An influence of structural changes in ammonium cations on ecotoxicity of 2,2’-thiodiacetate mono and bis-salts

The need to change the approach to the safe use of herbicides by developing chiral and environmentally friendly formulations: a series of enantioselective (R)- and (S)-phenylethylammonium chloroacetates

“…In our current studies, we have combined haloacetic acid anions with optically active 1-phenylethylammonium cations to obtain new QASs which have not been investigated in the literature, so far, especially in the field of ecotoxicity and herbicidal activity. The concept to replace the heteroatom sequence in glyphosate by other heteroatoms has been applied by us in the QASs derived from 2,2′-thiodiacetic acid 14,15 and chlorophenoxy-and chlorophenylthioacetic acids. 16 We also investigated the eco( phyto)toxicity of achiral QASs composed of the diisopropylammonium cations and haloacetic acid anions 17 (Fig.…”

“…(R)-MCA, (S)-MCA, (R)-TCA, and (S)-TCA can be classified as ILs (a subgroup of QASs) due to their melting point of 100 °C and below 29 and two of them, (R)-DCA and (S)-DCA, as QASs. To Scheme 1 Chemical structures of herbicidal 1-hetero(O,N,S)-substituted ammonium acetates ( previous works [14][15][16][17] ) and their chiral analogs studied in this work.…”