An Inhibitor of Herpesvirus Hominis in Extracts of Cultures of Burkitt's Lymphoma Cells

Rabson, Alan S.; Tyrrell, Sandra A.; Legallais, Frances Y.

doi:10.3181/00379727-137-35557

Cited by 13 publications

(4 citation statements)

References 4 publications

(4 reference statements)

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“…This substance may be interferon or another inhibitory product. Interestingly, extracts which can inhibit the replication of HSV have been obtained from malignant lymphoma cells (206) as well as hamster cells transformed by HSV-2 (64).…”

Section: Static State Hypothesismentioning

confidence: 99%

The latent herpes simplex virus.

Docherty¹,

Chopan²

1974

Bacteriological Reviews

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Section: Static State Hypothesismentioning

confidence: 99%

The latent herpes simplex virus.

Docherty¹,

Chopan²

1974

Bacteriological Reviews

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“…The relationships between EBV and other herpes viruses needs clarification. Rabson et al (1971), as well as Mizrahi et al (1972), observed an antagonism between EBV and other herpes viruses. The highest population of herpes simplex virus was attained in lymphoid cell lines that had no evidence of EBV particles (Fig.…”

Section: Epstein-barr Virusmentioning

confidence: 82%

Cultured human lymphocytes

Moore

1972

Journal of Surgical Oncology

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Success in establishing human lymphoid cell lines from patients with various genetic, infectious, and malignant disorders and from normal persons has facilitated many new avenues of research. Most lymphoid cell lines seem to remain stable for months and years and can be preserved in cell banks. The cells maintain many specific characteristics and produce at least 10 identifiable cell products. The continuing synthesis of immunoglobulins is of great interest to immunologists. It is possible to culture kilogram quantities of lymphoid cells for biochemical experiments. Large amounts of cells are useful for studies of lymphocyte‐tumor cell interaction and the possible treatment (lymphocytotherapy) of certain infections and malignancies.

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“…It would be of interest to investigate arginase activity of extracts prepared from cell cultures derived from neoplastic tissues, for an inhibitory proteinaceous substance active against herpes simplex virus (an arginine-requiring virus) recently was found in extracts of Burkitt's lymphoma cells (19). We have found that the canine LE was equally effective in interfering with growth of canine herpesvirus (13, unpublished results).…”

Section: Discussionmentioning

confidence: 99%

Identification of a Canine Adenovirus (Infectious Canine Hepatitis Virus) Inhibitor in Dog Liver Extracts as Arginase

Carmichael

1972

Infect Immun

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Extracts of canine liver inhibited growth of infectious canine hepatitis (ICH) virus, a canine adenovirus. Purified extracts from mammalian, but not avian, liver tissue contained the inhibitor, and evidence is presented that the inhibitory factor is the enzyme arginase (arginine ureohydrolase). This study further emphasized the need for arginine in adenovirus growth and may explain some of the difficulties in isolating small amounts of ICH virus from suspensions of liver. MATERIALS AND METHODSCells. Tube cultures of DK cells were prepared according to standard procedures. Inoculation medium was Earle saline solution that contained 5% heated 348

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An Inhibitor of Herpesvirus Hominis in Extracts of Cultures of Burkitt's Lymphoma Cells

Cited by 13 publications

References 4 publications

The latent herpes simplex virus.

The latent herpes simplex virus.

Cultured human lymphocytes

Identification of a Canine Adenovirus (Infectious Canine Hepatitis Virus) Inhibitor in Dog Liver Extracts as Arginase

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