An injectable refrigerated hydrogel for inducing local hypothermia and neuroprotection against traumatic brain injury in mice
Yuhan Han,
Zhengzhong Han,
Xuyang Huang
et al.
Abstract:Background
Hypothermia is a promising therapy for traumatic brain injury (TBI) in the clinic. However, the neuroprotective outcomes of hypothermia-treated TBI patients in clinical studies are inconsistent due to several severe side effects. Here, an injectable refrigerated hydrogel was designed to deliver 3-iodothyronamine (T1AM) to achieve a longer period of local hypothermia for TBI treatment. Hydrogel has four advantages: (1) It can be injected into injured sites after TBI, where it forms a … Show more
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