An infrequent case of adult alveolar rhabdomyosarcoma with pancreatic metastases detected in F-18 FDG PET/CT

Natarajan, Aravintho; Puranik, Ameya; Purandare, Nilendu; Agrawal, Archi; Shah, Sneha; Rangarajan, Venkatesh

doi:10.4103/ijnm.ijnm_28_17

Cited by 6 publications

(7 citation statements)

References 11 publications

(14 reference statements)

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“…CT images allow radiologists not only to determine the extent of tumours but also to determine the absence or presence of bony destruction, calcification, haemorrhage and/or metastases 3 , However, in fact, during the course of routine radiology diagnosis, because RMS has the general radiological appearance of soft tissue tumors, it is difficult to distinguish it from other pelvic soft tissue malignancies. However, to our knowledge, there are currently few literature reports on the CT features of pelvic RMS 4 – 9 , and some reports have indicated that the CT findings of pelvic RMS lack specificity 10 – 12 . Therefore, it is imperative to investigate the CT features of pelvic RMS and establish an accurate diagnostic method for pelvic RMS in children.…”

Section: Introductionmentioning

confidence: 99%

Fisher discriminant model based on LASSO logistic regression for computed tomography imaging diagnosis of pelvic rhabdomyosarcoma in children

Tian

Zheng

et al. 2022

Sci Rep

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Computed tomography (CT) has been widely used for the diagnosis of pelvic rhabdomyosarcoma (RMS) in children. However, it is difficult to differentiate pelvic RMS from other pelvic malignancies. This study aimed to analyze and select CT features by using least absolute shrinkage and selection operator (LASSO) logistic regression and established a Fisher discriminant analysis (FDA) model for the quantitative diagnosis of pediatric pelvic RMS. A total of 121 pediatric patients who were diagnosed with pelvic neoplasms were included in this study. The patients were assigned to an RMS group (n = 36) and a non-RMS group (n = 85) according to the pathological results. LASSO logistic regression was used to select characteristic features, and an FDA model was constructed for quantitative diagnosis. Leave-one-out cross-validation and receiver operating characteristic (ROC) curve analysis were used to evaluate the diagnostic ability of the FDA model. Six characteristic variables were selected by LASSO logistic regression, all of which were CT morphological features. Using these CT features, the following diagnostic models were established: (RMS group) ; (Non-RMS group) , where , , … and are lower than normal muscle density (1 = yes; 0 = no), multinodular fusion (1 = yes; 0 = no), enhancement at surrounding blood vessels (1 = yes; 0 = no), heterogeneous progressive centripetal enhancement (1 = yes; 0 = no), ring enhancement (1 = yes; 0 = no), and hemorrhage (1 = yes; 0 = no), respectively. The calculated area under the ROC curve (AUC) of the model was 0.992 (0.982–1.000), with a sensitivity of 94.4%, a specificity of 96.5%, and an accuracy of 95.9%. The calculated sensitivity, specificity and accuracy values were consistent with those from cross-validation. An FDA model based on the CT morphological features of pelvic RMS was established and could provide an easy and efficient method for the diagnosis and differential diagnosis of pelvic RMS in children.

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Section: Introductionmentioning

confidence: 99%

Fisher discriminant model based on LASSO logistic regression for computed tomography imaging diagnosis of pelvic rhabdomyosarcoma in children

Tian

Zheng

et al. 2022

Sci Rep

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“…Several studies have shown that PET-CT improved the initial staging accuracy in adult RMS, specifically the detection of distant metastatic spread. 6,12,13 In our patient, pancreatic body metastasis was detected by PET-CT.…”

Section: Discussionmentioning

confidence: 57%

“…The pancreas is considered a rare metastatic site in patients with newly diagnosed RMS 6,7 . In a retrospective analysis, four (5.6%) of 77 patients with alveolar RMS had pancreatic metastases at initial presentation, including one adult case, whereas four patients presented with pancreatic metastases at the time of disease recurrence, including one adult case 7 .…”

Section: Discussionmentioning

confidence: 99%

“…5 Pancreatic metastases are rare in newly diagnosed patients. 6,7 The prognosis of adult RMS is dismal, especially in patients with distant metastasis. [3][4][5]8 Although standard therapies have not been established, surgery remains the mainstay of treatment, and complete resection should be attempted whenever possible.…”

Section: Introductionmentioning

confidence: 99%

“…The common sites of metastasis include the lungs, bone, omentum, and lymph nodes 5 . Pancreatic metastases are rare in newly diagnosed patients 6,7 …”

Section: Introductionmentioning

confidence: 99%

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