An Indirect Method for Estimating Tissue Pressure with Special Reference to Tissue Pressure in Muscle during Exercise<sup>1</sup>

Kjellmer, Ingemar

doi:10.1111/j.1748-1716.1964.tb03948.x

Cited by 40 publications

(13 citation statements)

References 13 publications

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“…This implied that the effects of the so-called 'waterfall phenomenon' (e.g. Kjellmer, 1964) could be avoided and in addition, it produced some distension of the veins so that passive pressure dependent adjustments of the capacitance vessels were minimized (Oberg, 1967). With this cuff pressure, the transmural pressure of the veins was roughly brought back to the normal value existing in a region at heart level, and the recorded venous pressure in the two studied regions remained virtually constant during the elicitation of a capacitance response.…”

Section: A T E R I a L S A N D M E T H O D S Experiments In Manmentioning

confidence: 98%

Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral Circulation

1970

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A comparative quantitative study of the effects of dihydroergotamine (DHE)and noradrenaline (NA) on the precapillary and postcapillary resistance vessels, the precapillary 'sphincters', and the capacitance vessels was performed in a skeletal muscle and a skin region in healthy humans and in patients with orthostatic symptoms; further, the vascular effects of the drugs were analysed in muscle, skin, intestine and kidney in cats before and after sympathectomy.2. The two drugs evoked a similar pattern of response in the cutaneous vascular bed, i.e. they both constricted resistance and capacitance vessels, increased the ratio of pre-/post-capillary resistance, but did not significantly influence precapillary sphincters. The reactions were similar in skeletal muscle for NA and also for DHE, with the important exception that the latter drug usually elicited a moderate dilator response in the muscle resistance vessels.3. The average constrictor responses of the capacitance vessels were significantly larger for DHE than NA in skin and also in muscle despite the fact that DHE did not much affect the resistance vessels in muscle.4. The effects of DHE on the intestinal and renal vascular circuits in the cat were comparatively small. 5. Since the constrictor effect of DHE seems confined mainly to the capacitance vessels, the drug may have beneficial effects in circulatory disorders characterized by impaired venomotor regulation.A thorough description of the effects on the peripheral circulation of a vasoactive drug cannot be made unless quantitative information is available about the reactions evoked in the functionally differentiated consecutive sections of the vascular beds (see Mellander & Johansson, 1968). Drug induced changes of tone in the resistance vessels influence regional blood flow, and changes of activity in the precapillary 'sphincters' determine the number of patent capillaries and therefore, the size of the functional capillary surface area available for exchange.

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Section: A T E R I a L S A N D M E T H O D S Experiments In Manmentioning

confidence: 98%

Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral Circulation

1970

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“…Both hydrostatic vascular pressure and the interstitial pressure COP tend to move water from capillaries, while vascular COP and interstitial hydrostatic oppose this movement. In peri pheral capillaries, such as those of the skin and subcutaneous tissues, inter stitial COP and hydrostatic pressures have been reported varying from + 5 to -15 mmHg depending on the method employed to determine this value [5,15,20,46], If one assumes a slightly positive value, as found by W id erhielm [53], then the capillary leak of fluid is dependent upon intravascular hydrostatic pressure -COP differences.…”

Section: Discussionmentioning

confidence: 78%

Physiologic Changes Associated with Increasing Pulmonary Wedge Pressures in the Dog

Glauser¹,

Hoshiko²,

Watanabe³

et al. 1974

Respiration

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The effects of systematically increasing pulmonary wedge pressure (PWP) between baseline normal values and 30 mmHg on physiologic parameters was studied in ten mongrel dogs.After obtaining baseline normal values, the PWP was raised in stepwise increments of 5–7.5 mm Hg by inflating an intra-aortic balloon and infusing iso-oncotic fluids.The following decreased significantly at most levels of PWP measured: PaO₂, mmHg, supine (r=-0.708, p < 0.001); semi-upright (r=-0.681, p < 0.01); DLCO, ml/min/mmHg/kg (r=-0.543, p < 0.01). Circulation time (r=0.612, p < 0.01) and central blood volume (r = 0.471, p < 0.01) increased significantly at most levels of PWP observed. Upright chest X-ray changed from baseline at PWP of 19 mmHg

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“…Recruitment of non-perfused capillaries occurs in association with the hyperemia that accompanies exercise [317][318][319]321]. It is thought that terminal arterioles control the number of perfused capillaries, while larger arterioles and resistance arteries regulate vascular resistance and blood flow [47,105,145,199,257,439].…”

Section: 2 Diffusion Of Oxygenmentioning

confidence: 99%

Skeletal Muscle Circulation

Korthuis

2011

Colloquium Series on Integrated Systems Physiology: From Molecule to Function

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Physiology is a scientific discipline devoted to understanding the functions of the body. It addresses function at multiple levels, including molecular, cellular, organ, and system. An appreciation of the processes that occur at each level is necessary to understand function in health and the dysfunction associated with disease. Homeostasis and integration are fundamental principles of physiology that account for the relative constancy of organ processes and bodily function even in the face of substantial environmental changes. This constancy results from integrative, cooperative interactions of chemical and electrical signaling processes within and between cells, organs and systems. This eBook series on the broad field of physiology covers the major organ systems from an integrative perspective that addresses the molecular and cellular processes that contribute to homeostasis. Material on pathophysiology is also included throughout the eBooks. The state-of the-art treatises were produced by leading experts in the field of physiology. Each eBook includes stand-alone information and is intended to be of value to students, scientists, and clinicians in the biomedical sciences. Since physiological concepts are an ever-changing work-in-progress, each contributor will have the opportunity to make periodic updates of the covered material.Published titles (for future titles please see the website,

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An Indirect Method for Estimating Tissue Pressure with Special Reference to Tissue Pressure in Muscle during Exercise¹

Abstract: Kjellnier, I. An indirect method for estimating tissue pressure with speciul reference to tissue pressure in muscle duriti,? exercise. Acta physiol. scand. 1964. 62. 31-40. -Tissue pressure is one of the

Cited by 40 publications

References 13 publications

Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral Circulation

Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral Circulation

Physiologic Changes Associated with Increasing Pulmonary Wedge Pressures in the Dog

Skeletal Muscle Circulation

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An Indirect Method for Estimating Tissue Pressure with Special Reference to Tissue Pressure in Muscle during Exercise1

Abstract: Kjellnier, I. An indirect method for estimating tissue pressure with speciul reference to tissue pressure in muscle duriti,? exercise. Acta physiol. scand. 1964. 62. 31-40. -Tissue pressure is one of the

Cited by 40 publications

References 13 publications

Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral Circulation

Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral Circulation

Physiologic Changes Associated with Increasing Pulmonary Wedge Pressures in the Dog

Skeletal Muscle Circulation

Contact Info

Product

Resources

About

An Indirect Method for Estimating Tissue Pressure with Special Reference to Tissue Pressure in Muscle during Exercise¹