An Injectable silk-based hydrogel as a novel biomineralization seedbed for critical-sized bone defect regeneration

Zhu, Yuhui; Gu, Hao; Yang, Jiawei; Li, Anshuo; Hou, Lingli; Zhou, Mingliang; Jiang, Xinquan

doi:10.1016/j.bioactmat.2024.01.024

Cited by 5 publications

(1 citation statement)

References 50 publications

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“… [ 167 ] Silk protein-based Amorphous calcium phosphate Critical-sized bone defect Oxidized silk fibroin. [ 168 ] Polysaccharides hydrogels Hyaluronic acid-based Stromal cell-derived factor-1 alpha Fracture Two chemically modified hyaluronic acid blends. [ 169 ] Metal-polyphenol nanoparticles Rotator cuff tear Dopamine modification to enhance adhesion and plasticity.…”

Section: Advantages Of Hydrogel-exosome Systems For Tissue Engineeringmentioning

confidence: 99%

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Fan,

Pi,

Zou

et al. 2024

Bioactive Materials

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Section: Advantages Of Hydrogel-exosome Systems For Tissue Engineeringmentioning

confidence: 99%

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Fan,

Pi,

Zou

et al. 2024

Bioactive Materials

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Hydrogel Applications in the Diagnosis and Treatment of Glioblastoma

Zhang,

Zhong,

Younis

et al. 2024

ACS Appl. Mater. Interfaces

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Glioblastoma multiforme (GBM), a common malignant neurological tumor, has boundaries indistinguishable from those of normal tissue, making complete surgical removal ineffective. The blood-brain barrier (BBB) further impedes the efficacy of radiotherapy and chemotherapy, leading to suboptimal treatment outcomes and a heightened probability of recurrence. Hydrogels offer multiple advantages for GBM diagnosis and treatment, including overcoming the BBB for improved drug delivery, controlled drug release for long-term efficacy, and enhanced relaxation properties of magnetic resonance imaging (MRI) contrast agents. Hydrogels, with their excellent biocompatibility and customizability, can mimic the in vivo microenvironment, support tumor cell culture, enable drug screening, and facilitate the study of tumor invasion and metastasis. This paper reviews the classification of hydrogels and recent research for the diagnosis and treatment of GBM, including their applications as cell culture platforms and drugs including imaging contrast agents carriers. The mechanisms of drug release from hydrogels and methods to monitor the activity of hydrogel-loaded drugs are also discussed. This review is intended to facilitate a more comprehensive understanding of the current state of GBM research. It offers insights into the design of integrated hydrogel-based GBM diagnosis and treatment with the objective of achieving the desired therapeutic effect and improving the prognosis of GBM.

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Biological Functions of Macromolecular Protein Hydrogels in Constructing Osteogenic Microenvironment

Wang,

Lv,

Ren

et al. 2024

ACS Biomater. Sci. Eng.

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Irreversible bone defects resulting from trauma, infection, and degenerative illnesses have emerged as a significant health concern. Structurally and functionally controllable hydrogels made by bone tissue engineering (BTE) have become promising biomaterials. Natural proteins are able to establish connections with autologous proteins through unique biologically active regions. Hydrogels based on proteins can simulate the bone microenvironment and regulate the biological behavior of stem cells in the tissue niche, making them candidates for research related to bone regeneration. This article reviews the biological functions of various natural macromolecular proteins (such as collagen, gelatin, fibrin, and silk fibroin) and highlights their special advantages as hydrogels. Then the latest research trends on cross-linking modified macromolecular protein hydrogels with improved mechanical properties and composite hydrogels loaded with exogenous micromolecular proteins have been discussed. Finally, the applications of protein hydrogels, such as 3D printed hydrogels, microspheres, and injectable hydrogels, were introduced, aiming to provide a reference for the repair of clinical bone defects.

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An Injectable silk-based hydrogel as a novel biomineralization seedbed for critical-sized bone defect regeneration

Cited by 5 publications

References 50 publications

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Hydrogel Applications in the Diagnosis and Treatment of Glioblastoma

Biological Functions of Macromolecular Protein Hydrogels in Constructing Osteogenic Microenvironment

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