AN INFECTED HIP PROSTHESIS IN A DOG DIAGNOSED WITH A <sup>99m</sup>TC‐CIPROFLOXACIN (INFECTON) SCAN

Peremans, K.; Winter, F De; Janssens, L. A. A.; Dumont, Filip; Bree, Henri van; Dierckx, Rudi

doi:10.1111/j.1740-8261.2002.tb01666.x

Cited by 16 publications

(11 citation statements)

References 13 publications

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“…Controversial results were obtained using other animal models like rabbits, camelids, dogs or swines to evaluate the ability of 99m Tc-ciprofloxacin to localize the infectious site, in severe acute pancreatitis, prosthetic joint infections or other suspected infections [23–26]. …”

Section: Ciprofloxacinmentioning

confidence: 99%

“…a.— S. aureus Right thighMuscle––Carrageenan inflammationScintigraphyHigh sensitivity, low specificityAungurarat [19]1 hn. a.— S. aureus , P. aeruginosa Right thighMuscle1.751.8Turpentine oil, heat killed bacteria–Promising agentMirshojaei [22]1 h10 8 — S. aureus Right thighMuscle3.2–Sterile salineScintigraphyPromising agentZhang [20]4 h4 × 10 10 — Staphylobacterin Left thighMuscle4.301:03Turpentine oil–Sensitive radiopharmaceutical, simple preparationBhardwaj [14]24 h10 7 — S. aureus Right thighMuscle3.51.1Turpentine oilScintigraphyStable, safe preparation, specificSarda [23]–10 7 —MS S. aureus JointKnee––Sterile salineScintigraphyGood sensitivity but lack of specificity for knee prosthesisPeremans [26]––JointKnee–––ScintigraphyUseful for infected hip prosthesis diagnosisAlexander [25]––…”

Section: Summary Of Systematic Analysis Of the Literaturementioning

confidence: 99%

See 1 more Smart Citation

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Auletta

Galli

Lauri

et al. 2016

Clin Transl Imaging

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Bacterial infections are still one of the main causes of patient morbidity and mortality worldwide. Nowadays, many imaging techniques, like computed tomography or magnetic resonance imaging, are used to identify inflammatory processes, but, although they recognize anatomical modifications, they cannot easily distinguish bacterial infective foci from non bacterial infections. In nuclear medicine, many efforts have been made to develop specific radiopharmaceuticals to discriminate infection from sterile inflammation. Several compounds (antimicrobial peptides, leukocytes, cytokines, antibiotics…) have been radiolabelled and tested in vitro and in vivo, but none proved to be highly specific for bacteria. Indeed factors, including the number and strain of bacteria, the infection site, and the host condition may affect the specificity of tested radiopharmaceuticals. Ciprofloxacin has been proposed and intensively studied because of its easy radiolabelling method, broad spectrum, and low cost, but at the same time it presents some problems such as low stability or the risk of antibiotic resistance. Therefore, in the present review studies with ciprofloxacin and other radiolabelled antibiotics as possible substitutes of ciprofloxacin are reported. Among them we can distinguish different classes, such as cephalosporins, fluoroquinolones, inhibitors of nucleic acid synthesis, inhibitors of bacterial cell wall synthesis and inhibitors of protein synthesis; then also others, like siderophores or maltodextrin-based probes, have been discussed as bacterial infection imaging agents. A systematic analysis was performed to report the main characteristics and differences of each antibiotic to provide an overview about the state of the art of imaging infection with radiolabelled antibiotics.

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Section: Ciprofloxacinmentioning

confidence: 99%

Section: Summary Of Systematic Analysis Of the Literaturementioning

confidence: 99%

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Auletta

Galli

Lauri

et al. 2016

Clin Transl Imaging

View full text Add to dashboard Cite

show abstract

“…64 In companion animal species, Pseudomonas spp infections often involve the skin, urinary system, and ears, [65][66][67] along with SSIs and invasive device infections. 68,69 Biofilm formation by Pseudomonas spp can further complicate treatment. Identification of within hospital clusters of Pseudomonas infections should prompt investigation of potentially contaminated environmental, equipment (eg, endoscope), or consumable (eg, catheter preparation supplies) sources.…”

Section: Pseudomonas Sppmentioning

confidence: 99%

Hospital-Associated Infections in Small Animal Practice

Stull

Weese

2015

Veterinary Clinics of North America: Small Animal Practice

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Hospital-associated infections (HAIs) occur in veterinary hospitals of all types and sizes, and their frequency is likely to increase. Urinary tract infections, pneumonia, bloodstream infections, surgical site infections, and infectious diarrhea are the HAIs most frequently identified in veterinary medicine. A hospital infection control program, consisting of an infectious disease control officer, written protocols, and staff training, is critical to reducing HAIs and promoting patient, staff, and client health. Infection control protocols (plans) should include discussion of hand hygiene and use of personal protective equipment, cleaning and disinfection, patient management, with-in hospital surveillance, and antimicrobial stewardship.

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“…Animal study performed by Sarda et al [7] showed that infecton imaging has a good sensitivity in rabbits with infected knee prosthesis, but lack of specificity for the detection of S. aureus infection. Another study result indicated that infecton might be used in imaging a prosthetic hip infection in a dog [29]. Moreover, radiolabeled infecton has been shown to be useful for early diagnosis for osteomyelitis in rabbit by Southwood et al [30].…”

Section: Introductionmentioning

confidence: 97%

Evaluation of 99mTc-labeled antibiotics for infection detection

Yurt

2010

Ann Nucl Med

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One of the fields of research in nuclear medicine is the development of new radiopharmaceuticals for imaging infection and inflammation in humans. For this development, several antimicrobial peptides, antibiotics, antibiotic peptide and chemotactic peptides, etc., have been radiolabeled with different radionuclides (⁶⁷Ga, ⁹⁹(m)Tc, ¹¹¹In, ¹⁸F, ¹³¹I, etc.) and their imaging potentials studied. Actually, it is very important to distinguish between infection and inflammation. In this respect, radiolabeled antibiotics have advantages because many of the properties of the ideal infection-specific agent through antibiotics localizes in infection site. In this review, only ⁹⁹(m)Tc-labeled antibiotics are evaluated and discussed.

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AN INFECTED HIP PROSTHESIS IN A DOG DIAGNOSED WITH A ^99mTC‐CIPROFLOXACIN (INFECTON) SCAN

Cited by 16 publications

References 13 publications

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Hospital-Associated Infections in Small Animal Practice

Evaluation of 99mTc-labeled antibiotics for infection detection

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AN INFECTED HIP PROSTHESIS IN A DOG DIAGNOSED WITH A 99mTC‐CIPROFLOXACIN (INFECTON) SCAN

Cited by 16 publications

References 13 publications

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Imaging bacteria with radiolabelled quinolones, cephalosporins and siderophores for imaging infection: a systematic review

Hospital-Associated Infections in Small Animal Practice

Evaluation of 99mTc-labeled antibiotics for infection detection

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AN INFECTED HIP PROSTHESIS IN A DOG DIAGNOSED WITH A ^99mTC‐CIPROFLOXACIN (INFECTON) SCAN