence: 81%

Untitled

2019

Clin Med Rev Case Rep

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“…The lamina propria is composed of a variety of structural cells and immune cells, nerve endings, and vascular vessels. We observed that several cells of the lamina propria expressed GLP1R: neurons [ 30 ], blood vessels [ 31 ], intraepithelial lymphocytes [ 32 ], and smooth muscular cells [ 33 ]. However, in the present paper we did not further characterize their presence in the samples we analyzed.…”

Section: Discussionmentioning

confidence: 99%

GLP1 Exerts Paracrine Activity in the Intestinal Lumen of Human Colon

Grau-Bové

González-Quilen

Cantini

et al. 2022

IJMS

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GLP1 produced in the upper part of the gut is released after food intake and acts by activating insulin secretion, but the role of GLP1 in the colon, where it is predominantly produced, remains unknown. Here we characterized the apical versus basolateral secretion of GLP1 and PYY and the paracrine mechanisms of action of these enterohormones in the human colon. We stimulated human colon tissue in different ex vivo models with meat peptone and we used immunofluorescence to study the presence of canonical and non-canonical receptors of GLP1. We found that PYY and GLP1 are secreted mainly at the gut lumen in unstimulated and stimulated conditions. We detected DPP4 activity and found that GLP1R and GCGR are widely expressed in the human colon epithelium. Unlike GLP1R, GCGR is not expressed in the lamina propria, but it is located in the crypts of Lieberkühn. We detected GLP1R expression in human colon cell culture models. We show that the apical secretion of PYY and GLP1 occurs in humans, and we provide evidence that GLP1 has a potential direct paracrine function through the expression of its receptors in the colon epithelium, opening new therapeutic perspectives in the use of enterohormones analogues in metabolic pathologies.

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An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes

Cited by 5 publications

References 23 publications

A Novel Use of Liraglutide: Induction of Partial Remission in Ulcerative Colitis and Ankylosing Spondylitis

A Novel Use of Liraglutide: Induction of Partial Remission in Ulcerative Colitis and Ankylosing Spondylitis

Untitled

GLP1 Exerts Paracrine Activity in the Intestinal Lumen of Human Colon

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