An Injectable System for Local and Sustained Release of Antimicrobial Agents in the Periodontal Pocket

Morelli, Laura; Cappelluti, Martino Alfredo; Ricotti, Leonardo; Lenardi, Cristina; Gerges, Irini

doi:10.1002/mabi.201700103

Cited by 14 publications

(16 citation statements)

References 41 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…176 In recent research studies, the micrometer-sized β-CD-based hydrogel (bCD-Jef-MPs) system also achieved sustained release of chlorhexidine digluconate, thus treating periodontitis lesions became effective. 177 The prolonged release has made it possible to decrease its dosage. Therefore, its side effects were reduced.…”

mentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

302

230

View full text Add to dashboard Cite

The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

show abstract

mentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

302

230

View full text Add to dashboard Cite

show abstract

“…Nowadays, several intra-pocket drug delivery systems, such as solutions, gels, fibers, films and inserts, have been investigated and, sometimes, proposed on the market. Nevertheless, such systems show some limitations resulting in the reduced treatment efficacy and/or low patient compliance; for example, in the case of solutions, the drug at the site of infection/inflammation has poor retention, and the drug release rate is not controlled, while, in the case of inserts, there is pain caused by their insertion in the sub-gingival areas [ 79 , 80 ].…”

Section: Buccal Routementioning

confidence: 99%

“…For these reasons, in situ gelling systems, in particular thermo-sensitive ones, have been proposed as valid candidates for local intra-pocket drug delivery. Being fluids before and during administration, they can be easily injected by means of a periodontal syringe, allowing the formulation to get access to the entire pocket; once administered, they undergo sol–gel phase transition resulting in soft but robust gels that are able to prolong the release rate of the drug, residing at the site of action for a desirable period of time ( Figure 4 ) [ 79 , 81 ].…”

Section: Buccal Routementioning

confidence: 99%

“…Afterward, Morelli et al [ 79 ] developed a thermo-sensitive system, based on poloxamer, containing β-cyclodextrin-Jeffamine microparticles for the sustained release of chlorhexidine (CHX), while Beg and co-workers [ 80 ] designed a novel poloxamer-based gelling formulation in which PLGA nanoparticles loaded with moxifloxacin (MOX-NPs) were dispersed. In the latter work, in vivo studies revealed that the system developed was able to reside at the periodontal site for a prolonged period of time, guaranteeing an extended MOX release.…”

Section: Buccal Routementioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in the Development of In Situ Gelling Drug Delivery Systems for Non-Parenteral Administration Routes

et al. 2020

View full text Add to dashboard Cite

In situ gelling drug delivery systems have gained enormous attention over the last decade. They are in a sol-state before administration, and they are capable of forming gels in response to different endogenous stimuli, such as temperature increase, pH change and the presence of ions. Such systems can be administered through different routes, to achieve local or systemic drug delivery and can also be successfully used as vehicles for drug-loaded nano- and microparticles. Natural, synthetic and/or semi-synthetic polymers with in situ gelling behavior can be used alone, or in combination, for the preparation of such systems; the association with mucoadhesive polymers is highly desirable in order to further prolong the residence time at the site of action/absorption. In situ gelling systems include also solid polymeric formulations, generally obtained by freeze-drying, which, after contact with biological fluids, undergo a fast hydration with the formation of a gel able to release the drug loaded in a controlled manner. This review provides an overview of the in situ gelling drug delivery systems developed in the last 10 years for non-parenteral administration routes, such as ocular, nasal, buccal, gastrointestinal, vaginal and intravesical ones, with a special focus on formulation composition, polymer gelation mechanism and in vitro release studies.

