An indoline-derived compound that markedly reduces mouse body weight

Tercel, Moana; Marnane, Rebecca; Ma, Tatnell; Rj, Stevenson; Halim, Angela; Gl, Lu; Duchesnes, Cécile E.; Truong, Mai Tuyet; Wa, Denny; Wr, Wilson; Kg, Mountjoy

doi:10.1038/ijo.2012.97

Cited by 2 publications

(2 citation statements)

References 13 publications

(18 reference statements)

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“… [5] In another study, an indoline‐derived compound was reported that could markedly reduce body weight and lower the blood sugar level in mouse models. [6] The indoline structure is widely found in natural compounds and has been widely reported as the focus of drug design in recent years. When it is structurally modified to join the indoline moiety in a fused or bonded form, new varieties with powerful pharmacological properties are usually produced.…”

Section: Introductionmentioning

confidence: 99%

“…High cholesterol in blood is one of the main causes of cardiovascular diseases, such as atherosclerosis, while the novel indoline derivatives as cholesterol ester protein (CETP) inhibitors was synthesized and showed the powerful effect of reducing cholesterol in blood [5] . In another study, an indoline‐derived compound was reported that could markedly reduce body weight and lower the blood sugar level in mouse models [6] . The indoline structure is widely found in natural compounds and has been widely reported as the focus of drug design in recent years.…”

Section: Introductionmentioning

confidence: 99%

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Development and Application of Indolines in Pharmaceuticals

Wei

Wang

et al. 2023

ChemistryOpen

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In recent years, the incidence of cancer is high around the world, and the resistance of bacteria is increasing. To cope with the potentially adverse side effects of cancer chemotherapy and surgery, researchers are turning to the construction of new drug scaffolds. The indoline structure exists in a huge number of natural products, but drugs with indoline have only been formally studied in recent years. With the deepening of research, drugs containing indoline have played important roles in more disease treatment aspects, such as anti‐tumor, anti‐bacterial, anti‐inflammatory and have been used as analgesics, to treat cardiovascular diseases and so on. The synthesis and pharmacological activity of indoline derivatives is summarized in this review in order to support the addition of the indoline component to the toolbox of medicinal chemists. This review focuses on the advantages of indoline compounds in development and synthesis of and for the use as anticancer drugs, antibacterial drugs, to treat cardiovascular diseases and as anti‐inflammatory and analgesic drugs. Indoline structures are commonly found in natural and synthetic compounds with medicinal value and are now beginning to be exploited as the basic backbone of various drugs. As research continues, dihydroindoles and their derivatives will play a greater role in the medical field.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Application of Indolines in Pharmaceuticals

Wei

Wang

et al. 2023

ChemistryOpen

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Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: A Review

Qiu

Zeng

et al. 2020

CMC

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Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. Despite the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of the novel and known compounds have at least partially been revealed. Therefore, the field does witness great progress year by year. In this review, we intend to provide a comprehensive and updated view on the known and novel compounds which possess anti-obesity effects and further classify them according to the molecular mechanisms of their actions in regulating the major anti-obesity pathways.

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An indoline-derived compound that markedly reduces mouse body weight

Cited by 2 publications

References 13 publications

Development and Application of Indolines in Pharmaceuticals

Development and Application of Indolines in Pharmaceuticals

Recent Development on Anti-Obesity Compounds and their Mechanisms of Action: A Review

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