An indirect basal ganglia pathway in anuran amphibians?

Maier, Silke; Walkowiak, W.; Luksch, Harald; Endepols, Heike

doi:10.1016/j.jchemneu.2010.02.004

Cited by 17 publications

(11 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All the antibodies had been previously tested in Xenopus; many of them were used as territory markers in the forebrain, and the patterns of staining showed the same distribution as that observed in the present study (González and Smeets,1992; González et al,1993,2002a,b; Marín et al,1998a,b; Bachy and Rétaux, 2006; Moreno et al,2008a,b; Morona and González,2008; Maier et al,2010; Domínguez et al,2011; Morona et al,2011). Controls for the immunohistochemical experiments included: 1) Western blot (see the previous section and Fig.…”

Section: Methodssupporting

confidence: 72%

Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions

Domı́nguez

Morona

González

et al. 2013

J of Comparative Neurology

View full text Add to dashboard Cite

The patterns of expression of a set of conserved developmental regulatory transcription factors and neuronal markers were analyzed in the alar hypothalamus of Xenopus laevis throughout development. Combined immunohistochemical and in situ hybridization techniques were used for the identification of subdivisions and their boundaries. The alar hypothalamus was located rostral to the diencephalon in the secondary prosencephalon and represents the rostral continuation of the alar territories of the diencephalon and brainstem, according to the prosomeric model. It is composed of the supraoptoparaventricular (dorsal) and the suprachiasmatic (ventral) regions, and limits dorsally with the preoptic region, caudally with the prethalamic eminence and the prethalamus, and ventrally with the basal hypothalamus. The supraoptoparaventricular area is defined by the orthopedia (Otp) expression and is subdivided into rostral and caudal portions, on the basis of the Nkx2.2 expression only in the rostral portion. This region is the source of many neuroendocrine cells, primarily located in the rostral subdivision. The suprachiasmatic region is characterized by Dll4/Isl1 expression, and was also subdivided into rostral and caudal portions, based on the expression of Nkx2.1/Nkx2.2 and Lhx1/7 exclusively in the rostral portion. Both alar regions are mainly connected with subpallial areas strongly implicated in the limbic system and show robust intrahypothalamic connections. Caudally, both regions project to brainstem centers and spinal cord. All these data support that in terms of topology, molecular specification, and connectivity the subdivisions of the anuran alar hypothalamus possess many features shared with their counterparts in amniotes, likely controlling similar reflexes, responses, and behaviors.

show abstract

Section: Methodssupporting

confidence: 72%

Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions

Domı́nguez

Morona

González

et al. 2013

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…All the antibodies had been previously tested in Xenopus and Rana; many of them were used as territory markers in the forebrain, and the patterns of staining showed the same distribution as that observed in the present study (Marín et al, 1998a-c;González et al, 2002a,b;Bachy and Rétaux, 2006;González, 2003, 2007a,b;Moreno et al, 2008a;Morona and Gonzá-lez, 2008;Maier et al, 2010;Morona et al, 2011). Controls for the immunohistochemical experiments included: 1) Western blot (see the previous section and Fig.…”

Section: Controls and Specificity Of The Antibodiessupporting

confidence: 75%

“…Fragmentary information about the connections of the presently considered BST of anurans can be inferred from previous hodological studies concerning the pallium, basal ganglia, amygdaloid complex, preoptic area, thalamus, hypothalamus, midbrain, and brainstem (Neary and Wilczynski, 1977;Neary, 1984Neary, , 1988Neary, , 1990Neary, , 1995Hall and Feng, 1987;Wilczynski, 1991, 1994;Northcutt and Ronan, 1992;Marín et al, 1997a,b;Westhoff and Roth, 2002;Moreno and González, 2003Roth et al, 2003Roth et al, , 2004Endepols et al, 2004;Laberge and Roth, 2007;Maier et al, 2010). Roth and collaborators (2004) described for Bombina orientalis the connections of a region comparable to the BST after biocytin applications, but they discussed the results in terms of ventral pallidum/medial amygdala connections.…”

