An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women

Mutlu-Türkoglu, Ü.; Öztezcan, Serdar; Telci, Ayşegül; Orhan, Yusuf; Aykaç‐Toker, Gülçin; Sıvas, Ahmet; Uysal, Müjdat

doi:10.1007/s102380300002

Cited by 59 publications

(39 citation statements)

References 29 publications

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“…15 It is also shown that obesity is associated with increases in endogenous lipid peroxides and oxidation of low-density lipoproteins. 16 In another study it was demonstrated that lipoprotein oxidizability is enhanced in obese young women, uncomplicated by hypertension, hypercholesterolaemia, diabetes or coronary heart disease. 17 In our study we also found high MDA levels in obese subjects than in nonobese ones.…”

Section: Discussionmentioning

confidence: 99%

Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels

Yeşilbursa

Serdar

et al. 2004

Int J Obes

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OBJECTIVE: Obesity is a well-known risk factor of atherosclerosis. Recent studies showed that obesity is associated with enhanced lipid peroxidation. The aim of this study is to investigate the effect of weight reduction with orlistat treatment on lipid peroxidation levels. We assessed lipid peroxidation by measuring the concentration of plasma malondialdehyde (MDA). DESIGN: A randomized, controlled, open-label 6-month study. SUBJECTS: In total, 36 obese (body mass index (BMI) 430 kg/m 2 ) and 11 healthy age-matched control subjects were enrolled in the study. MEASUREMENTS: Fasting glucose, triglyceride, total cholesterol, HDL cholesterol and LDL cholesterol and MDA levels were measured in both groups. Obese subjects received orlistat, 120 mg three times daily together with hypocaloric diet. After 6 months of treatment laboratory tests were repeated. RESULTS: MDA levels were significantly higher in obese patients than the control group (Po0.0001). After 6 months of treatment in obese subjects, the mean weight of the patients decreased by 6.8 kg, the BMI by 3.2 kg/m 2 . Plasma MDA levels were significantly reduced by weight loss from 270.77 to 0.8970.41 nmol/ml (Po0.001). BMI correlated with MDA levels at baseline (r ¼ 0.6, Po0.0001). Changes in BMI was positively associated with plasma MDA level reduction (r ¼ 0.36, Po0.05). CONCLUSION: These results indicate that obesity is associated with increases in endogenous lipid peroxides. Our data show that the indicator of lipid peroxidationFMDAFfalls markedly in association with weight loss with orlistat. The demonstration of decreased free radical generation has important implications for oxidative mechanism underlying obesity-associated disorders.

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Section: Discussionmentioning

confidence: 99%

Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels

Yeşilbursa

Serdar

et al. 2004

Int J Obes

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“…Intra-abdominal or visceral adiposity plays a fundamental role in the stimulation of hyperglycemia, dyslipidemia and hypertension, collectively termed metabolic syndrome, which is one of the most significant risk factors of cardiovascular diseases (Ford, 2005). Previously, a direct relation was found between general obesity and markers of oxidative stress (Mutlu-Turkoglu et al 2003). In humans the susceptibility of lipids to oxidative modification is an independent risk factor of coronary heart disease (Holvoet et al 2001).…”

Section: Obesity and Atherosclerosis: The Role Of Adipokines In Athermentioning

confidence: 99%

Alteration of PON1 Activity in Adult and Childhood Obesity and Its Relation to Adipokine Levels