show abstract

“…O ácido polilático (PLA), ácido poliglicólico (PGA), poli (ácido lático-co-ácido glicólico) (PLGA) e a poli (ɛ-caprolactona) (PCL) são alguns exemplos de polímeros que vêm sendo utilizados na confecção de nanofibras pelo processo de eletrofiação, entretanto, seu uso na medicina começou há muitos anos, por exemplo, em suturas absorvíveis e em sistemas de osteossíntese (Huang et al, 2003;Felice et al, 2014; Al-Moraissi; Ellis, 2015; Prakasam et al, 2017). Na odontologia, os polímeros biodegradáveis têm destaque na área de periodontia, principalmente na liberação de antibióticos e antissépticos tais como: tetraciclina (Shahi et al, 2017), metronidazol (Varshosaz et al, 2002) e clorexidina (Yue et al, 2004;Morelli et al, 2017). Na regeneração tecidual eles também desempenham um papel importante na repopulação celular guiada pela formação de arcabouços e liberação de fatores de crescimento.…”

Section: Polímeros Reabsorvíveisunclassified

Nanofibras poliméricas carregadas com oxitetraciclina para tratamento de alveolite seca: estudo em ratos

Viera¹

View full text Add to dashboard Cite

Dry socket is one of the most common and symptomatic postoperative complications in tooth extraction, however, to date, it does not have an established treatment protocol. Oxytetracycline (OTC) is a broad-spectrum antibiotic, employed in the treatment of multiple infections. Nevertheless, in the last few years, first-generation tetracyclines such as OTC, have been avoided due to the development of resistant microorganisms. Fortunately, in recent years there has been a contrary trend thanks to control measures in the use of antibiotics. Controlled release systems can prevent the development of bacterial resistance and decrease the risk of adverse effects. This study aimed to prepare a polymeric nanofiber of polycaprolactone and oxytetracycline (PCL/OTC), and to evaluate its physical and biological properties in vitro and in vivo, aiming its use in the treatment of dry socket at the future. The OTC-charged polymeric nanofibers were prepared by electrospinning, and characterized by scanning electron microscopy (SEM) and drug release profile evaluation. The antibacterial activity of the nanofiber over a mixed biofilm containing Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Eikenella corrodens, Streptococcus sanguis, and Aggregatibacter actinomycetemcomitans was analyzed by counting the viable colony-forming units after 1, 4, 24, 30 and 48 h of contact. The alveolar repair process induced by the PCL/OTC nanofiber was evaluated histomorphologically and histomorphometrically after the treatment of dry socket in rat molars, and compared to the treatment with plain PCL nanofibers and Alvogyl TM , 7, 14 and 21 days after extraction. Finally, the identification and counting of osteoclasts were performed through the tartrate resistant acid phosphatase (TRAP) staining, at the same evaluation time points. PCL/OTC nanofibers presented random orientation in layers and multiform morphology. The release profile of the PCL/OTC system showed a burst effect within the first 8 hours, followed by a prolonged slow release period. The PCL/OTC nanofiber at a concentration of 132 μg OTC/mL reduced more than 50% of the biofilm colonies in the first few hours of release, followed by a maintenance period in which the percentage of bacterial colonies remained low. The PCL/OTC group presented the highest percentage of connective tissue on the 7 th day (p<0.05), and of newly formed bone on the 14 th and 21 st days (p<0.05) after dental extraction, compared to the other groups. The treatment of dry socket with the PCL/OTC fiber allowed almost complete tissue regeneration up to the 21 st day, and the chronology of tissue regeneration with this material was faster than with the plain PCL fiber, and the latter was more rapid than the positive control Alvogyl TM. The PCL/OTC group presented a lower amount (p<0.05) of osteoclasts per area than the other two groups in the three experimental periods. The prolonged release profile of OTC and the relevant biological properties presented by the PCL/OTC nanofibers suggest that th...

show abstract

An Injectable System for Local and Sustained Release of Antimicrobial Agents in the Periodontal Pocket

Cited by 14 publications

References 41 publications

Antimicrobial hydrogels: promising materials for medical application

Antimicrobial hydrogels: promising materials for medical application

Recent Advances in the Development of In Situ Gelling Drug Delivery Systems for Non-Parenteral Administration Routes

Nanofibras poliméricas carregadas com oxitetraciclina para tratamento de alveolite seca: estudo em ratos

Contact Info

Product

Resources

About