An inexpensive method of small photon field dosimetry with EBT3 radiochromic film

Mourya, Ankur; Aggarwal, Lalit Mohan; Mandal, Abhijit; Shahi, Uday Pratap; Ram, Chhape; Asthana, Anjana; Pradhan, Satyajit

doi:10.1007/s12553-018-0233-7

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…One of the greatest challenges in small animal dosimetry is the high spatial resolution required to measure small fields, especially when employing spatially fractionated microbeams, and this is where radiochromic films are second to none. The most widely used and characterized radiochromic film for kilovoltage dosimetry currently is GAFChromic EBT3 film (Ashland Advanced Materials, Bridgewater, NJ) [44][45][46][47][48][49][50][51][52][53][54][55]. EBT3 film has a nominal 28 μm thick active layer (Li-PCDA with dominant peaks at 633 and 595) [56] sandwiched between 125 μm thick matte layers of polyester-substrate, with an optimal dose range between 0.20 and 10 Gy and ≤ 25 μm measurement resolution [57,58].…”

Section: Radiochromic Filmsmentioning

confidence: 99%

A review of small animal dosimetry techniques: image-guided and spatially fractionated therapy

Johnstone,

Bazalova-Carter

2023

J. Phys.: Conf. Ser.

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Research in small animal radiotherapy is a crucial step in clinical translation of novel radiotherapy techniques, either delivered as stand-alone treatment or in combination with other treatments, such as chemotherapy and immunotherapy. In order to efficiently translate preclinical findings to the clinical setting, preclinical radiotherapy must replicate clinical therapy in terms of mode of delivery as well as dose delivery accuracy as closely as possible. In this review article, we focused on the description of dosimetry tools for radiotherapy of small animals delivered with kilovoltage x-ray beams on image-guided irradiators and in a spatially-fractionated manner by means of microbeam therapy. The specifics of dosimetry of kilovoltage x-ray beam deliveries with small, often sub-millimeter, beams are highlighted, and suitable dosimeters, phantoms, and dose measurement and calculation techniques are reviewed. Future directions for accurate real-time high spatial resolution dosimetry of small animal irradiations are also discussed.

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