Section: Bst Connections In Anuransmentioning

confidence: 98%

Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

Moreno

Morona

López

et al. 2011

J of Comparative Neurology

View full text Add to dashboard Cite

Major common features have been reported for the organization of the basal telencephalon in amniotes, and most characteristics were thought to be acquired in the transition from anamniotes to amniotes. However, gene expression, neurochemical, and hodological data obtained for the basal ganglia and septal and amygdaloid complexes in amphibians (anamniotic tetrapods) have strengthened the idea of a conserved organization in tetrapods. A poorly characterized region in the forebrain of amniotes has been the bed nucleus of the stria terminalis (BST), but numerous recent investigations have characterized it as a member of the extended amygdala. Our study analyzes the main features of the BST in anuran amphibians to establish putative homologies with amniotes. Gene expression patterns during development identified the anuran BST as a subpallial, nonstriatal territory. The BST shows Nkx2.1 and Lhx7 expression and contains an Islet1-positive cell subpopulation derived from the lateral ganglionic eminence. Immunohistochemistry for diverse peptides and neurotransmitters revealed that the distinct chemoarchitecture of the BST is strongly conserved among tetrapods. In vitro tracing techniques with dextran amines revealed important connections between the BST and the central and medial amygdala, septal territories, medial pallium, preoptic area, lateral hypothalamus, thalamus, and prethalamus. The BST receives dopaminergic projections from the ventral tegmental area and is connected with the laterodorsal tegmental nucleus and the rostral raphe in the brainstem. All these data suggest that the anuran BST shares many features with its counterpart in amniotes and belongs to a basal continuum, likely controlling similar reflexes, reponses, and behaviors in tetrapods.

show abstract

“…The basal ganglia circuitry for motor output is well studied in birds as well, and known to be essentially similar to that of mammals (Reiner, 2002). Immunohistochemical and hodological studies suggest that amphibians also share the basic basal ganglia organization similar to amniotes (Marin et al, 1998b; Maier et al, 2010). Together with abundant TH terminals (González and Smeets, 1994; Marin et al, 1998a) and D 1A receptors (our unpublished data) in the amphibian striatum, it is likely that the role of DA in the basal ganglia motor control is conserved in tetrapods.…”

Section: Molecular Components Defining the Phenotype Of Da Neurons Anmentioning

confidence: 99%

The Evolution of Dopamine Systems in Chordates

Yamamoto¹,

Vernier²

2011

Front. Neuroanat.

194

212

View full text Add to dashboard Cite

Dopamine (DA) neurotransmission in the central nervous system (CNS) is found throughout chordates, and its emergence predates the divergence of chordates. Many of the molecular components of DA systems, such as biosynthetic enzymes, transporters, and receptors, are shared with those of other monoamine systems, suggesting the common origin of these systems. In the mammalian CNS, the DA neurotransmitter systems are diversified and serve for visual and olfactory perception, sensory–motor programming, motivation, memory, emotion, and endocrine regulations. Some of the functions are conserved among different vertebrate groups, while others are not, and this is reflected in the anatomical aspects of DA systems in the forebrain and midbrain. Recent findings concerning a second tyrosine hydroxylase gene (TH2) revealed new populations of DA-synthesizing cells, as evidenced in the periventricular hypothalamic zones of teleost fish. It is likely that the ancestor of vertebrates possessed TH2 DA-synthesizing cells, and the TH2 gene has been lost secondarily in placental mammals. All the vertebrates possess DA cells in the olfactory bulb, retina, and in the diencephalon. Midbrain DA cells are abundant in amniotes while absent in some groups, e.g., teleosts. Studies of protochordate DA cells suggest that the diencephalic DA cells were present before the divergence of the chordate lineage. In contrast, the midbrain cell populations have probably emerged in the vertebrate lineage following the development of the midbrain–hindbrain boundary. The functional flexibility of the DA systems, and the evolvability provided by duplication of the corresponding genes permitted a large diversification of these systems. These features were instrumental in the adaptation of brain functions to the very variable way of life of vertebrates.

show abstract

An indirect basal ganglia pathway in anuran amphibians?

Cited by 17 publications

References 84 publications

Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions

Characterization of the hypothalamus of Xenopus laevis during development. I. The alar regions

Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

The Evolution of Dopamine Systems in Chordates

Contact Info

Product

Resources

About