An Initial Appraisal of the Clinical Significance of Roseomonas Species Associated with Human Infections

Struthers, Mary; Wong, Jane D.; Janda, J. Michael

doi:10.1093/clinids/23.4.729

Cited by 59 publications

(82 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Roseomonas spp. are also potential pathogens; most strains are associated with septicemia and other human infections (Struthers et al 1996). It is also worth mentioning that novel bacteria were discovered through pyrosequencing in the present study.…”

Section: Discussionmentioning

confidence: 58%

Bacterial communities of Beijing surface waters as revealed by 454 pyrosequencing of the 16S rRNA gene

Wei

Wang

Liu

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

As a better understanding of Beijing surface water ecosystems can provide clues for environmental management and public health, here, we report a study of the bacterial communities of five Beijing surface waters conducted using 454 pyrosequencing of 16S ribosomal RNA (rRNA) genes. We expected to observe a core bacterial community among the surface waters and differences in bacterial community abundance over the different locations of sampling. In this study, we obtained a total of 60,810 trimmed reads from the five samples after the removal of unqualified reads. Bacterial sequences from the five samples were classified into taxonomic classes using the default settings of the mothur platform. Our results provided insight into the bacterial community composition of surface waters and revealed that there was a core microbial community in the microbial populations of surface samples at different geographic locations, with 13 phyla and 40 genera in common. Our findings also revealed the differences in bacterial communities among five surface water samples obtained at different locations.

show abstract

Section: Discussionmentioning

confidence: 58%

Bacterial communities of Beijing surface waters as revealed by 454 pyrosequencing of the 16S rRNA gene

Wei

Wang

Liu

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…When the organism is cultured from nonsterile body sites, it can be difficult to determine its clinical significance. In a retrospective review of Roseomonas infections, up to 40% of the isolates were not associated with disease (7). Similarly, a recent review reported that 25% of clinical isolates were not considered significant pathogens (8).…”

mentioning

confidence: 99%

“…Members of the genus are widely distributed in the environment in the air, water, and soil, but the natural reservoir of the microorganism is currently unknown (6). Roseomonas species generally have low virulence, although some species have been reported to cause serious infections in immunocompromised patients (7). When the organism is cultured from nonsterile body sites, it can be difficult to determine its clinical significance.…”

mentioning

confidence: 99%

Roseomonas Spinal Epidural Abscess Complicating Instrumented Posterior Lumbar Interbody Fusion

et al. 2013

View full text Add to dashboard Cite

The first case of a spinal epidural abscess caused by Roseomonas mucosa following instrumented posterior lumbar fusion is presented. Although rare, because of its highly resistant profile, Roseomonas species should be included in the differential diagnosis of epidural abscesses in both immunocompromised and immunocompetent hosts. CASE REPORTA 54-year-old woman was admitted to the Emergency Department of the University Hospital in Crete, Greece, with complaints of purulent drainage, mild pain, and redness at the site of incision. The patient had been operated on 15 days previously due to spinal stenosis. The type of surgery performed was decompressive lumbar laminectomy followed by instrumented posterior spinal fusion.Physical examination revealed a large, deep-wound dehiscence with exudates, erythema, pain, induration, edema, and cellulitis.The general condition of the patient was good. She was feverless, and results of the laboratory exams were the following: a white blood cell (WBC) count of 6,000/mm 3 , an erythrocyte sedimentation rate (ESR) of 97 mm/h, and a C-reactive protein (CRP) level of 4.82 mg/dl (normal range, 0.08 to 08 mg/dl). The patient underwent deep surgical debridement and was placed on empirical intravenous (i.v.) vancomycin and oral rifampin for a total of 24 days.Although the wound healed and the infection resolved, the results of the blood tests worsened. The inflammatory markers increased: the ESR was 113 mm/h, and the CRP level was 13.7 mg/dl. The patient's temperature increased to 39°C, and she complained of back pain. The magnetic resonance image (MRI) scan demonstrated the presence of a large epidural abscess anterior to the L2 and L3 vertebrae, compressing the thecal sac (Fig. 1). There was no evidence of osteomyelitic involvement. The patient underwent drainage of her epidural abscess, and cultures of the pus grew pink-pigmented colonies on Columbia and chocolate agar plates after 48 h of incubation at 36°C. The isolate was catalase and urease positive and weakly oxidase positive, and it assimilated arabinose, malate, citrate, and glucose. In Gram-stained smears, the organisms appeared as Gram-negative, plump coccobacilli in pairs. The isolate was identified as Roseomonas gilardii by using the Vitek 2 automated system (bioMérieux, Marcy L'Etoile, France). Sequencing analysis of 1,455 nucleotides of the 16S rRNA genes (a nearly complete sequence) was performed, and the derived sequence was queried against GenBank. The results showed that our strain exhibited the highest similarity with the Roseomonas mucosa 16S rRNA gene sequences. Multiple alignments were performed using the ClustalW program, and a distance tree was derived using the neighbor-joining method (1) offered in the MEGA 5 software package (2). Results indicated that our strain (Roseomonas sp. strain SM14032013) clustered together with Roseomonas mucosa, Roseomonas massiliae, and Roseomonas terpenica species, while Roseomonas gilardii strains formed a distinct group (Fig. 2).The agar gradient diffusion (Etest) method was e...

