An injectable poly(caprolactone trifumarate-gelatin microparticles) (PCLTF-GMPs) scaffold for irregular bone defects: Physical and mechanical characteristics

Al-Namnam, Nisreen Mohammed; Kutty, Muralithran G.; Chai, Wen Lin; Ha, Kien Oon; Hwi, Kim Kah; Siar, Chong Huat; Ngeow, Wei Cheong

doi:10.1016/j.msec.2016.11.086

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…A novel material named poly(caprolactone trifumarate)-gelatin microparticles (PCLTF-GMPS) was created using different ratios of PCL, Poly(propylene fumarate) (PPF) and gelatin. The biocompatibility and osteoconductivity of the created scaffold was demonstrated through the bone deposition and complete healing in critical size cranial defects in a rabbits [ 118 ]. Additionally, it revealed that the scaffold’s mechanical strength can be increased by boosting the ratio of PCL content in a composite.…”

Section: Polymer-based Bone Substitutesmentioning

confidence: 99%

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

et al. 2021

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Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and biological performance of different synthetic materials for bone, periodontal, and dental tissue regeneration. They include calcium phosphate cements and their variants β-tricalcium phosphate (β-TCP) ceramics and biphasic calcium phosphates (hydroxyapatite (HA) and β-TCP ceramics), calcium sulfate, bioactive glasses and polymer-based bone substitutes which include variants of polycaprolactone. In summary, the search for synthetic bone substitutes remains elusive with calcium compounds providing the best synthetic substitute. The combination of calcium sulphate and β-TCP provides improved handling of the materials, dispensing with the need for a traditional membrane in guided bone regeneration. Evidence is supportive of improved angiogenesis at the recipient sites. One such product, (EthOss® Regeneration, Silesden UK) has won numerous awards internationally as a commercial success. Bioglasses and polymers, which have been used as medical devices, are still in the experimental stage for dental application. Polycaprolactone-TCP, one of the products in this category is currently undergoing further randomized clinical trials as a 3D socket preservation filler. These aforementioned products may have vast potential for substituting human/animal-based bone grafts.

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Section: Polymer-based Bone Substitutesmentioning

confidence: 99%

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

et al. 2021

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“…An emulsion templating method has been proposed as a new manufacturing technique to promote cell migration and growth 137 . Finally, the biological properties of PCL have been continuously developed by implementing gelatin microparticles, 138 β‐tricalcium phosphate, 139 or magnesium oxide 140 . Data on utilization of PCL for GBR, especially information on membrane exposure and bacterial contamination, are limited 141 …”

Section: Resorbable Membranesmentioning

confidence: 99%

Membrane barriers for guided bone regeneration: An overview of available biomaterials

Mizraji,

Davidzohn,

Gursoy

et al. 2023

Periodontology 2000

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Dental implants revolutionized the treatment options for restoring form, function, and esthetics when one or more teeth are missing. At sites of insufficient bone, guided bone regeneration (GBR) is performed either prior to or in conjunction with implant placement to achieve a three‐dimensional prosthetic‐driven implant position. To date, GBR is well documented, widely used, and constitutes a predictable and successful approach for lateral and vertical bone augmentation of atrophic ridges. Evidence suggests that the use of barrier membranes maintains the major biological principles of GBR. Since the material used to construct barrier membranes ultimately dictates its characteristics and its ability to maintain the biological principles of GBR, several materials have been used over time. This review, summarizes the evolution of barrier membranes, focusing on the characteristics, advantages, and disadvantages of available occlusive barrier membranes and presents results of updated meta‐analyses focusing on the effects of these membranes on the overall outcome.

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“…Scaffolds are porous and temporary three-dimensional supports with adequate biophysical and biochemical conditions, both for cell propagation and to remain integrated to the host tissue, without risk of rejection, with synergistic action in the acceleration of angiogenesis, favoring the differentiation of mesenchymal cells. These properties have aroused the interest of several researchers (Al-Namnam et al, 2017;Heras et al, 2019;Sharipova, Gotman, Psakhie, & Gutmanas, 2019;Xu et al, 2015).Therefore, several studies have been done with scaffolds for application as biomaterial for bone repair, among these: calcium phosphate scaffolds (Batista, 2016;Lett, Sagadevan, Prabhakar, & Latha, 2019); hydroxyapatite and magnetite scaffolds (Chaves, 2015;Xu et al, 2015); bioscaffold hydroxyapatite doped with MgFe2O4 (John, Janeta, & Szafert, 2017); scaffold with strontium/hydroxyapatite and chitosan ; chitosan scaffold and hydroxyapatite (R. S. Almeida et al, 2019;Anamarua et al, 2016;Atak et al, 2017;Dantas, 2016;. These and other researches have proven the potential of scaffolds' properties in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Chitosan and hydroxyapatite scaffolds with amoxicillin for bone repair

Ponciano

Costa

Barbosa

et al. 2021

RSD

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The bone repair process, among other physiological mechanisms, occurs in a harmonious manner throughout the body. However, the presence of some deleterious factors such as surgery, trauma or pathology, can interfere with the physiology of bone remodeling. It´s Known that the synergistic antimicrobial action between drugs and biomaterials can help and favor osteogenesis after grafting surgery. Therefore, this study aims to develop chitosan / hydroxyapatite scaffolds with amoxicillin for bone repair in the oral cavity. For this, raw materials were selected and characterized and scaffolds were made by the processes of solubilization, dispersion and lyophilization. The characterizations were made by optical microscopy, scanning electron microscopy, eenergy dispersive spectrometer, swelling potential, degradation analysis, apparent porosity test and in vitro cell cytotoxicity. The scaffolds produced in this research showed to have not only adequate physical characteristics but also chemical and biological ones. It was as well as detected a reproducible methodology that resulted in a biomaterial with morphology that provided a high degree of swelling, porosity, satisfactory degradation and the presence of amoxicillin which was confirmed by the eenergy dispersive spectrometer. Nevertheless, the scaffolds with 30% hydroxyapatite showed the best results for in vitro cell viability. So, it is possible to conclude that the scaffolds produced show successful characteristics for bone repair in the oral cavity.

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An injectable poly(caprolactone trifumarate-gelatin microparticles) (PCLTF-GMPs) scaffold for irregular bone defects: Physical and mechanical characteristics

Cited by 3 publications

References 23 publications

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Membrane barriers for guided bone regeneration: An overview of available biomaterials

Chitosan and hydroxyapatite scaffolds with amoxicillin for bone repair

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