Serés

Bajnok

Harangi

et al. 2009

Advances in Experimental Medicine and Biology

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Obesity as a pathogenic disorder is a predisposing factor for cardiovascular diseases and shows an increasing incidence in the industrialized countries. Adipokines such as leptin, adiponectin and resistin have a great impact on the development of atherosclerosis in obesity. Elevated levels of leptin have been found to be atherogenic whereas decreased levels of adiponectin have been proved to be anti-atherogenic in recent studies. The exact role of resistin in the process of atherosclerosis has so far remained uncertain and controversial. In our recent work, we studied the alteration in human paraoxonase-1 (PON1) activity and adipokine levels; furthermore, we also aimed at identifying the potential correlation between these parameters in this metabolic disorder. We investigated the abovementioned parameters both in adults and in children, with regard to the emerging role of childhood obesity and to get a clearer view of these factors during a whole lifetime. Investigating the adult population with a broad range of body mass index (BMI) we found significantly increased leptin and significantly decreased adiponectin and resistin levels and PON1 activity in the obese group compared to the lean controls. Adiponectin and resistin levels showed significantly positive correlation, while leptin and BMI showed significantly negative correlation with PON1 activity.Our findings were similar in childhood obesity: leptin showed significantly negative correlation, while adiponectin showed significantly positive correlation with PON1 activity. We found gender differences in the univariate correlations of leptin and adiponectin levels with PON1 activity in the adult population. In multiple regression analysis, adiponectin proved to be an independent factor of PON1 activity both in childhood and adult obesity, furthermore thiobarbituric acid-reactive substances (TBARS) also proved to be an independent predictor of the enzyme in adults, reflecting the important role of oxidative stress in obesity. Investigating PON 192 Q/R polymorphism by phenotypic distribution (A/B isoenzyme) in obese children, we found a significant correlation of PON1 arylesterase activity with leptin and adiponectin levels, and of body fat percentage with PON1 192 B isoenzyme.According to our studies, these metabolic changes in obesity predispose to the early development of atherosclerosis throughout our whole lifetime. Decreased activity of PON1 and alterations in adipokine levels in childhood obesity could contribute to an early commencement of this process, detected only later in adulthood by increased cardiovascular morbidity and mortality. Changed levels of leptin, adiponectin, resistin and PON1 activity at all ages, just like 192 Q/R polymorphism determined by phenotypic distribution, may be useful markers beside the general risk factors.Keywords (separated by '-') Adipokines -Leptin -Adiponectin -Resistin -Obesity -Paraoxonase-1 -Childhood Abstract Obesity as a pathogenic disorder is a predisposing factor for cardiovascular diseases and shows a...

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“…In this sense, in obese patients (Vincent & Taylor 2006) and in overweight animal models (Furukawa et al 2004, an elevated oxidative stress has been documented. Furthermore, depletion of the antioxidant defenses has also been described in obesity (Mutlu-Turkoglu et al 2003). This oxidative stress unbalanced status is related to chronic inflammation and hyperleptinemia (Vincent & Taylor 2006).…”

Section: Introductionmentioning

confidence: 99%

Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes

García-Díaz

Campión²,

Milagro³

et al. 2010

Journal of Molecular Endocrinology

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Antioxidant-based treatments are emerging as an interesting approach to possibly counteract obesity fat accumulation complications, since this is accompanied by an increased systemic oxidative stress. The aim of this study was to analyze specific metabolic effects of vitamin C (VC) on epididymal primary rat adipocytes. Cells were isolated and incubated for 72 h in culture medium, in the absence or presence of 1 . 6 nM insulin, within a range of VC concentrations (5-1000 mM).Glucose-and lipid-related variables as well as the secretion/expression patterns of several obesity-related genes were assessed. It was observed that VC dose dependently inhibited glucose uptake and lactate production, and also reduced glycerol release in both control and insulin-treated cells. Also, VC caused a dramatic concentration-dependent fall in leptin secretion especially in insulin-stimulated cells. In addition, VC (200 mM) induced Cdkn1a and Casp8, partially inhibited Irs3, and together with insulin drastically reduced Gpdh (listed as Gpd1 in the MGI database) gene expressions. Finally, VC and insulin down-regulatory effects were observed on extracellular and intracellular reactive oxygen species production respectively. In summary, this experimental assay describes a specific effect of VC in isolated rat adipocytes on glucose and fat metabolism, and on the secretion/expression of important obesity-related proteins.

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An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women

Cited by 59 publications

References 29 publications

Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels

Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels

Alteration of PON1 Activity in Adult and Childhood Obesity and Its Relation to Adipokine Levels

Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes

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