show abstract

“…Roseomonas strains have been most commonly isolated from middle-aged women with one of several underlying conditions, including cancer and diabetes. Previous studies reported that in 88% of Roseomonas case reports, the organism was isolated from the blood, respiratory problems occurred in 16%, wound infection in 8%, peritonitis in 4%, enteritis in 8%, kidney transplant infection in 4% and eye infection in 4% (3,6,(9)(10).…”

mentioning

confidence: 99%

A Case of Pericarditis Due to Roseomonas Gilardii in a Patient with Angiosarcoma of the Pericardium

2013

View full text Add to dashboard Cite

Roseomonas gilardii is a Gram-negative slow growing coccobacillus that has been recognized as an opportunistic pathogen which can lead to infections, especially in immunocompromised and chronically ill patients. The organism is generally susceptible to carbapenems and aminoglycosides, but resistant to most of the cephalosporins. We report what we believe is the first case of a 72-year-old oncologic woman who developed a pericarditis caused by R. gilardii in Italy.Roseomonas gilardii is an aerobic Gram-negative coccobacillus, oxidative, non-fermentative, slow growing and pink-pigmented (1-2). The genus Roseomonas contains four named species (R. gilardii, R. mucosa, R. cervicalis and R. fauriae) and three unnamed genomospecies 4, 5 and 6 (3-4). The natural reservoir for Roseomonas infection is unknown (5). Although it has been isolated from water supplies (3, 6), it may also exist as a commensal in humans. R. gilardii is most frequently related to human infections, however human infections due to Roseomonas species are uncommon and the vast majority of reported infections are opportunistic and easy to treat but can cause disseminated infections, particularly in debilitated host (7). Some infection due to Roseomonas spp. have involved bacteraemia in persons with central venous catheters and underlying malignancies or other chronic diseases (8). Roseomonas strains have been most commonly isolated from middle-aged women with one of several underlying conditions, including cancer and diabetes. Previous studies reported that in 88% of Roseomonas case reports, the organism was isolated from the blood, respiratory problems occurred in 16%, wound infection in 8%, peritonitis in 4%, enteritis in 8%, kidney transplant infection in 4% and eye infection in 4% (3, 6, 9-10).A 72-year-old female was admitted to the emergency department for constrictive pericarditis and pericardial effusion of unknown aetiology and proliferative lesion suspected to be cardiac tumour. The patient reports a previous pericarditis in 2012, and loss of appetite and weight in the last six months. Full-body computed tomography (CT) examination demonstrated a marked thickening of the pericardium with solid plaques on the right side and pericardial effusion. Serum tumour marker studies revealed elevated CA125 and neuron specific enolace (NSE), but others, including CA19-9 and carcinoembryonic antigen (CEA) were within normal limits. A port was surgically inserted into the patient and successively a pericardiocentesis and a biopsy of the pericardium were performed. The histological and cytopathological examination by surgical biopsy of the pericardium confirmed the diagnosis of pericardial angiosarcoma.

show abstract

An Initial Appraisal of the Clinical Significance of Roseomonas Species Associated with Human Infections

Cited by 59 publications

References 5 publications

Bacterial communities of Beijing surface waters as revealed by 454 pyrosequencing of the 16S rRNA gene

Bacterial communities of Beijing surface waters as revealed by 454 pyrosequencing of the 16S rRNA gene

Roseomonas Spinal Epidural Abscess Complicating Instrumented Posterior Lumbar Interbody Fusion

A Case of Pericarditis Due to Roseomonas Gilardii in a Patient with Angiosarcoma of the Pericardium

Contact Info

Product

Resources

About