An Ingestible Capsule for the Photodynamic Therapy of &lt;italic&gt;Helicobacter Pylori&lt;/italic&gt; Infection

Tortora, Giuseppe; Orsini, B.; Pecile, Patrizia; Menciassi, Arianna; Fusi, Franco; Romano, G.

doi:10.1109/tmech.2016.2536944

Cited by 31 publications

(28 citation statements)

References 25 publications

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“…Thus, alternative devices have been taken into account (Li et al, 2016;Romano et al, 2016). In the CapsuLight project, a swallowable pill containing LED sources has been proposed to perform intragastric H. pylori phototherapy in a minimally invasive way (Tortora et al, 2016). For this purpose it is crucial to determine the best illumination parameters able to activate the H. pylori photosensitizers, and to evaluate the LED emission module before proceeding to the integration in the final ingestible device, in order to maximize the bacteria photokilling during aPDT while taking care of battery power needs.…”

Section: Introductionmentioning

confidence: 99%

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

et al. 2020

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The rise of antibiotic resistance is the main cause for the failure of conventional antibiotic therapy of Helicobacter pylori infection, which is often associated with severe gastric diseases, including gastric cancer. In the last years, alternative non-pharmacological approaches have been considered in the treatment of H. pylori infection. Among these, antimicrobial PhotoDynamic Therapy (aPDT), a light-based treatment able to photoinactivate a wide range of bacteria, viruses, fungal and protozoan parasites, could represent a promising therapeutic strategy. In the case of H. pylori, aPDT can exploit photoactive endogenous porphyrins, such as protoporphyrin IX and coproporphyrin I and III, to induce photokilling, without any other exogenous photosensitizers. With the aim of developing an ingestible LED-based robotic pill for minimally invasive intragastric treatment of H. pylori infection, it is crucial to determine the best illumination parameters to activate the endogenous photosensitizers. In this study the photokilling effect on H. pylori has been evaluated by using a novel LED-based device, designed for testing the appropriate LEDs for the pill and suitable to perform in vitro irradiation experiments. Exposure to visible light induced bacterial photokilling most effectively at 405 nm and 460 nm. Sub-lethal light dose at 405 nm caused morphological changes on bacterial surface indicating the cell wall as one of the main targets of photodamage. For the first time endogenous photosensitizing molecules other than porphyrins, such as flavins, have been suggested to be involved in the 460 nm H. pylori photoinactivation.

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Section: Introductionmentioning

confidence: 99%

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

et al. 2020

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Section: Ingestible Robot For Surgical Interventionmentioning

confidence: 99%

“…Meanwhile, H. pylori contains natural photosensitizers and can be killed by excitation at specific wavelengths. Taking advantage of this opportunity, light emitting diode (LED) sources were integrated in an electronic capsule for the photodynamic therapy of H. pylori infections (see Figure e) . Preliminary results show that the device can kill the bacterium at a high efficiency of 96%.…”

Section: Ingestible Robot For Surgical Interventionmentioning

confidence: 99%

Robotics in the Gut

Min

Yang

et al. 2019

Advanced Therapeutics

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Since the advent of ingestible temperature sensors and capsule endoscopes, rapid advances in electronics, robotics, nanotechnology, and material sciences have opened the door for the development of novel medical ingestible robots. The untethered robots provide direct, non-invasive access to the entire gastrointestinal (GI) tract. Furthermore, the tissues, gases, and fluids of the gastrointestinal lumen contain a multitude of biomarkers indicative of gut diseases and health. Ingestible medical robots equipped with advanced imaging and sensing techniques can enable the diagnosis and monitoring of diseases, while providing a better pathophysiological understanding of gastrointestinal disorders. In addition, various robotic actuation mechanisms in the macro-and microscale can realize enhanced drug delivery and surgical interventions for the treatment of diseases. In this paper, an overview of recent advances in ingestible robots toward imaging, sensing, drug delivery, and surgical applications in the GI tract is provided. Key challenges and strategies for the development of novel ingestible robots and future directions of ingestible robots toward precision medicine are also discussed.

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“…The group of Tortora et al [37] investigate the efficiency of LEDs in specific wavelengths needed for the therapy of infection from Helicobacter pylori. Based on their measurements, two easy-to-swallow capsule devices have been developed.…”

Section: Blue and Red Light Capsule For Photodynamic Therapy Of Helicmentioning

confidence: 99%

“…An inflatable prototype capsule for haemostasis in the GI tract based on balloon tamponade effect hasBlue and Red Light Capsule for Photodynamic Therapy of Helicobacter Pylori[37] …”

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confidence: 99%

The future of capsule endoscopy in clinical practice: from diagnostic to therapeutic experimental prototype capsules

Vasilakakis

Koulaouzidis

Marlicz

et al. 2020

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Capsule endoscopy (CE) is indicated as a first-line clinical examination for the detection of small-bowel pathology, and there is an ever-growing drive for it to become a method for the screening of the entire gastrointestinal tract (GI). Although CE's main function is diagnosis, the research for therapeutic capabilities has intensified to make therapeutic capsule endoscopy (TCE) a target within reach. This manuscript presents the research evolution of CE and TCE through the last 5 years and describes notable problems, as well as clinical and technological challenges to overcome. This review also reports the state-of-the-art of capsule devices with a focus on CE research prototypes promising an enhanced diagnostic yield (DY) and treatment. Lastly, this article provides an overview of the research progress made in software for enhancing DY by increasing the accuracy of abnormality detection and lesion localisation. The future of capsule endoscopy-experimental devices for diagnosis and therapy Gastroenterology Review

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An Ingestible Capsule for the Photodynamic Therapy of <italic>Helicobacter Pylori</italic> Infection

Cited by 31 publications

References 25 publications

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device

Robotics in the Gut

The future of capsule endoscopy in clinical practice: from diagnostic to therapeutic experimental prototype capsules

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