An injectable hydrogel dotted with dexamethasone acetate-encapsulated reactive oxygen species-scavenging micelles for combinatorial therapy of osteoarthritis

Zhou, Tong; Xiong, Hao; Wang, Shuqin; Zhang, Haolan; Zheng, Weiwei; Gou, Zhongru; Fan, Cunyi; Gao, Changyou

doi:10.1016/j.mtnano.2021.100164

Cited by 22 publications

(17 citation statements)

References 49 publications

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“…Dressings with antioxidant activity can regulate the content of reactive oxygen species around the wound to promote wound healing. , Its antioxidant activity was evaluated by testing the scavenging efficiency of the QCS/OD/TOB/PPY@PDA hydrogel for 1, 1-diphenyl-2-picrylhydrazyl (DPPH). The results in Figure a showed that the QCS/OD hydrogel has a scavenging ratio of 48% for DPPH, which is because of the combined action of the free aldehyde groups and QCS of the QCS/OD hydrogel. ,, After the incorporation of TOB into the hydrogel, the scavenging ratio of the QCS/OD/TOB hydrogel for DPPH increased to 85%. In addition, the antioxidant efficiency of the hydrogels was further enhanced after incorporating PPY@PDA and increased with the increase of PPY@PDA content, among which the DPPH scavenging ratio of the QCS/OD/TOB/PPY@PDA9 hydrogel and QCS/OD/TOB/PPY@PDA12 hydrogel is over 90%.…”

Section: Resultsmentioning

confidence: 97%

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

et al. 2022

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Burns are a common health problem worldwide and are highly susceptible to bacterial infections that are difficult to handle with ordinary wound dressings. Therefore, burn wound repair is extremely challenging in clinical practice. Herein, a series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) with good electrical conductivity and antioxidant activity were prepared on the basis of quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), and polydopaminecoated polypyrrole nanowires (PPY@PDA NWs). These Schiff base crosslinks between the aminoglycoside antibiotic TOB and OD enable TOB to be slowly released and responsive to pH. Interestingly, the acidic substances during the bacteria growth process can induce the on-demand release of TOB, avoiding the abuse of antibiotics. The antibacterial results showed that the QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations of Pseudomonas aeruginosa (PA), Staphylococcus aureus, and Escherichia coli in a short time and showed a bactericidal effect for up to 11 days in an agar plate diffusion experiment, while showing good in vivo antibacterial activity. Excellent and long-lasting antibacterial properties make it suitable for severely infected wounds. Furthermore, the incorporation of PPY@PDA endowed the hydrogel with near-infrared (NIR) irradiation assisted bactericidal activity of drug-resistant bacteria, conductivity, and antioxidant activity. Most importantly, in the PA-infected burn wound model, the QCS/OD/TOB/PPY@PDA9 hydrogel more effectively controlled wound inflammation levels and promoted collagen deposition, vascular generation, and earlier wound closure compared to Tegaderm dressings. Therefore, the TOB smart release hydrogels with on-demand delivery are extremely advantageous for bacterial-infected burn wound healing.

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Section: Resultsmentioning

confidence: 97%

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

et al. 2022

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“…In addition to the selection and modification of the hydrogel network matrix, some researchers added new systems to the hydrogel network. T. Zhou et al [ 71 ] used poly(ethylene glycol)-b-polythioketal-b-poly(ethylene glycol) (PEG-PTK-PEG) micelles as the carrier of dexamethasone (DA), combined with hydrazine grafted hyaluronic acid (HA-ADH) and aldehyde modified dextran (Dex-ALH) to achieve slow linear release of DA, reduce oxidative stress, and inhibit the occurrence of osteoarthritis ( Figure 4 ). P. Wang et al [ 72 ] added microcrystalline cellulose (MCC) to functional polyglutamic acid (γ-PGA) and sodium alginate (SA).…”

Section: Application Of Self-healing Hydrogels In Tissue Engineeringmentioning

confidence: 99%

“…The hydrogel is swollen and/or degraded in OA joint, allowing the easier reaction between the PDM and ROS to release DA. They synergistically reduce the ROS concentration, upregulate the M2 polarization, downregulate the key inflammatory cytokines, and thereby achieve better therapy of OA in vivo [ 71 ]. Reproduced with permission from Zhou, T, Mater.…”

Section: Figurementioning

confidence: 99%

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Liang

Yuan

et al. 2022

Polymers

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Self-healing hydrogels and traditional hydrogels both have three-dimensional polymeric networks that are capable of absorbing and retaining a large amount of water. Self-healing hydrogels can heal and restore damage automatically, and they can avoid premature failure of hydrogels caused by mechanical damage after implantation. The formation mechanism of self-healing hydrogels and the factors that hydrogels can load are various. Researchers can design hydrogels to meet the needs of different tissues through the diversity of hydrogels Therefore, it is necessary to summarize different self-healing mechanisms and different factors to achieve different functions. Here, we briefly reviewed the hydrogels designed by researchers in recent years according to the self-healing mechanism of water coagulation. Then, the factors for different functions of self-healing hydrogels in different tissues were statistically analyzed. We hope our work can provide effective support for researchers in the design process of self-healing hydrogel.

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“…Several research studies have thus focused on enhancing the retention of HA in the synovial fluid by delivering HA as a component of a composite hydrogel [ 45 , 46 , 47 ]. The fabrication of such hydrogels most often involves modifying the backbone of HA with a reactive group, such as tyramine [ 46 ], vinyl sulfone [ 47 ], and hydrazide [ 48 ], and combining it with a second polymeric chain that will undergo either a non-covalent interaction or covalent crosslinking with the modified HA chain. The second chain could be a long polymer or biomacromolecule, or a short crosslinker that enables HA chains to form a tight network.…”

Section: Ha Hydrogels For Joint Lubricationmentioning

confidence: 99%

Engineering Hyaluronic Acid for the Development of New Treatment Strategies for Osteoarthritis

Kim

Guilak

2022

IJMS

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Osteoarthritis (OA) is a degenerative joint disease that is characterized by inflammation of the joints, degradation of cartilage, and the remodeling of other joint tissues. Due to the absence of disease-modifying drugs for OA, current clinical treatment options are often only effective at slowing down disease progression and focus mainly on pain management. The field of tissue engineering has therefore been focusing on developing strategies that could be used not only to alleviate symptoms of OA but also to regenerate the damaged tissue. Hyaluronic acid (HA), an integral component of both the synovial fluid and articular cartilage, has gained widespread usage in developing hydrogels that deliver cells and biomolecules to the OA joint thanks to its biocompatibility and ability to support cell growth and the chondrogenic differentiation of encapsulated stem cells, providing binding sites for growth factors. Tissue-engineering strategies have further attempted to improve the role of HA as an OA therapeutic by developing diverse modified HA delivery platforms for enhanced joint retention and controlled drug release. This review summarizes recent advances in developing HA-based hydrogels for OA treatment and provides additional insights into how HA-based therapeutics could be further improved to maximize their potential as a viable treatment option for OA.

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An injectable hydrogel dotted with dexamethasone acetate-encapsulated reactive oxygen species-scavenging micelles for combinatorial therapy of osteoarthritis

Cited by 22 publications

References 49 publications

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Engineering Hyaluronic Acid for the Development of New Treatment Strategies for Osteoarthritis

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