An increase in Wharton's jelly membrane osteocompatibility by a genipin-cross-link

Scomazzon, Loïc; Ledouble, Charlotte; Dubus, Marie; Braux, Julien; Guillaume, Christine; Bouland, Nicole; Baldit, Adrien; Boulmedais, Fouzia; Gribova, Varvara; Mauprivez, Cédric; Kerdjoudj, Halima

doi:10.1016/j.ijbiomac.2023.127562

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Advantages Of Hydrogel-exosome Systems For Tissue Engineering1

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2024

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“…Genipin, a natural compound extracted from the fruits of plants in the Gardenia genus, reacts with amino-containing biomacromolecules like gelatin and polysaccharides to create crosslinks through the formation of covalent bonds. Its in vivo toxicity is much lower than that of traditional chemical crosslinkers such as glutaraldehyde [ 177 ]. Platelet-rich plasma-derived exosomes (PRP-Exos) can be encapsulated in hydrogels through covalent crosslinking with genipin.…”

Section: Advantages Of Hydrogel-exosome Systems For Tissue Engineeringmentioning

confidence: 99%