An indirect microfluidic flow injection analysis (FIA) system allowing diffusion free pumping of liquids by using tetradecane as intermediary liquid

Rapp, Bastian E.; Carneiro, Leonardo Hoehl; Länge, Kerstin; Rapp, M.

doi:10.1039/b815690e

Cited by 25 publications

(16 citation statements)

References 11 publications

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“…This disposable component allows the connection of up to 8 SAW biosensor chips -which are simply clipped into corresponding cavities -as well as it provides a direct connection with the sample resulting in an integrated microfluidic system. Details of the complete set-up have been published earlier [5]. Parylene coating: All SAW devices used in the following experiments were first coated with 0.1 μm parylene C to obtain a chemically homogeneous surface.…”

Section: A Saw Device Instrumentation and Fluidic Systemmentioning

confidence: 99%

Surface Acoustic Wave (SAW) Biosensor Chip System - a Promising Alternative for Biomedical Applications

Gruhl¹,

Rapp²,

Rapp³

et al. 2009

IFMBE Proceedings

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Abstract-Surface acoustic wave (SAW) biosensors based on horizontally polarized surface shear waves enable labelfree, sensitive and cost-effective detection of biomolecules in real time. Binding reactions on the sensor surface are detected by determining changes in surface wave velocity caused mainly by mass loading in the sensing layer. Typically SAW devices are coated with biochemically sensitive layers including analyte-specific capture molecules or ligands. For the development of an array, single SAW devices first are embedded in polymer housings, however, the sensitive sensor area still remains accessible for surface modification. Advantages of those SAW biosensor chips are simple handling and low consumption of chemicals used in the coating process. An integrated microfluidic chip connects eight SAW biosensor chips to an array. An additional feature of the microfluidic chip is the direct connection between sample and biosensor chips allowing small sample volumes. This SAW biosensor chip array enables simultaneous analysis of multiple analytes in one sample. A potential application of such an array is the use in future point-of-care (POC) devices. First affinity experiments using this set-up will be shown.

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Section: A Saw Device Instrumentation and Fluidic Systemmentioning

confidence: 99%

Surface Acoustic Wave (SAW) Biosensor Chip System - a Promising Alternative for Biomedical Applications

Gruhl¹,

Rapp²,

Rapp³

et al. 2009

IFMBE Proceedings

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“…We have reported about the feasibility of using such an indirect microfluidic system in combination with external sensors before (Rapp et al 2009). However, this specific microfluidic system did not yet allow direct sensor integration as this required a significant redesign of the system.…”

Section: Introductionmentioning

confidence: 99%

“…We have previously suggested an alternative solution to solve this problem using a so called indirect microfluidic system (Rapp et al 2009). This type of systems makes use of a second intermediate liquid which is immiscible with the analyte (see Fig.…”

Section: Introductionmentioning

confidence: 99%

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Design and integration of a generic disposable array-compatible sensor housing into an integrated disposable indirect microfluidic flow injection analysis system

Rapp

Schickling

Prokop

et al. 2011

Biomed Microdevices

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We describe an integration strategy for arbitrary sensors intended to be used as biosensors in biomedical or bioanalytical applications. For such devices ease of handling (by a potential end user) as well as strict disposable usage are of importance. Firstly we describe a generic array compatible polymer sensor housing with an effective sample volume of 1.55 μl. This housing leaves the sensitive surface of the sensor accessible for the application of biosensing layers even after the embedding. In a second step we show how this sensor housing can be used in combination with a passive disposable microfluidic chip to set up arbitrary 8-fold sensor arrays and how such a system can be complemented with an indirect microfluidic flow injection analysis (FIA) system. This system is designed in a way that it strictly separates between disposable and reusable components- by introducing tetradecane as an intermediate liquid. This results in a sensor system compatible with the demands of most biomedical applications. Comparative measurements between a classical macroscopic FIA system and this integrated indirect microfluidic system are presented. We use a surface acoustic wave (SAW) sensor as an exemplary detector in this work.

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“…Currently commercially available valves are mostly based on solenoids (Bürkert 6650, Kendrion Tri-Tech, LEE LFV, Staiger VA 204-7, Takasago VODA) and larger than 10 × 10 × 10 mm 3 , leaving potential for further development. For high-density integration of microvalves, alternative concepts based on indirect actuation have been developed [43][44][45]. Two layers of microfluidic channels are built on top of each other and coupled either by an elastomeric intermediate membrane or two non-miscible fluids.…”

Section: Microfluidic Platformsmentioning

confidence: 99%

Modular Platforms for Optofluidic Systems

Brammer

Mappes

2014

Optofluidics, Microfluidics and Nanofluidics

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Optofluidics is increasingly gaining impact in a number of different fields of research, namely biology and medicine, environmental monitoring and green energy. However, the market for optofluidic products is still in the early development phase. In this manuscript, we discuss modular platforms as a potential concept to facilitate the transfer of optofluidic sensing systems to an industrial implementation. We present microfluidic and optical networks as a basis for the interconnection of optofluidic sensor modules. Finally, we show the potential for entire optofluidic networks.

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An indirect microfluidic flow injection analysis (FIA) system allowing diffusion free pumping of liquids by using tetradecane as intermediary liquid

Abstract: We suggest an indirect microfluidic flow injection analysis (FIA) system which uses tetradecane (C14H30) as intermediary liquid allowing the diffusion free handling of liquids in a fluidic system which is suitable for single use applications as required, e.g., biomedical applications.

Cited by 25 publications

References 11 publications

Surface Acoustic Wave (SAW) Biosensor Chip System - a Promising Alternative for Biomedical Applications

Surface Acoustic Wave (SAW) Biosensor Chip System - a Promising Alternative for Biomedical Applications

Design and integration of a generic disposable array-compatible sensor housing into an integrated disposable indirect microfluidic flow injection analysis system

Modular Platforms for Optofluidic Systems

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