An inflammatory memory and angiogenic self-assembling nanofiber hydrogel scaffold seeded with<i>Akkermansia muciniphila</i>to accelerate the healing of diabetic ischemic ulcers

Cheng, Panke; Yao, Liang; Chen, Xiaolong; Su, Xingxing; Su, Xuejiao; Huang, Qiang; Hou, Chun‐Li

doi:10.1039/c8ra01662c

Cited by 5 publications

(5 citation statements)

References 26 publications

(26 reference statements)

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“…In a study, an inflammatory memory peptide was extracted from absent in melanoma 2 to prepare a nanopeptide hydrogel ( Cheng et al, 2018 ). Subsequently, Akk ermansia muciniphila , a member of the intestinal microbiota with hypoglycaemic effect, was inoculated into the hydrogel.…”

Section: Application Of a Nanocomposite Hydrogel Delivery System To D...mentioning

confidence: 99%

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

Tong

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Diabetic ulcer is a serious complication of diabetes. Compared with that of healthy people, the skin of patients with a diabetic ulcer is more easily damaged and difficult to heal. Without early intervention, the disease will become increasingly serious, often leading to amputation or even death. Most current treatment methods cannot achieve a good wound healing effect. Numerous studies have shown that a nanocomposite hydrogel serves as an ideal drug delivery method to promote the healing of a diabetic ulcer because of its better drug loading capacity and stability. Nanocomposite hydrogels can be loaded with one or more drugs for application to chronic ulcer wounds to promote rapid wound healing. Therefore, this paper reviews the latest progress of delivery systems based on nanocomposite hydrogels in promoting diabetic ulcer healing. Through a review of the recent literature, we put forward the shortcomings and improvement strategies of nanocomposite hydrogels in the treatment of diabetic ulcers.

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Section: Application Of a Nanocomposite Hydrogel Delivery System To D...mentioning

confidence: 99%

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

Tong

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…Of 5844 screened studies, a total of 7 were included (online supplementary figure 1). [14][15][16][17][18][19][20]…”

Section: Study Selectionmentioning

confidence: 99%

“…Diabetes was present as a comorbidity in 322 wounds (Ischemia=161; Non-ischemia=161) during assessments performed at days 7 (n=144), 14 (n=136) and 21 (n=42). All included studies reported wound area at days 7 and 14, [14][15][16][17][18][19][20] whereas four studies reported wound area at day 21. 14 16-18 All time-points were eligible for meta-analysis.…”

Section: Effect Of Ischemia On Wound Healingmentioning

confidence: 99%

“…Five of the included studies investigated the effect of different interventions on wound healing and reported significant improvement in healing under both diabetic and non-diabetic conditions (table 3). These interventions included hyperbaric oxygen therapy, 18 angiogenic self-assembling nanofiber hydrogel scaffold seeded with Akkermansia muciniphila, 19 bone marrow aspirate and peripheral blood derived platelet-rich plasma, 16 embryonic artery CD133+ cells loaded with the Sirt1 agonist SRT1720 20 and knockout of Redox Enzyme p66Shc. 15 The interventions were reported to improve wound healing via multiple different mechanisms including increased collagen content, granulation tissue thickness, myofibroblast differentiation and capillary density in addition to increased expression levels of vascular endothelial growth factor (VEGF-A), interleukin-8 and basic fibroblast growth factor.…”

Section: Effect Of Interventions On Ischemic Woundsmentioning

confidence: 99%

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Animal models of ischemic limb ulcers: a systematic review and meta-analysis

Thanigaimani

Phie

Golledge

2020

BMJ Open Diab Res Care

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The aims of this systematic review were to assess the clinical relevance and quality of previously published animal models of ischemic ulceration and examine the available evidence for interventions improving ulcer healing in these models. Publicly available databases were searched for original studies investigating the effect of limb ischemia on wound healing in animal models. The quality of studies was assessed using two tools based on the Animal research: Reporting of In Vivo Experiments (ARRIVE) guidelines and the clinical relevance of the models. A total of 640 wounds (ischemic=314; non-ischemic=326) were assessed in 252 animals (92 mice, 140 rats, 20 rabbits) from 7 studies. Meta-analyses showed that wound healing was consistently delayed by ischemia at all time-points examined (day-7 standard median difference (SMD) 5.36, 95% CI 3.67 to 7.05; day-14 SMD 4.50, 95% CI 2.90 to 6.10 and day-21 SMD 2.53, 95% CI 1.25 to 3.80). No significant difference in wound healing was observed between 32 diabetic and 32 non-diabetic animals with ischemic wounds. Many studies lacked methods to reduce bias, such as outcome assessors blinded to group allocation and sample size calculations and clinically relevant model characteristics, such as use of older animals and a peripheral location of the wound. Five different interventions were reported to improve wound healing in these models. The impaired wound healing associated with limb ischemia can be modeled in a variety of different animals. Improvements in study design could increase clinical relevance, reduce bias and aid the discovery of translatable therapies.

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“…Intestinal microbes play a vital part in regulating host metabolism and surface inflammation. Several researches have shown that our eating lifestyles greatly impact the composition and function of the gut microbiota and may ultimately play a role in initiating or protecting against metabolic disorders [12,13].…”

Section: Role Of a Muciniphila In Obesity And Type 2 Diabetesmentioning

confidence: 99%

Efficiency of Akkermansia muciniphila in type 2 diabetes and obesity

2020

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Akkermansia muciniphila is an anaerobic species of gut microbiome that has been proposed as a new functional microbiota with probiotic properties. Recent research has shown the amazing abilities of probiotic bacteria, A. muciniphila, which resides in most people's intestines. These bacteria affect the body if it increases or decreases abdominal fat. The presence of A. muciniphila has opened new ways for the use of this plentiful intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is particularly effective in increasing mucosal thickness and enhancing bowel barrier function. As a result, host metabolic markers improve. The host functions that are disrupted in various diseases with a particular focus on metabolic disorders in animals and humans. A specific protein in the outer membrane of A. muciniphila called Amuc-110 could in the future be a strong candidate for drug production. As a result, we suggest that microbes and our microbiology or gut microbiome knowledge could be a new source for future treatments. The objectives of this review are to summarize the data available on the distribution of A. muciniphila gut in health and disease, to provide insights into the environment and its role in the creation of microbial networks at the mucosal interface, as well as to discuss recent research on its role in regulation.

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An inflammatory memory and angiogenic self-assembling nanofiber hydrogel scaffold seeded withAkkermansia muciniphilato accelerate the healing of diabetic ischemic ulcers

Cited by 5 publications

References 26 publications

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers

Animal models of ischemic limb ulcers: a systematic review and meta-analysis

Efficiency of Akkermansia muciniphila in type 2 diabetes and obesity

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