An index of spindle efficacy obtained by measuring electroneurographic activity and passive tension in the rat soleus muscle

Rosant, C.; Pérot, C.

doi:10.1016/j.jneumeth.2005.07.001

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…There is evidence that spindle afferent discharges are related to changes in the elastic properties of the tissues in which they are embedded 59 . Specifically, it has been reported that stiffer muscle-tendon elements ensure that the muscle spindles are more sensitive to imposed external forces 60 .…”

Section: Implications For Rehabilitationmentioning

confidence: 99%

Muscle-based perception: theory, research and implications for rehabilitation

Carello¹,

Pl²,

Kinsella-Shaw³

et al. 2008

Rev. bras. fisioter.

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Section: Implications For Rehabilitationmentioning

confidence: 99%

Muscle-based perception: theory, research and implications for rehabilitation

Carello¹,

Pl²,

Kinsella-Shaw³

et al. 2008

Rev. bras. fisioter.

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“…From a mechanical point of view, skeletal muscle can also be characterized by its resistance to passive stretch. From a functional point of view, muscle passive properties are important to take into account because (1) these characteristics contribute in part to the maximal joint range of motion, (2) part of the force developed by the contracting muscle will be devoted to the stretch of passive antagonist and (3) a relation between passive stiffness and spindle discharge has been shown 12. …”

Section: Introductionmentioning

confidence: 99%

Passive stiffness of rat skeletal muscle undernourished during fetal development

Toscano

Ferraz

Castro

et al. 2010

Clinics

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OBJECTIVES:The aim of the study was to investigate the effect of fetal undernutrition on the passive mechanical properties of skeletal muscle of weaned and young adult rats.INTRODUCTION:A poor nutrition supply during fetal development affects physiological functions of the fetus. From a mechanical point of view, skeletal muscle can be also characterized by its resistance to passive stretch.METHODS:Male Wistar rats were divided into two groups according to their mother's diet during pregnancy: a control group (mothers fed a 17% protein diet) and an isocaloric low‐protein group (mothers fed a 7.8% protein diet). At birth, all mothers received a standardized meal ad libitum. At the age of 25 and 90 days, the soleus muscle and extensor digitorum longus (EDL) muscles were removed in order to test the passive mechanical properties. A first mechanical test consisted of an incremental stepwise extension test using fast velocity stretching (500 mm/s) enabling us to measure, for each extension stepwise, the dynamic stress (σd) and the steady stress (σs). A second test consisted of a slow velocity stretch in order to calculate normalized stiffness and tangent modulus from the stress–strain relationship.RESULTS:The results for the mechanical properties showed an important increase in passive stiffness in both the soleus and EDL muscles in weaned rat. In contrast, no modification was observed in young adult rats.CONCLUSIONS:The increase in passive stiffness in skeletal muscle of weaned rat submitted to intrauterine undernutrition it is most likely due to changes in muscle passive stiffness.

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“…Similar to our results, both dynamic and static response of spindle afferents to ramp and hold stretch are reduced in aged rats (Miwa et al 1995). The change in muscle spindle afferent sensitivity due to aging has been linked to factors such as an increase in passive stiffness (Rosant and Pérot 2006) as a result of increased capsular collagen (Miwa et al 1995). Additionally, with increasing age, the mean number of intrafusal muscle fibers in the muscle decreases (Swash and Fox 1972).…”

Section: Chapter 3 Conclusion and Future Directionssupporting

confidence: 85%

Diet Induced Obesity Alters Muscle Spindle Afferent Function in Adult Mice

Elahi

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Individuals with obesity are more likely to fall and exhibit balance instability. The reason for this is likely multifactorial, but there is some evidence that sensory function is impaired during obesity. We tested the hypothesis that muscle proprioceptor function is compromised in a mouse model of diet induced obesity. We used an in vitro musclenerve preparation to record muscle spindle afferent responses to physiological stretch and sinusoidal vibration. We compared the responses of mice on a control diet (10% kcal fat) with those eating a high fat diet (60% kcal fat) alone or in combination with either aspirin (120mg/kg/day in drinking water) or rosiglitazone (0.01% in chow) for 10 weeks. Following high fat diet feeding, adult mice exhibited decreased muscle spindle afferent responses to stretch and lower dynamic sensitivity. Treatment with aspirin or rosiglitazone did not completely rescue muscle spindle afferent responsiveness. Due to the importance of muscle spindle afferents to proprioception and motor control, decreased muscle spindle afferent responsiveness may contribute to balance instability during obesity. Future studies should test this hypothesis in the human population. v ACKNOWLEDGMENTS First, I would like to thank members of the Wilkinson lab who assisted with running experiments and analyzing data. I would like to thank Shreejit Padmanabhan for analyzing muscle tension data, and Adam Abtahie and Adam Cai for assisting with vibration data analysis and crosschecking of data analysis. Second, I would like to thank Larry Young and Nelia Medeiros for providing essential animal training and continuous assistance with animal work. Third, I would like to thank my thesis committee members Dr. Michael Sneary and Dr. Rachael French for providing valuable criticisms. Finally, I would like to thank my amazing mentor Dr. Katherine Wilkinson for believing in me and giving me the opportunity to conduct research in her laboratory. Her encouragement and guidance helped me all throughout my research, writing of the thesis, and helped me become a better scientist. vi

show abstract

An index of spindle efficacy obtained by measuring electroneurographic activity and passive tension in the rat soleus muscle

Cited by 8 publications

References 29 publications

Muscle-based perception: theory, research and implications for rehabilitation

Muscle-based perception: theory, research and implications for rehabilitation

Passive stiffness of rat skeletal muscle undernourished during fetal development

Diet Induced Obesity Alters Muscle Spindle Afferent Function in Adult Mice

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