An infant with chronic severe neutropenia

Bhat, Ramesh Y; Varma, Chaitanya; Bhatt, Sonia

doi:10.1136/bcr-2013-202908

Cited by 4 publications

(10 citation statements)

References 5 publications

(14 reference statements)

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“…Chronic idiopathic neutropenia has been reported to have a relatively mild prognosis [ 2 , 4 , 17 , 26 , 32 ]. However, neutropenia progress to severe forms such as hematologic malignancy in congenital neutropenia [ 1 , 6 , 33 , 34 , 35 , 36 ]. This study shows that severely low levels of neutrophil count during a long-term period do not necessarily lead to poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study

Lee

2020

Medicina

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Background and objectives: Severe chronic neutropenia (SCN) is a condition in which absolute neutrophil counts remain at a low level (under 500/µL) over months or years. Because of the rare onset of SCN, its epidemiology, prognosis, and clinical manifestations have not yet been fully understood. In particular, large-cohort studies in Asian countries are still insufficient. Therefore, in this study, national health insurance data was used to investigate the epidemiologic features and prognosis of SCN in South Korea. Materials and Methods: The data from the Health Insurance Review and Assessment database recorded between 1 January 2011 and 31 December 2015 were explored. SCN was defined based on the ICD-10 code, registry of benefit extension policy, and inclusion criteria of the study. After identifying patients with SCN, annual incidence and their co-morbidities were analyzed. Results: Among the initially identified patients with severe neutropenia (N = 2145), a total of 367 patients had SCN and were enrolled. The annual incidence rate of SCN ranged from 0.12 to 0.17 per 100,000 person-year (PY) during the study period. The highest incidence was observed in pediatric patients aged between 0 to 9 years (N = 156), followed by women in their fifties (N = 43). The total incidence rate was 0.17 in females and 0.12 in males (Relative risk (RR): 1.43, 95%, CI: 1.16–1.76). The most common accompanying condition was mild respiratory infection, but about 3.2% of patients progressed to hematologic malignancy after an average of 2.4 years. Conclusions: This nationwide population-based epidemiological study showed that incidence of SCN is higher in pediatrics and middle-aged women. As progression to hematologic malignancy was significantly higher in the age of in 45–49 year olds, careful follow-up is necessary in this group. However, since this study lacks the molecular information, these finding need to be interpreted with great caution.

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Section: Discussionmentioning

confidence: 99%

Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study

Lee

2020

Medicina

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“…4,5 The ANC can be highly variable in CBN typically ranging from 0 to 500 with fluctuations occurring irregularly. 3 While autoantibodies have been detected, they are not always present. 6,7 One study found them only in 21% of patients diagnosed with CBN.…”

Section: Discussionmentioning

confidence: 99%

“…15 Thankfully, this condition is largely self-limited in infancy with 95% achieving remission within 3 years. 3…”

Section: Discussionmentioning

confidence: 99%

“…In CBN of childhood, patients suffer from chronic neutropenia typically with normal or slightly decreased total lymphocyte count. 3 It seems to occur predominantly in infancy but as many as 10% of cases present outside this time frame. 4,5 The ANC can be highly variable in CBN typically ranging from 0 to 500 with fluctuations occurring irregularly.…”

Section: Discussionmentioning

confidence: 99%

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Febrile Neutropenia in an Infant

Unis

Carlson

Warrier

2019

Clin Pediatr (Phila)

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“…Treatment is generally supportive in nature. Despite the low ANC, the risk of infection is not high 38,39 …”

Section: Neutropenia With Normal Marrow Reservementioning

confidence: 99%

How I investigate neutropenia

Frater

2020

Int J Lab Hematology

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Neutropenia is a common laboratory finding in adults and children. Its underlying causes are extremely heterogeneous and include benign conditions, autoimmune disorders, infections, and malignancies. The clinical laboratory plays a central role in the diagnosis of these disorders, including data derived from hematology, microbiology, molecular biology/cytogenetics, and clinical chemistry. The purpose of this review is to (a) highlight the clinical, hematologic, and molecular genetic features of the major entities resulting in neutropenia and (b) outline an algorithm-based approach to permit the classification of neutropenias. K E Y W O R D S neutropenia, neutrophils

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An infant with chronic severe neutropenia

Cited by 4 publications

References 5 publications

Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study

Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study

Febrile Neutropenia in an Infant

How I investigate neutropenia

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