An industrial perspective on metabolic responses of Penicillium chrysogenum to periodic dissolved oxygen feast‐famine cycles in a scale‐down system
Xueting Wang,
Qi Yang,
Cees Haringa
et al.
Abstract:While traveling through different zones in large‐scale bioreactors, microbes are most likely subjected to fluctuating dissolved oxygen (DO) conditions at the timescales of global circulation time. In this study, to mimic industrial‐scale spatial DO gradients, we present a scale‐down setup based on dynamic feast/famine regime (150 s) that leads to repetitive cycles with rapid changes in DO availability in glucose‐limited chemostat cultures of Penicillium chrysogenum. Such DO feast/famine regime induced a stable… Show more
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