An Inhibitory Effect of Glycyrrhizin on Metabolic Actions of Cortisone

Kumagai, Akira; Nishino, Kazuhiko; Yamamoto, Masahiro; Nanaboshi, Masahisa; Yamamura, Yuichi

doi:10.1507/endocrj1954.13.416

Cited by 14 publications

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References 2 publications

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“…Some tests are relatively simple to carry out, and, for example, the large number of compounds shown to have antibacterial and non-steroid anti-inflammatory activities may reflect the relative ease of testing. Particular com pounds in this mixture have a long history of research; this includes glycyrrhetinic acid which is a potent inhibitor of ll|3-hydroxysteroid dehydrogenase which in the body is responsible for conversion of cortisol to cortisone [24], This compound is found in G. glabrae. Taylor et al…”

Section: Clinical Evidence For the Efficacy Of Zemaphytementioning

confidence: 99%

The Efficacy of Traditional Chinese Herbal Therapy in Atopic Eczema

Latchman¹,

Whittle²,

Rustin

et al. 1994

Int Arch Allergy Immunol

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A traditional Chinese herbal therapy (Zemaphyte®) for the treatment of atopic eczema (AE) is currently being assessed. This review attempts to highlight its success in patients who are recalcitrant to Western forms of treatment and the rationale behind its use. The herbal preparation is a mixture of 10 herbs with some known pharmacological agents and actions. The concept of such a complex mixture in clinical treatment is anathema to Western medicine but acceptable in traditional Chinese medicine. As this formation has been shown to be effective in two double-blind crossover trials, investigative work on components from the mixture must be established in order to find the active constituent(s) and describe their mode of action. This research will also lead to a greater understanding of the complex immunopathology of AE.

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Section: Clinical Evidence For the Efficacy Of Zemaphytementioning

confidence: 99%

The Efficacy of Traditional Chinese Herbal Therapy in Atopic Eczema

Latchman¹,

Whittle²,

Rustin

et al. 1994

Int Arch Allergy Immunol

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“…It has been reported from our laboratory that glycyrrhizin inhibited the following biological actions of cortisone : anti-granulomatous action (Kumagai et al, 1964), suppression of ACTH biosynthesis in the pituitary (Kumagai et al, 1966 a), liver glycogen deposition and induction of liver tryptophan pyrrolase (Kumagai et al, 1966 b). Antiinflammatory or anti-exudative action of cortisone, however, was hardly affected by glycyrrhizin (Kumagai et al, 1964).…”

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confidence: 96%

Effects of Glycyrrhizin on Thymolytic and Immunosuppressive Action of Cortisone

et al. 1967

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SYNOPSISGlycyrrhizin has been clinically used as an anti-allergic agent, but its mechanism remains unknown. This study was undertaken to examine the effect of glycyrrhizin on thymolytic and immunosuppressive action of cortisone in normal rabbits and adrenalectomized rats. Immunization was performed by injection of bacterial a-amylase emulsified in Freund's incomplete adjuvant. Antibody titer of the serum was expressed as the enzyme-neutralizing activity. The circulating antibody could be detected in normal rabbits about 10 days after immunization and elevated lineally thereafter. The antibody titer was suppressed to one half and to one fourth of the control by administration of 15mg/Kg and 30mg/Kg of glycyrrhizin respectively. Glycyrrhizin had no effect on the antibody titer in the case of adrenalectomized rats, though the titer of the control in these rats was lower than that in normal rabbits. Cortisone treatment resulted in the decrease of the titer. By concomitant administration of glycyrrhizin with cortisone the antibody titer was much more decreased, thus showing an enhancing effect of glycyrrhizin on immunosuppressive action of cortisone. On the other hand, thymolytic action of cortisone was inhibited by concomitant administration of glycyrrhizin on the basis of thymus weight in rats. This effect of cortisone was blocked by glycyrrhizin. Glycyrrhizin by itself had no significant effect on thymus weight. The dissociation of the effect of glycyrrhizin on these cortisone actions suggests that one biological action of cortisone might come through some different mechanism from another. Mechanisms of the action of glycyrrhizin were discussed in relation to various biological actions of cortisone.

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